Obstet Gynecol:孕产妇肥胖与妊娠早期和晚期高血压疾病风险

2020-06-16 MedSci原创 MedSci原创

与非肥胖孕妇相比,随着肥胖等级增加,肥胖孕妇妊娠早发和晚发性高血压疾病的风险也逐渐增加。

近日,妇产科权威杂志Obstetrics and Gynecology上发表了一篇研究文章,研究人员旨在评估分娩时孕妇体重指数(BMI)与妊娠早期和晚期高血压疾病发生率之间的关系。

研究人员使用2014年至2017年期间的美国生命统计数据与时间相关的出生和婴儿死亡证明进行了一项基于人群的回顾性队列研究,其中纳入了从妊娠24周到41周完成非异常单胎的孕妇。研究人员排除了患有慢性高血压的妇女以及BMI低于18.5的妇女。该研究的主要暴露因素是母亲BMI,分为非肥胖(BMI为18.5-29.9;参考人群)、1级肥胖(BMI为30.0-34.9)、2级肥胖(BMI为35.0-39.9)和3级肥胖(BMI超过40.0) 。该研究的主要结局是在妊娠少于34周或大于或等于34周时的妊娠高血压疾病(妊娠高血压、先兆子痫或子痫)。多变量泊松回归用来估计相关风险并调整混杂变量。结果以调整后的相对风险(aRR)和95%CI表示。

在研究期间的1580万活产孕妇中,有1400万(88.6%)孕妇符合纳入标准,而825722名(5.9%)孕妇患有高血压疾病。与非肥胖孕妇相比,1级肥胖(aRR为1.13;95%CI为1.10-1.16)、2级肥胖(aRR为1.57;95%CI为1.53-1.62)和3级肥胖(aRR为2.18;95%CI为2.12-2.24)孕妇妊娠早期高血压疾病的风险明显更高。与非肥胖孕妇相比,1级肥胖(aRR为1.71;95%CI为1.70–1.73)、2级肥胖(aRR为2.60; 95%CI为2.58–2.62)和3级肥胖(aRR为3.93;95%CI为3.91-3.96)孕妇妊娠晚期高血压疾病的风险也显著增加。

由此可见,与非肥胖孕妇相比,随着肥胖等级增加,肥胖孕妇妊娠早发和晚发性高血压疾病的风险也逐渐增加。

原始出处:

Bicocca, Matthew J.et al.Maternal Obesity and the Risk of Early-Onset and Late-Onset Hypertensive Disorders of Pregnancy.Obstetrics & Gynecology.2020.https://journals.lww.com/greenjournal/Abstract/9000/Maternal_Obesity_and_the_Risk_of_Early_Onset_and.97316.aspx

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