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J Periodontal Res：苯妥英钠改善牙龈成纤维细胞老化与自噬相关

2020-04-14 lishiting MedSci原创

自噬牙龈苯妥英钠
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人牙龈成纤维细胞老化是牙周疾病的一个重要原因。苯妥英钠(phenytoin)对牙龈存在副作用导致牙龈增生，对自噬进程也有一定的影响。这篇研究的目的是为了评估phenytoin对牙龈成纤维细胞老化的影响

人牙龈成纤维细胞老化是牙周疾病的一个重要原因。苯妥英钠(phenytoin)对牙龈存在副作用导致牙龈增生，对自噬进程也有一定的影响。这篇研究的目的是为了评估phenytoin对牙龈成纤维细胞老化的影响是否与自噬相关。

人牙龈成纤维细胞系HGF-1的老化模型通过过氧化氢(H2O2 )诱导形成，并同时施以phenytoin和3-methyladenine (3-MA)刺激。通过流式细胞仪检测细胞活性、细胞周期和细胞内钙离子水平。通过反转录聚合酶链式反应、WB和免疫荧光染色检测碱性成纤维细胞生长因子(bFGF)， P16INK4A， P21cip1和bFGF， P16INK4A， P21cip1， LC3II， p62和Beclin的表达变化。

结果显示，老化的HGF-1增殖受到H2O2的抑制，bFGF， P16INK4A和P21cip1基因和蛋白的表达减弱，自噬相关蛋白LC3II， p62和Becline的表达下调，G0/G1期比例以及细胞周期内的胞内钙离子水平下调。Phenytoin能够恢复上述的改变，但是其作用会被3-MA阻断。

结论：作者认为，phenytoin能够缓和H2O2诱导的牙龈成纤维细胞老化，并且与自噬相关。

原始出处：

Yi Kang， Ruhui Yang， et al. Phenytoin Sodium-Ameliorated Gingival Fibroblast Aging Is Associated With Autophagy. J Periodontal Res.， 2020 Apr 12. doi： 10.1111/jre.12750.

 

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    2021-06-22 粹尘

    药物性龈炎？

    0

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    2020-08-12 hb2008ye

    #牙龈成纤维细胞#

    0

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encodeId=8a3620e56138f, content=<a href='/topic/show?id=ae7d8e0598e' target=_blank style='color:#2F92EE;'>#苯妥英#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87059, encryptionId=ae7d8e0598e, topicName=苯妥英)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sat Oct 31 03:08:47 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307140, encodeId=7cc4130e1405f, content=<a href='/topic/show?id=6dab540565f' target=_blank style='color:#2F92EE;'>#成纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54056, encryptionId=6dab540565f, topicName=成纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Thu Apr 16 09:08:47 CST 2020, time=2020-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388041, encodeId=fb36138804142, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Apr 16 09:08:47 CST 2020, time=2020-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462825, encodeId=f21b14628255c, content=<a href='/topic/show?id=fbbce726228' target=_blank style='color:#2F92EE;'>#纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77262, encryptionId=fbbce726228, topicName=纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c516518840, createdName=marongnuan, createdTime=Thu Apr 16 09:08:47 CST 2020, time=2020-04-16, status=1, ipAttribution=)]
    2021-03-23 feather89

    #PE#

    0

  4. 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level=null, likeNumber=208, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87061, encryptionId=23e28e061a2, topicName=苯妥英钠 ), TopicDto(id=67723, encryptionId=79986e72382, topicName=牙龈), TopicDto(id=86109, encryptionId=049b86109ff, topicName=自噬), TopicDto(id=67515, encryptionId=5cc96e515a9, topicName=牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Nov 05 13:44:16 CST 2020, time=2020-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897084, encodeId=32d289e08496, content=#苯妥英钠#改善牙龈成纤维细胞老化与<a href='/topic/show?id=049b86109ff' target=_blank style='color:#2F92EE;'>#自噬#</a>相关。牙龈增生是一个古老的难题，苯妥英钠能否改造一下，成为牙周炎治疗的有效药物？？, beContent=null, objectType=article, channel=null, level=null, likeNumber=178, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87061, encryptionId=23e28e061a2, topicName=苯妥英钠 ), TopicDto(id=86109, encryptionId=049b86109ff, topicName=自噬)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Nov 05 13:44:01 CST 2020, time=2020-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2045501, encodeId=71332045501b3, content=<a href='/topic/show?id=a1b2e8002f8' target=_blank style='color:#2F92EE;'>#细胞老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78002, encryptionId=a1b2e8002f8, topicName=细胞老化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87f580, createdName=yilong5287542, createdTime=Sat Nov 28 19:08:47 CST 2020, time=2020-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075613, 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09:08:47 CST 2020, time=2020-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388041, encodeId=fb36138804142, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Apr 16 09:08:47 CST 2020, time=2020-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462825, encodeId=f21b14628255c, content=<a href='/topic/show?id=fbbce726228' target=_blank style='color:#2F92EE;'>#纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77262, encryptionId=fbbce726228, topicName=纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c516518840, createdName=marongnuan, createdTime=Thu Apr 16 09:08:47 CST 2020, time=2020-04-16, status=1, ipAttribution=)]
    2020-11-05 lovetcm

