Colorectal Dis:多普勒引导目标导向性液体治疗增加结直肠手术的整体胃肠灌注程度

2017-12-08 MedSci MedSci原创

研究认为术中以及术后1小时内多普勒引导目标导向性液体治疗,可提高结直肠手术患者的胃肠道灌注效果

个体化目标导向性液体治疗(GDFT)可减少肠道手术后的并发症、死亡率并缩短住院时间。近日研究人员考察了多普勒引导的GDFT与常规输液相比对胃肠道损伤及灌注效果的差异。

因肿瘤进行选择性结直肠切除术患者参与研究,患者随机接受标准术中和术后液体疗法或多普勒引导的GDFT。研究的主要终点是I-FABP测定的肠胃道细胞损伤以及通过胃张力计测定全胃肠灌注,表现为胃区域动脉CO2压力差(Pr-aCO2-gap)。

研究发现,组间I-FABP 水平无显著差异(440.8 (251.6) pg/ml vs 522.4 (759.9) pg/ml, P = 0.67),但GDFT组术中Pr-aCO2-gap的曲线下面积显著低于对照组,表明GDFT组胃肠灌注程度更充分。此外,GDFT组术中Pr-aCO2-gap峰值压力为0.5kPa,显著低于对照组的1.4kPa (P = 0.03)。

研究认为术中以及术后1小时内多普勒引导目标导向性液体治疗,可提高结直肠手术患者的胃肠道灌注效果。

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    2018-09-18 shalley66
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    2018-08-03 windight
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