Clin Gastroenterology H: 5-HT-4受体激动剂米沙必利治疗肠易激综合征患者的疗效和安全性分析

2021-02-27 MedSci原创 MedSci原创

肠易激综合症(IBS)是指功能性胃肠道相关的反复或持续出现的腹痛和排便习惯异常,IBS很常见,全世界的患病率是8.8%。IBS患者目前主要分为4个类别。

      肠易激综合症(IBS)是指功能性胃肠道相关的反复或持续出现的腹痛和排便习惯异常,IBS很常见,全世界的患病率是8.8%。IBS患者目前主要分为4个类别;患有便秘的IBS(IBS-C),腹泻为主的IBS,IBS混合排便习惯改变和未分类的IBS。5-羟基色胺4(5-HT4)受体激动剂-米沙必利作为一种新型的激动剂,对5-HT4受体具有很高的选择性,是治疗便秘的潜在靶点。因此,本项研究旨在探究米沙必利在治疗肠易激综合征患者中的疗效和安全性。

 

 

      研究人员纳入了从2012年12月至2013年8月间在日本33个医疗中心的就诊的171例由罗马III定义的IBS-C的患者。患者被随机分配至接受米沙必利治疗的组(1、4、12、40毫克)或安慰剂治疗,持续4周。主要观察结果是便秘改善情况,评估方法主要为进行每周完全自发排便(CSBM),腹部症状和IBS-C症状的评分。为了评估安全性,记录了不良事件(AE)的发生率。

 

 

      研究结果显示在第4周时,所有米沙必利组的CSBMs每周频率相对于基线的改善情况大于安慰剂组(P = .040),并且所有治疗组的IBS总体严重性指数评均有明显改善,尤其是在12 mg和40 mg组中改善情况最为突出。在米沙必利和安慰剂组中,出现治疗性AE的患者比例分别为55.0%和60.0%。最常见的突发治疗性AE是腹泻,但是两组患者并不存在统计学差异。

 

 

      本项研究通过对日本群众的前瞻性研究发现,米沙必利可以增加IBS-C患者的粪便频率,减少了腹部,并改善了整体IBS-C症状,并且耐受性良好。

 

 

 

原始出处:

Shin Fukudo. Et al. Efficacy and Safety of 5-HT4 Receptor Agonist Minesapride for Irritable Bowel Syndrome with Constipation in a Randomized Controlled Trial. Clinical Gastroenterology and Hepatology.2021.

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    2021-12-17 许安
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    2021-03-01 科研科研科研

    受体激动剂可治疗肠易激综合征患者

    0

  6. 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  9. 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CST 2021, time=2021-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1627851, encodeId=295c162e85141, content=<a href='/topic/show?id=ab4f66e8913' target=_blank style='color:#2F92EE;'>#激动剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66789, encryptionId=ab4f66e8913, topicName=激动剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=95bc21134754, createdName=medscijoin, createdTime=Mon Mar 01 12:33:43 CST 2021, time=2021-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=944323, encodeId=1edf9443235f, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Mon Mar 01 06:41:37 CST 2021, time=2021-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032822, encodeId=c1eb10328220a, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Sun Feb 28 00:33:43 CST 2021, time=2021-02-28, status=1, ipAttribution=)]
    2021-03-01 易水河

    学习学习

    0

  10. 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    2021-02-28 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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Am J Gastroenterol:依鲁沙多林可有效且安全的治疗罗哌酰胺治疗后效果不佳的肠易激综合征患者的腹泻症状

肠易激综合征伴腹泻(IBS-D)是一种功能性胃肠道疾病,患者往往在缓解症状的基础上采取干预措施,但其有效治疗方案仍然有限。近日,发表于Am J Gastroenterol的一项随机对照研究结果证实依鲁

Clin Gastroenterology H:“无用功”还是“没办法”——肠易激综合征的患者愿意为症状缓解承担大量用药风险

肠易激综合征(IBS)多数是由于反复的植物神经功能失调导致,由于长时间的休息不好、压力比较大导致的失眠、多虑、焦虑、烦躁、记忆力减退以及肠胃消化功能不良引起的。

Gastroenterology:粪菌群移植可减轻以肠腹胀为主的肠易激综合征患者的症状

肠易激综合症(IBS)是与肠功能异常有关的功能性胃肠疾病。有报道,粪便微生物菌群移植(FMT)在治疗以腹胀为症状的肠易激患者中有希望,因此,本项研究旨在研究了该治疗的疗效。

Clin Gastroenterology H:耳神经刺激可以改善患有肠易激综合征的青少年临床症状

耳神经刺激疗法,是一种非侵入性的将经皮电神经场刺激(PENFS)传递至外耳的神经刺激疗法,对患有功能性腹痛性疾病的小儿患者有效。

Nature:吃完东西肚子疼?可能是肠胃局部过敏了……

肠易激综合征(IBS)主要表现为腹痛及肠道活动规律改变,其标志性症状是异常疼痛信号或内脏过敏 (VHS)。据报道,全世界有多达20%的人在饭后出现胃肠道症状。

J Clin Invest:富含梭菌的微生物群会促进肠易激综合征患者粪便胆汁酸的过度排泄

粪便胆汁酸(BA)过多被认为是腹泻为主的肠易激综合征(IBS-D)的机制之一。然而,导致BA排泄过多的因素尚未明了。鉴于肠道微生物群在BA代谢中的重要性,我们推测肠道菌群失调可能导致IBS-D中BA排