Science:搭载基因疗法的超级抗体!喷一喷鼻子抵御所有人类流感

2018-11-09 小通 生物通

斯克利普斯研究所的研究人员发现将四种抗体结合在一起可能是抵抗已知感染人类的所有类型流感病毒的有效策略。

斯克利普斯研究所的研究人员发现将四种抗体结合在一起可能是抵抗已知感染人类的所有类型流感病毒的有效策略。

该研究发表在Science在杂志上,表明,即使病毒突变迅速,这种策略也可能使流感预防工具在整个流感季节具有持续强度和效力。

“我们还没有疫苗来预防两种主要流感病毒(A和B,即甲型和乙型)。这项研究的关键是对A和B型流感病毒进行交叉中和多结构域的抗体工程,” 斯克利普斯研究所结构生物学教授,综合结构与计算生物学系主任 Ian Wilson说 。

抗体结合不是一个新概念,但这是第一次将四种抗体拴在一起并尝试抗流感。

本研究中的抗体来自骆驼,该骆驼曾接种含有三种病毒的疫苗以及来自两种不同流感病毒株的关键蛋白。骆驼在免疫学研究中很重要,因为它们产生独特的抗体,这些抗体比在人类中发现的抗体更小和更简单,并且适合于病毒表面更小和更凹陷的结合位点。

“在这种情况下,骆驼抗体可以容易地连接在一起,从而产生与不同靶标上的不同位点结合的多特异性抗体,”Ian Wilson 说。“这种多重特异性是广泛覆盖高变型病原体如流感的关键。”

科学家们将两种抗甲型流感的骆驼抗体和两种抗乙型流感的抗体结合在一起,创造出一种“多域”抗体。接下来,Ian Wilson与斯克利普斯研究所的同事Andrew Ward教授合作领导了X射线和电子显微镜结构研究,以准确显示这种多域抗体与流感病毒蛋白结合的位置。

他们发现抗体可以针对甲型流感病毒和乙型流感病毒的几个脆弱部位。这意味着该抗体具有交叉反应性,并且可能具有抵抗影响人类的所有循环病毒株以及可能突变导致大流行的新病毒亚型的能力。“接下来的问题是你如何传递这些抗体,”Ian Wilson说。

为此,科学家转向了传统的基因疗法,而不是疫苗设计。他们使用了一种病毒载体,这种载体可以传递一种经过特殊工程改造的基因,以指导细胞开始表达一种由来自所有四种骆驼抗体的片段组成的人造蛋白。

病毒载体,称为腺病毒相关病毒,然后通过鼻腔喷雾剂注入小鼠鼻孔。目的是让他们在上呼吸道产生这些保护性抗体,上呼吸道是最易感染流感的组织。由James Wilson和Maria Limberis博士等人发现,这种方法可以提供对多种流感毒株的保护,而且在大多数小鼠中,在几天之内它就迅速起作用了。

虽然这项研究表明多域抗体方法可能作为预防甲型和乙型流感的策略具有潜力,但这项研究是临床前研究,需要进一步研究以确定这种药物是否能够成功开发。

原始出处:Laursen NS1, Friesen RHE2, Zhu X1, et al. Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin. Science. 2018 Nov 2;362(6414):598-602. 

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    2018-11-17 shunshun_9

    学习了,谢谢

    0

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    2018-11-11 红色

    123

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    2018-11-11 红色

    123

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    2018-11-11 红色

    1

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  5. [GetPortalCommentsPageByObjectIdResponse(id=352892, encodeId=df6035289229, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20231124/fd91d920e9734e1294cfd0c801769fc5/f73f7f8747b84b76b12e1223886658ee.jpg, createdBy=32931458203, createdName=shunshun_9, createdTime=Sat Nov 17 21:16:20 CST 2018, time=2018-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352254, encodeId=932c35225470, content=123, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:51 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352253, encodeId=6736352253a9, content=123, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:48 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352252, encodeId=ebc03522525e, content=1, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:23 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352251, encodeId=e1f83522515c, content=1, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:21 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352250, encodeId=5bbb352250d9, content=1, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:19 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352249, encodeId=e1b835224924, content=123, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:17 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375888, encodeId=1c2313e58880f, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Sat Nov 10 17:00:00 CST 2018, time=2018-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352174, encodeId=f6433521e437, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Sat Nov 10 15:13:10 CST 2018, time=2018-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352160, encodeId=80de35216054, content=e!, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sat Nov 10 10:53:27 CST 2018, time=2018-11-10, status=1, ipAttribution=)]
    2018-11-11 红色

