CLIN CANCER RES:血清Nardilysin水平预测肝内胆管细胞癌患者预后

2019-01-27 MedSci MedSci原创

很少有研究寻找肝内胆管细胞癌(ICC)患者的预后生物标志物。Nardilysin(NRDC)是一种M16家族的金属内肽酶,被认为在炎症和几种癌症中发挥重要作用。CLIN CANCER RES近期发表了一篇文章,研究NRDC在ICC中的临床意义和生物学功能。

很少有研究寻找肝内胆管细胞癌(ICC)患者的预后生物标志物。Nardilysin(NRDC)是一种M16家族的金属内肽酶,被认为在炎症和几种癌症中发挥重要作用。CLIN CANCER RES近期发表了一篇文章,研究NRDC在ICC中的临床意义和生物学功能。

作者检测了两个独立的队列且进行手术切除的98名ICC患者的血清NRDC水平,评估其预后影响。作者还分析了43名ICC患者的癌组织标本中的NRDC mRNA水平。使用基因沉默方法研究NRDC在ICC细胞系中的细胞增殖,迁移,吉西他滨敏感性和基因表达中的作用。研究结果表明,高血清NRDC水平与初始组(n = 79)和验证组(n = 19)中较短的总生存期和无病生存期相关。血清蛋白水平和癌组织中NRDC mRNA水平之间存在相关性。ICC细胞系中敲低NRDC基因减弱了细胞增殖,迁移和肿瘤生长能力,并增加了对吉西他滨的敏感性。NRDC基因敲低还伴有几种上皮-间质转化(EMT)相关基因表达的显着变化。ICC患者的手术标本中,可以观察到NRDC和EMT诱导转录因子ZEB1和SNAI1的mRNA水平之间存在强烈相关性。

文章最后认为,血清NRDC是反映原发肿瘤EMT状态的可能的替代指标,可预测手术切除后ICC患者的临床结局。

原始出处:

Tomoaki Yoh, Etsuro Hatano, et al. Serum Nardilysin, a Surrogate Marker for Epithelial–Mesenchymal Transition, Predicts Prognosis of Intrahepatic Cholangiocarcinoma after Surgical Resection. CLIN CANCER RES. January 2019 doi: 0.1158/1078-0432.CCR-18-0124

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