Neurology:癫痫持续时间与癫痫手术中癫痫发作结局

2019-06-11 xing.T 网络

由此可见,癫痫持续时间较短的患者在随访时更容易发生癫痫发作。此外,对于非常长的癫痫持续时间,持续时间较短和癫痫发作自由之间存在正相关性。因此,无论癫痫持续时间如何,都可以将接受癫痫手术的患者转诊进行术前评估,不会再有延误。证据的低确定性存在研究异质性和可能的​​残余混杂的担忧。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员对早期或晚期切除性癫痫手术对癫痫发作结局的影响进行了系统评价和荟萃分析。

研究人员检索了PubMed、EMBASE和Cochrane图书馆的电子数据库,用于研究癫痫持续时间与切除手术后癫痫发作自由度之间的关系。两位评价员独立筛选了引用文献的资格,并评估了相关研究的偏倚风险。研究人员使用随机效应模型将数据组合在Meta分析中。研究人员根据GRADE评分确定了证据的确定性。 

该分析纳入了25项研究,其中12项具有适合荟萃分析的数据。比较癫痫手术在癫痫持续时间为2年、5年、10年和20年之后的癫痫发作结局,并比较癫痫持续时间<5年至>10年,研究人员发现持续时间较短具有益处,且风险差异从0.15到 0.21,风险比从1.20到1.33(所有比较p<0.01)。根据GRADE,研究人员发现低确定性的证据支持术前维持较短的癫痫持续时间。

由此可见,癫痫持续时间较短的患者在随访时更容易发生癫痫发作。此外,对于非常长的癫痫持续时间,持续时间较短和癫痫发作自由之间存在正相关性。因此,无论癫痫持续时间如何,都可以将接受癫痫手术的患者转诊进行术前评估,不会再有延误。证据的低确定性存在研究异质性和可能的​​残余混杂的担忧。 

原始出处:

Johan Bjellvi,et al.Epilepsy duration and seizure outcome in epilepsy surgery A systematic review and meta-analysis.Neurology.2019.https://n.neurology.org/content/early/2019/06/09/WNL.0000000000007753

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    2019-11-26 yinhl1978
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