    1

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=352892, encodeId=df6035289229, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20231124/fd91d920e9734e1294cfd0c801769fc5/f73f7f8747b84b76b12e1223886658ee.jpg, createdBy=32931458203, createdName=shunshun_9, createdTime=Sat Nov 17 21:16:20 CST 2018, time=2018-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352254, encodeId=932c35225470, content=123, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:51 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352253, encodeId=6736352253a9, content=123, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:48 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352252, encodeId=ebc03522525e, content=1, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:23 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352251, encodeId=e1f83522515c, content=1, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:21 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352250, encodeId=5bbb352250d9, content=1, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:19 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352249, encodeId=e1b835224924, content=123, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:17 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375888, encodeId=1c2313e58880f, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Sat Nov 10 17:00:00 CST 2018, time=2018-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352174, encodeId=f6433521e437, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Sat Nov 10 15:13:10 CST 2018, time=2018-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352160, encodeId=80de35216054, content=e!, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sat Nov 10 10:53:27 CST 2018, time=2018-11-10, status=1, ipAttribution=)]
    2018-11-11 红色

    1

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=352892, encodeId=df6035289229, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20231124/fd91d920e9734e1294cfd0c801769fc5/f73f7f8747b84b76b12e1223886658ee.jpg, createdBy=32931458203, createdName=shunshun_9, createdTime=Sat Nov 17 21:16:20 CST 2018, time=2018-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352254, encodeId=932c35225470, content=123, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:51 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352253, encodeId=6736352253a9, content=123, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:48 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352252, encodeId=ebc03522525e, content=1, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:23 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352251, encodeId=e1f83522515c, content=1, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:21 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352250, encodeId=5bbb352250d9, content=1, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:19 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352249, encodeId=e1b835224924, content=123, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:17 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375888, encodeId=1c2313e58880f, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Sat Nov 10 17:00:00 CST 2018, time=2018-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352174, encodeId=f6433521e437, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Sat Nov 10 15:13:10 CST 2018, time=2018-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352160, encodeId=80de35216054, content=e!, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sat Nov 10 10:53:27 CST 2018, time=2018-11-10, status=1, ipAttribution=)]
    2018-11-11 红色

    123

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=352892, encodeId=df6035289229, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20231124/fd91d920e9734e1294cfd0c801769fc5/f73f7f8747b84b76b12e1223886658ee.jpg, createdBy=32931458203, createdName=shunshun_9, createdTime=Sat Nov 17 21:16:20 CST 2018, time=2018-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352254, encodeId=932c35225470, content=123, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:51 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352253, encodeId=6736352253a9, content=123, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:48 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352252, encodeId=ebc03522525e, content=1, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:23 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352251, encodeId=e1f83522515c, content=1, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:21 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352250, encodeId=5bbb352250d9, content=1, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:19 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352249, encodeId=e1b835224924, content=123, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:17 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375888, encodeId=1c2313e58880f, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Sat Nov 10 17:00:00 CST 2018, time=2018-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352174, encodeId=f6433521e437, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Sat Nov 10 15:13:10 CST 2018, time=2018-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352160, encodeId=80de35216054, content=e!, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sat Nov 10 10:53:27 CST 2018, time=2018-11-10, status=1, ipAttribution=)]
    2018-11-10 jichang
  9. [GetPortalCommentsPageByObjectIdResponse(id=352892, encodeId=df6035289229, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20231124/fd91d920e9734e1294cfd0c801769fc5/f73f7f8747b84b76b12e1223886658ee.jpg, createdBy=32931458203, createdName=shunshun_9, createdTime=Sat Nov 17 21:16:20 CST 2018, time=2018-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352254, encodeId=932c35225470, content=123, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:51 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352253, encodeId=6736352253a9, content=123, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:48 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352252, encodeId=ebc03522525e, content=1, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:23 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352251, encodeId=e1f83522515c, content=1, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:21 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352250, encodeId=5bbb352250d9, content=1, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:19 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352249, encodeId=e1b835224924, content=123, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sun Nov 11 09:55:17 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375888, encodeId=1c2313e58880f, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Sat Nov 10 17:00:00 CST 2018, time=2018-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352174, encodeId=f6433521e437, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Sat Nov 10 15:13:10 CST 2018, time=2018-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352160, encodeId=80de35216054, content=e!, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=080f2478288, createdName=红色, createdTime=Sat Nov 10 10:53:27 CST 2018, time=2018-11-10, status=1, ipAttribution=)]
    2018-11-10 Jackie Li

    学习

    0

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    2018-11-10 红色

    e!

    0

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