J Periodontal Res:口腔炎症负载:口腔健康的标志物-中性粒细胞

2020-05-18 lishiting MedSci原创

由于发病率较高以及对系统疾病具有争论的有害作用,牙周疾病成为卫生保健系统的一项重大挑战。目前诊断牙周疾病的方法仅单纯的采用临床标准。这些方法不够精确,并且多少存在一定的侵入性。因此,很有必要研发一种非

由于发病率较高以及对系统疾病具有争论的有害作用,牙周疾病成为卫生保健系统的一项重大挑战。目前诊断牙周疾病的方法仅单纯的采用临床标准。这些方法不够精确,并且多少存在一定的侵入性。因此,很有必要研发一种非侵入性测试作为筛查和监测牙周疾病的方法

研究发现,口腔多形核中性粒细胞(oPMN)计数与口腔炎症程度以及牙周疾病的存在与严重程度相关。因而,oPMNs的定量对于鉴定和检测健康和牙周组织感染受试者的口腔炎症程度(oral inflammatory load; OIL)具有一定的潜力,它可以阐明较高oPMN计数与OIL程度/严重性之间存在正相关性。这些结果支持一种全新的非侵入性倚旁测试的发展与利用,它基于oPMN的数量(similar to white blood cell levels in blood as used in medicine for assessment of infection)可以快速、准确和客观的筛查OIL。在牙龈炎和牙周炎治疗前、中和后使用此种测试方法可以及时实施干预使病情得到改善,由此降低长期发病率。

原始出处:

William Khoury, Judah Glogauer, et al. Oral Inflammatory Load: Neutrophils as Oral Health Biomarkers. J Periodontal Res., 2020 May 6. doi: 10.1111/jre.12758.

 

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    2020-12-30 feather89
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    2020-05-23 502195270_41901995

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