Sex Med:酒精对中老年男性磷酸二酯酶5抑制剂使用的影响

2020-04-25 MedSci原创 MedSci原创

先前的一些研究报道勃起功能障碍的患者通过与酒精一起摄入该药物来娱乐性使用5型磷酸二酯酶(PDE-5)抑制剂,但尚未研究一般人群的滥用率。本研究旨在调查普通男性人群中与PDE-5抑制剂同时饮酒的频率。我

先前的一些研究报道勃起功能障碍的患者通过与酒精一起摄入该药物来娱乐性使用5型磷酸二酯酶(PDE-5)抑制剂,但尚未研究一般人群的滥用率。本研究旨在调查普通男性人群中与PDE-5抑制剂同时饮酒的频率。我们第二次分析了酒精对PDE-5抑制剂的影响。

 

研究纳入了2016年1月至2018年2月在同一家医疗机构接受PDE-5抑制剂的325名勃起功能障碍的男性(34-78岁)。所有患者均完成了一项调查问卷,评估(i)平均饮酒量,(ii)先前与酒精一起使用PDE-5抑制剂和同时饮酒的目的,(iii)以及有关PDE-5抑制剂副作用的背景知识。

 

总共148例患者同时饮酒(第1组),而177例患者不饮酒(第2组)。关于使用的PDE-5抑制剂类型和潜在疾病,两组之间未观察到显著差异。与第1组相比,第2组有更多有关正确饮酒的正确知识的患者(24.9%比13.5%)。第一组的患者平均每周饮酒量超过15杯(64.8%比14.1%)。酗酒的原因是好奇心(35.1%),性欲增强(27%)和朋友的推荐(16.9%)。与第2组相比,第1组显示出明显更高的并发症,包括头痛(23.6%比7.3%)和面部潮红(69.6%比12.4%),第1组的1名患者出现严重的胸部不适并接受了冠状动脉造影,但无严重的阻塞性疾病观察到病变。

 

该结果表明,由于娱乐目的,有45.5%的中老年男性与酒精同时使用PDE-5抑制剂,滥用酒精可能会导致严重的并发症,包括胸部不适和头昏眼花。

 

原始出处:

 

Jong Nyeong KimJong Jin Oh, et al., Influence of Alcohol on Phosphodiesterase 5 inhibitors Use in Middle- to Old-Aged Men: A Comparative Study of Adverse Events. Sex Med. 2019 Dec; 7(4): 425–432. doi: 10.1016/j.esxm.2019.07.004

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    2020-07-05 jklm09
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    2020-04-27 智慧医人

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