Clin Gastroenterology H: 随机双盲试验证实抗生素不会减少单纯性憩室炎患者的住院时间

2021-02-27 MedSci原创 MedSci原创

在80岁以上的人群有三分之二的患者可能患有憩室炎病,其中有20%的患者存在明显的临床症状,急性憩室炎是老年患者急诊住院最常见的原因之一。

      在80岁以上的人群有三分之二的患者可能患有憩室炎病,其中有20%的患者存在明显的临床症状,急性憩室炎是老年患者急诊住院最常见的原因之一抗生素历来是急性憩室炎治疗的基本治疗药物,但是,实践表明基于抗生素的常规治疗在不存在并发症的急性憩室炎中的患者的疗效并不是很明显。本项研究旨在探究安慰剂与抗生素治疗无并发症性的急性憩室炎的疗效差异。

 

 

      研究人员将来自新西兰和澳大利亚的180例因单纯性急性憩室炎的患者随机分为接受抗生素(n = 85)或安慰剂(n = 95)的组,治疗持续7天。在收集了人口资料,临床和实验室数据后进行相关性分析,并在治疗前48小时内每12小时进行一次问卷调查,然后每天进行问卷调查直至出院。主要观察终点为住院时间。次要观察终点包括不良事件的发生,再次入院,炎症血清标志物的变化以及患者在12和24小时报告的疼痛评分等。

 

 

      研究结果显示接受抗生素治疗的患者与安慰剂组之间的中位住院时间无显着差异((40.0h; 95%CI,24.4–57.6h VS  45.8h; 95%CI,26.5–60.2h,P = 0.2 )。不良事件之间两组之间无显着差异(两组均为12%;P = 1.0),1周内再次入院(安慰剂组为1%,抗生素组为6%;P = 0.1),以及在30天内再次入院(安慰剂组为11%,抗生素组为6%;P = 0.3)均无显著差异。

 

 

      本项研究通过实验证实抗生素治疗并未减少憩室炎患者的住院时间。该项研究提供了有力的证据,表明那些无并发症的急性憩室炎患者可以不接受抗生素治疗。

 

 

 

原始出处:

Rebekah Jaung. Et al. Antibiotics Do Not Reduce Length of Hospital Stay for Uncomplicated Diverticulitis in a Pragmatic Double-Blind Randomized Trial. Clinical Gastroenterology and Hepatology.2021.

 

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    2021-12-05 许安
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    2021-03-01 科研科研科研

    抗生素不会减少患者的住院时间

    0

  5. 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    2021-03-01 zutt
  9. 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    2021-03-01 xlxchina
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    2021-03-01 妙酒

    人老了 身体机能退化是主要原因

    0

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