JAHA:高甘油三酯血症与低风险人群全因死亡和动脉粥样硬化性心血管事件的关联

2020-09-21 MedSci原创 MedSci原创

在大量低中度心血管风险患者中,TG中至重度升高与全因死亡和ASCVD事件风险显著增加有关。

在中低风险人群中,血浆高水平甘油三酸酯(TG)与全因死亡率和动脉粥样硬化性血管疾病(ASCVD)事件之间存在关联的证据十分有限。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究旨在明确高水平TG是否会影响人群队列的全因死亡和ASCVD事件风险。

研究人员使用了3个意大利地方卫生部门的管理数据库进行了回顾性纵向队列分析。所有的受试者在2010年1月1日至2015年12月31日期间至少进行一次TG测量,并随访至2016年12月。结局指标包括ASCVD事件和全因死亡。研究人员将TG水平正常(<150 mg/dL)的受试者与TG高水平(150–500 mg/dL)和TG极高水平(>500 mg/dL)的受试者进行比较。该研究共分析了158042名受试者(TG正常的142289人,高TG的15558人和TG极高的受试者195人)。

在整个队列中,ASCVD的总发生率和全因死亡率分别为每1000人每年7.2人和17.1人。在对潜在混杂因素进行多变量调整后,与正常TG受试者相比,TG高和极高的受试者全因死亡(风险比[HR]=1.49 [95%置信区间(CI)为1.36–1.63],P<0.001和HR=3.08 [95%CI为1.46–6.50],P<0.01)和ASCVD事件(HR=1.61 [95%CI为1.43-1.82],P<0.001和HR=2.30 [95%CI为1.02-5.18],P<0.05)风险显著增加。

由此可见,在大量低中度心血管风险患者中,TG中至重度升高与全因死亡和ASCVD事件风险显著增加有关。

原始出处:

Marcello Arca.et al.Association of Hypertriglyceridemia with All‐Cause Mortality and Atherosclerotic Cardiovascular Events in a Low‐Risk Italian Population: The TG‐REAL Retrospective Cohort Analysis.J AM HEART ASSOC.2020.https://www.ahajournals.org/doi/full/10.1161/JAHA.119.015801

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  5. 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GetPortalCommentsPageByObjectIdResponse(id=887209, encodeId=f33388e209b3, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Sep 21 21:53:03 CST 2020, time=2020-09-21, status=1, ipAttribution=)]
    2020-09-24 Lexi

    在大量低中度心血管风险患者中,TG中至重度升高与全因死亡和ASCVD事件风险显著增加有关。

    0

  6. 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    2020-09-23 zhaohui6731
  7. 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  8. 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  9. 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    2020-09-22 ms1000000223698072

    漂亮,队列这么多人不容易啊

    0

  10. 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GetPortalCommentsPageByObjectIdResponse(id=887209, encodeId=f33388e209b3, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Sep 21 21:53:03 CST 2020, time=2020-09-21, status=1, ipAttribution=)]
    2020-09-21 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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