    #苯妥英钠#改善#牙龈#成纤维细胞老化与#自噬#相关。牙龈增生是一个古老的难题，苯妥英钠能否改造一下，成为#牙周炎#治疗的有效药物？？

    0

  5. 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encryptionId=23e28e061a2, topicName=苯妥英钠 ), TopicDto(id=86109, encryptionId=049b86109ff, topicName=自噬)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Nov 05 13:44:01 CST 2020, time=2020-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2045501, encodeId=71332045501b3, content=<a href='/topic/show?id=a1b2e8002f8' target=_blank style='color:#2F92EE;'>#细胞老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78002, encryptionId=a1b2e8002f8, topicName=细胞老化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87f580, createdName=yilong5287542, createdTime=Sat Nov 28 19:08:47 CST 2020, time=2020-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075613, encodeId=8a3620e56138f, content=<a href='/topic/show?id=ae7d8e0598e' target=_blank style='color:#2F92EE;'>#苯妥英#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87059, encryptionId=ae7d8e0598e, topicName=苯妥英)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sat Oct 31 03:08:47 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307140, encodeId=7cc4130e1405f, content=<a href='/topic/show?id=6dab540565f' target=_blank style='color:#2F92EE;'>#成纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54056, encryptionId=6dab540565f, topicName=成纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Thu Apr 16 09:08:47 CST 2020, time=2020-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388041, encodeId=fb36138804142, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Apr 16 09:08:47 CST 2020, time=2020-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462825, encodeId=f21b14628255c, content=<a href='/topic/show?id=fbbce726228' target=_blank style='color:#2F92EE;'>#纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77262, encryptionId=fbbce726228, topicName=纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c516518840, createdName=marongnuan, createdTime=Thu Apr 16 09:08:47 CST 2020, time=2020-04-16, status=1, ipAttribution=)]
    2020-11-05 lovetcm

    #苯妥英钠#改善牙龈成纤维细胞老化与#自噬#相关。牙龈增生是一个古老的难题，苯妥英钠能否改造一下，成为牙周炎治疗的有效药物？？

    0

  6. 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GetPortalCommentsPageByObjectIdResponse(id=1728412, encodeId=daa61e2841205, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Tue Mar 23 22:08:47 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897085, encodeId=299d89e0858e, content=#苯妥英钠#改善<a href='/topic/show?id=79986e72382' target=_blank style='color:#2F92EE;'>#牙龈#</a>成纤维细胞老化与<a href='/topic/show?id=049b86109ff' target=_blank style='color:#2F92EE;'>#自噬#</a>相关。牙龈增生是一个古老的难题，苯妥英钠能否改造一下，成为<a href='/topic/show?id=5cc96e515a9' target=_blank style='color:#2F92EE;'>#牙周炎#</a>治疗的有效药物？？, beContent=null, objectType=article, channel=null, level=null, likeNumber=208, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87061, encryptionId=23e28e061a2, topicName=苯妥英钠 ), TopicDto(id=67723, encryptionId=79986e72382, topicName=牙龈), TopicDto(id=86109, encryptionId=049b86109ff, topicName=自噬), TopicDto(id=67515, encryptionId=5cc96e515a9, topicName=牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Nov 05 13:44:16 CST 2020, time=2020-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897084, encodeId=32d289e08496, content=#苯妥英钠#改善牙龈成纤维细胞老化与<a href='/topic/show?id=049b86109ff' target=_blank style='color:#2F92EE;'>#自噬#</a>相关。牙龈增生是一个古老的难题，苯妥英钠能否改造一下，成为牙周炎治疗的有效药物？？, beContent=null, objectType=article, channel=null, level=null, likeNumber=178, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87061, encryptionId=23e28e061a2, topicName=苯妥英钠 ), TopicDto(id=86109, encryptionId=049b86109ff, topicName=自噬)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Nov 05 13:44:01 CST 2020, time=2020-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2045501, encodeId=71332045501b3, content=<a href='/topic/show?id=a1b2e8002f8' target=_blank style='color:#2F92EE;'>#细胞老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78002, encryptionId=a1b2e8002f8, topicName=细胞老化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87f580, createdName=yilong5287542, createdTime=Sat Nov 28 19:08:47 CST 2020, time=2020-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075613, encodeId=8a3620e56138f, content=<a href='/topic/show?id=ae7d8e0598e' target=_blank style='color:#2F92EE;'>#苯妥英#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87059, encryptionId=ae7d8e0598e, topicName=苯妥英)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sat Oct 31 03:08:47 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307140, encodeId=7cc4130e1405f, content=<a href='/topic/show?id=6dab540565f' target=_blank style='color:#2F92EE;'>#成纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54056, encryptionId=6dab540565f, topicName=成纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Thu Apr 16 09:08:47 CST 2020, time=2020-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388041, encodeId=fb36138804142, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Apr 16 09:08:47 CST 2020, time=2020-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462825, encodeId=f21b14628255c, content=<a href='/topic/show?id=fbbce726228' target=_blank style='color:#2F92EE;'>#纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77262, encryptionId=fbbce726228, topicName=纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c516518840, createdName=marongnuan, createdTime=Thu Apr 16 09:08:47 CST 2020, time=2020-04-16, status=1, ipAttribution=)]
    2020-11-28 yilong5287542

