lancet oncol:阿帕替尼联合依托泊苷用于铂类耐受性/难治性乳腺癌的效果和安全性

2018-08-04 MedSci MedSci原创

抗血管生成疗法与化疗相结合,可提高铂类耐药性卵巢癌患者的预后。阿帕替尼是一种口服的酪氨酸激酶抑制剂,可选择性抑制VEGF受体2。现有研究人员对阿帕替尼与口服依托泊苷联合用于铂类耐药性或难治性的卵巢癌患者的疗效和安全性进行评估。研究人员开展一前瞻性的单臂的2期试验,在中国中山大学癌症中心招募18-70岁的铂类耐药性或难治性的门诊卵巢癌患者。予以阿帕替尼(起始剂量500mg 1/日,连续用药)、依托泊

血管生成疗法与化疗相结合,可提高铂类耐药性卵巢癌患者的预后。阿帕替尼是一种口服的酪氨酸激酶抑制剂,可选择性抑制VEGF受体2。现有研究人员对阿帕替尼与口服依托泊苷联合用于铂类耐药性或难治性的卵巢癌患者的疗效和安全性进行评估。

研究人员开展一前瞻性的单臂的2期试验,在中国中山大学癌症中心招募18-70岁的铂类耐药性或难治性的门诊卵巢癌患者。予以阿帕替尼(起始剂量500mg 1/日,连续用药)、依托泊苷(500mg 1/日,每疗程的前14天用药),21天一疗程。依托泊苷最多用6个疗程。病程进展、患者退出试验或出现难以耐受的毒性作用时终止治疗。主要结点:获得客观缓解的患者比例。

2016年10月10日-2017年11月9日,共筛查了38位患者,招募了其中35位。截止2017年12月31日时,有20位(57%)患者终止治疗,15位(43%)患者仍在治疗中。35位患者中有19位(54%;95% CI 36.6-71.2)患者获得客观缓解,全部为符合协议的患者(总31位,61%,42.2-78.2)。最常见的3/4级副反应为中性粒细胞减少(17例[50%])、疲劳(11例[32%])、贫血(10例[29%])和粘膜炎(8例[24%])。两位患者出现严重副反应,住院治疗(1位是贫血和厌食、1位是病程进展导致腹水)。无治疗相关的死亡。

阿帕替尼联合口服依托泊苷用于铂类耐药性或难治性的卵巢癌患者疗效较好,副作用可控,现已获得批准进行3期临床试验。

原始出处:

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    2019-07-01 howi
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    2018-12-25 minlingfeng
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    2018-08-06 freve
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    2018-08-06 fengxx
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    2018-08-04 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

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