JAHA:更年期血管舒缩症状与心血管疾病事件风险的关系

2021-01-21 MedSci原创 MedSci原创

VMS与随后发生CVD事件的风险增加相关。VMS可能是女性新的特异性CVD危险因素。

女性的血管疾病(CVD)具有独特的特征,其与生殖之间的关联尚未完全明确。血管舒缩症状(VMS)是更年期的典型症状,且与CVD危险因素和亚临床CVD有关。将VMS与CVD事件联系起来的证据十分有限。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员评估了频发和/或持续性VMS是否与致命和非致命性CVD事件的风险增加有关。该研究共纳入了3083名女性(基线时年龄为42至52岁),她们在22年内接受了16次面对面的随访。受试者评估纳入了调查VMS频率(0、1-5或≥6天/2周)、身体指标、静脉切开术和报告的CVD事件(心肌梗塞、卒中、心力衰竭和血运重建)的问卷。通过医疗记录裁定事件的子集,并获得受试者的死亡证明。在针对人口统计学、药物使用和CVD危险因素调整的Cox比例风险模型中,研究人员对基线VMS或随访期间持续性VMS与非致命性和致命性CVD事件之间的关系进行了评估。

随访期间,受试者经历了231次CVD事件。基线时频发VMS的女性随后发生CVD事件的风险较高(相对于无VMS;≥6天:风险比[HR] [95%CI]为1.51 [1.05-2.17],P=0.03;1-5天: HR [95%CI]为1.02 [0.75–1.39],P=0.89)。频发VMS且持续存在的女性CVD事件风险也增加(HR [95%CI]为1.77 [1.33-2.35],P<0.0001)。

由此可见,VMS与随后发生CVD事件的风险增加相关。VMS可能是女性新的特异性CVD危险因素

原始出处:

Rebecca C. Thurston.et al.Menopausal Vasomotor Symptoms and Risk of Incident Cardiovascular Disease Events in SWAN.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.017416

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    2021-04-29 carrotlyl

    感谢分享

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2037424, encodeId=72a1203e424dd, content=<a href='/topic/show?id=e9e289e771c' target=_blank style='color:#2F92EE;'>#血管舒缩症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89777, encryptionId=e9e289e771c, topicName=血管舒缩症状)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d81c2500028, createdName=12498561m32(暂无昵称), createdTime=Fri Jul 23 15:44:25 CST 2021, time=2021-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1820443, encodeId=e9f1182044319, content=<a href='/topic/show?id=c87f10089032' target=_blank style='color:#2F92EE;'>#风险的关系#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100890, encryptionId=c87f10089032, topicName=风险的关系)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Fri Aug 27 23:44:25 CST 2021, time=2021-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=961454, encodeId=a3a19614541c, content=感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210127/50a003c4097845e182c08afd64d8a509/bd766dfebe9c40e0bca2dae964601bdc.jpg, createdBy=22de5454917, createdName=carrotlyl, createdTime=Thu Apr 29 10:01:48 CST 2021, time=2021-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920386, encodeId=973f92038676, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRvvXNvY0kOJqn4liar3Q6V6yPuEIawCVUyP3jVADh5icIz0ibrsxia6fKAqKsDr33jPWrjqM3D7wcRNu/0, createdBy=5a881701729, createdName=小树熊, createdTime=Wed Jan 27 19:39:31 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268400, encodeId=50661268400fc, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sat Jan 23 13:44:25 CST 2021, time=2021-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498814, encodeId=9c3614988146a, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sat Jan 23 13:44:25 CST 2021, time=2021-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918850, encodeId=4f9d9188503b, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Thu Jan 21 23:19:03 CST 2021, time=2021-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918849, encodeId=2b54918849e1, content=女性的心血管疾病(CVD)具有独特的特征,其与生殖之间的关联尚未完全明确。, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Thu Jan 21 22:52:21 CST 2021, time=2021-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918846, encodeId=df919188461f, content=已学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af965454834, createdName=ms7000001733098528, createdTime=Thu Jan 21 22:50:01 CST 2021, time=2021-01-21, status=1, ipAttribution=)]
    2021-01-27 小树熊

    学习了,谢谢

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2037424, encodeId=72a1203e424dd, content=<a href='/topic/show?id=e9e289e771c' target=_blank style='color:#2F92EE;'>#血管舒缩症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89777, encryptionId=e9e289e771c, topicName=血管舒缩症状)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d81c2500028, createdName=12498561m32(暂无昵称), createdTime=Fri Jul 23 15:44:25 CST 2021, time=2021-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1820443, encodeId=e9f1182044319, content=<a href='/topic/show?id=c87f10089032' target=_blank style='color:#2F92EE;'>#风险的关系#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100890, encryptionId=c87f10089032, topicName=风险的关系)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Fri Aug 27 23:44:25 CST 2021, time=2021-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=961454, encodeId=a3a19614541c, content=感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210127/50a003c4097845e182c08afd64d8a509/bd766dfebe9c40e0bca2dae964601bdc.jpg, createdBy=22de5454917, createdName=carrotlyl, createdTime=Thu Apr 29 10:01:48 CST 2021, time=2021-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920386, encodeId=973f92038676, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRvvXNvY0kOJqn4liar3Q6V6yPuEIawCVUyP3jVADh5icIz0ibrsxia6fKAqKsDr33jPWrjqM3D7wcRNu/0, createdBy=5a881701729, createdName=小树熊, createdTime=Wed Jan 27 19:39:31 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268400, encodeId=50661268400fc, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sat Jan 23 13:44:25 CST 2021, time=2021-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498814, encodeId=9c3614988146a, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sat Jan 23 13:44:25 CST 2021, time=2021-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918850, encodeId=4f9d9188503b, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Thu Jan 21 23:19:03 CST 2021, time=2021-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918849, encodeId=2b54918849e1, content=女性的心血管疾病(CVD)具有独特的特征,其与生殖之间的关联尚未完全明确。, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Thu Jan 21 22:52:21 CST 2021, time=2021-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918846, encodeId=df919188461f, content=已学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af965454834, createdName=ms7000001733098528, createdTime=Thu Jan 21 22:50:01 CST 2021, time=2021-01-21, status=1, ipAttribution=)]
    2021-01-23 zhaohui6731
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    2021-01-21 wxl882001

    了解

    0

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    2021-01-21 言西早

    女性的心血管疾病(CVD)具有独特的特征,其与生殖之间的关联尚未完全明确。

    0

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    2021-01-21 ms7000001733098528

    已学习

    0

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