    #细胞老化#

    0

  7. 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GetPortalCommentsPageByObjectIdResponse(id=1728412, encodeId=daa61e2841205, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Tue Mar 23 22:08:47 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897085, encodeId=299d89e0858e, content=#苯妥英钠#改善<a href='/topic/show?id=79986e72382' target=_blank style='color:#2F92EE;'>#牙龈#</a>成纤维细胞老化与<a href='/topic/show?id=049b86109ff' target=_blank style='color:#2F92EE;'>#自噬#</a>相关。牙龈增生是一个古老的难题，苯妥英钠能否改造一下，成为<a href='/topic/show?id=5cc96e515a9' target=_blank style='color:#2F92EE;'>#牙周炎#</a>治疗的有效药物？？, beContent=null, objectType=article, channel=null, level=null, likeNumber=208, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87061, encryptionId=23e28e061a2, topicName=苯妥英钠 ), TopicDto(id=67723, encryptionId=79986e72382, topicName=牙龈), TopicDto(id=86109, encryptionId=049b86109ff, topicName=自噬), TopicDto(id=67515, encryptionId=5cc96e515a9, topicName=牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Nov 05 13:44:16 CST 2020, time=2020-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897084, encodeId=32d289e08496, content=#苯妥英钠#改善牙龈成纤维细胞老化与<a href='/topic/show?id=049b86109ff' target=_blank style='color:#2F92EE;'>#自噬#</a>相关。牙龈增生是一个古老的难题，苯妥英钠能否改造一下，成为牙周炎治疗的有效药物？？, beContent=null, objectType=article, channel=null, level=null, likeNumber=178, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87061, encryptionId=23e28e061a2, topicName=苯妥英钠 ), TopicDto(id=86109, encryptionId=049b86109ff, topicName=自噬)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Nov 05 13:44:01 CST 2020, time=2020-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2045501, encodeId=71332045501b3, content=<a href='/topic/show?id=a1b2e8002f8' target=_blank style='color:#2F92EE;'>#细胞老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78002, encryptionId=a1b2e8002f8, topicName=细胞老化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87f580, createdName=yilong5287542, createdTime=Sat Nov 28 19:08:47 CST 2020, time=2020-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075613, encodeId=8a3620e56138f, content=<a href='/topic/show?id=ae7d8e0598e' target=_blank style='color:#2F92EE;'>#苯妥英#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87059, encryptionId=ae7d8e0598e, topicName=苯妥英)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sat Oct 31 03:08:47 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307140, encodeId=7cc4130e1405f, content=<a href='/topic/show?id=6dab540565f' target=_blank style='color:#2F92EE;'>#成纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54056, encryptionId=6dab540565f, topicName=成纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Thu Apr 16 09:08:47 CST 2020, time=2020-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388041, encodeId=fb36138804142, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Apr 16 09:08:47 CST 2020, time=2020-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462825, encodeId=f21b14628255c, content=<a href='/topic/show?id=fbbce726228' target=_blank style='color:#2F92EE;'>#纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77262, encryptionId=fbbce726228, topicName=纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c516518840, createdName=marongnuan, createdTime=Thu Apr 16 09:08:47 CST 2020, time=2020-04-16, status=1, ipAttribution=)]
    2020-10-31 xiangyuzhou971

    #苯妥英#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=975896, encodeId=8c289e5896fe, content=药物性龈炎？, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=181a5531479, createdName=粹尘, createdTime=Tue Jun 22 19:37:53 CST 2021, time=2021-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1940939, encodeId=b194194093963, content=<a href='/topic/show?id=af226e73197' target=_blank style='color:#2F92EE;'>#牙龈成纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67731, encryptionId=af226e73197, topicName=牙龈成纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Wed Aug 12 05:08:47 CST 2020, time=2020-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728412, encodeId=daa61e2841205, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Tue Mar 23 22:08:47 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897085, encodeId=299d89e0858e, content=#苯妥英钠#改善<a href='/topic/show?id=79986e72382' target=_blank style='color:#2F92EE;'>#牙龈#</a>成纤维细胞老化与<a href='/topic/show?id=049b86109ff' target=_blank style='color:#2F92EE;'>#自噬#</a>相关。牙龈增生是一个古老的难题，苯妥英钠能否改造一下，成为<a href='/topic/show?id=5cc96e515a9' target=_blank style='color:#2F92EE;'>#牙周炎#</a>治疗的有效药物？？, beContent=null, objectType=article, channel=null, level=null, likeNumber=208, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87061, encryptionId=23e28e061a2, topicName=苯妥英钠 ), TopicDto(id=67723, encryptionId=79986e72382, topicName=牙龈), TopicDto(id=86109, encryptionId=049b86109ff, topicName=自噬), TopicDto(id=67515, encryptionId=5cc96e515a9, topicName=牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Nov 05 13:44:16 CST 2020, time=2020-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897084, encodeId=32d289e08496, content=#苯妥英钠#改善牙龈成纤维细胞老化与<a href='/topic/show?id=049b86109ff' target=_blank style='color:#2F92EE;'>#自噬#</a>相关。牙龈增生是一个古老的难题，苯妥英钠能否改造一下，成为牙周炎治疗的有效药物？？, beContent=null, objectType=article, channel=null, level=null, likeNumber=178, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87061, encryptionId=23e28e061a2, topicName=苯妥英钠 ), TopicDto(id=86109, encryptionId=049b86109ff, topicName=自噬)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Nov 05 13:44:01 CST 2020, time=2020-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2045501, encodeId=71332045501b3, content=<a href='/topic/show?id=a1b2e8002f8' target=_blank style='color:#2F92EE;'>#细胞老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78002, encryptionId=a1b2e8002f8, topicName=细胞老化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87f580, createdName=yilong5287542, createdTime=Sat Nov 28 19:08:47 CST 2020, time=2020-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075613, encodeId=8a3620e56138f, content=<a href='/topic/show?id=ae7d8e0598e' target=_blank style='color:#2F92EE;'>#苯妥英#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87059, encryptionId=ae7d8e0598e, topicName=苯妥英)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sat Oct 31 03:08:47 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307140, encodeId=7cc4130e1405f, content=<a href='/topic/show?id=6dab540565f' target=_blank style='color:#2F92EE;'>#成纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54056, encryptionId=6dab540565f, topicName=成纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Thu Apr 16 09:08:47 CST 2020, time=2020-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388041, encodeId=fb36138804142, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Apr 16 09:08:47 CST 2020, time=2020-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462825, encodeId=f21b14628255c, content=<a href='/topic/show?id=fbbce726228' target=_blank style='color:#2F92EE;'>#纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77262, encryptionId=fbbce726228, topicName=纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c516518840, createdName=marongnuan, createdTime=Thu Apr 16 09:08:47 CST 2020, time=2020-04-16, status=1, ipAttribution=)]
    2020-04-16 zhishijing

    #成纤维细胞#

    0

  9. 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09:08:47 CST 2020, time=2020-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388041, encodeId=fb36138804142, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Apr 16 09:08:47 CST 2020, time=2020-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462825, encodeId=f21b14628255c, content=<a href='/topic/show?id=fbbce726228' target=_blank style='color:#2F92EE;'>#纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77262, encryptionId=fbbce726228, topicName=纤维细胞)], attachment=null, 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    2020-04-16 heli0118

    #老化#

    0

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    2020-04-16 marongnuan

    #纤维细胞#

    0

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