JAHA:短暂性脑缺血发作和缺血性脑卒中后新发房颤对比

2021-03-10 MedSci原创 MedSci原创

在脑缺血患者中,TIA和轻度卒中之间的区别并没有对随后诊断AF的风险进行分层,这意味着TIA患者应该和缺血性卒中患者一样接受类似的心律监测。

短暂性脑缺血发作(TIA)后房颤(AF)的临床特征尚未得到较好的归纳。近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在比较缺血性脑卒中和TIA后新发AF诊断的几率。

新发TIA和轻度缺血性卒中患者应用血小板定向抑制(POINT)试验纳入了轻度缺血性卒中或高风险TIA成年患者。该研究的暴露因素为指定的事件类型(缺血性中风 vs. TIA)。该研究的主要分析使用了试验最初的TIA定义(症状/体征)。在次要分析中,在神经影像学检查结果上伴有梗死的TIA病例被重新归类为卒中病例。

该研究的主要结局是从不良事件和治疗中断/停止报告中确定的新发AF诊断。研究人员计算了新近诊断AF相关变量的C-统计值,并使用Kaplan-Meier生存数据和Cox模型对人口统计学和血管危险因素进行了调整。

除49例基线AF患者外,2746例为卒中患者,2086例为TIA患者。在90天的随访中,106名患者首次诊断AF。卒中后AF累积风险为2.7% (95%CI为2.1%-3.4%),TIA后AF累积风险为2.0% (95%CI为1.5%-2.7%) (P=0.15)。根据神经影像学检查结果对事件重新分类后,卒中后AF的累积风险(2.7%;95%CI为2.2%-3.4%)高于TIA (1.8%;95%CI为1.3%-2.5%) (P=0.04)。事件类型的预测效用可以忽略不计(C‐统计值为0.54)。

由此可见,在脑缺血患者中,TIA和轻度卒中之间的区别并没有对随后诊断AF的风险进行分层,这意味着TIA患者应该和缺血性卒中患者一样接受类似的心律监测

原始出处:

Hooman Kamel.et al.Newly Diagnosed Atrial Fibrillation After Transient Ischemic Attack Versus Minor Ischemic Stroke in the POINT Trial.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/10.1161/JAHA.120.019362

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  5. 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  6. 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  7. 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createdName=zhaohui6731, createdTime=Thu Mar 11 15:06:23 CST 2021, time=2021-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289252, encodeId=efc71289252e8, content=<a href='/topic/show?id=cd268500578' target=_blank style='color:#2F92EE;'>#脑缺血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85005, encryptionId=cd268500578, topicName=脑缺血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=845e216, createdName=cqlidoudou, createdTime=Thu Mar 11 15:06:23 CST 2021, time=2021-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481392, encodeId=34b71481392b3, content=<a href='/topic/show?id=ce0258131ff' target=_blank style='color:#2F92EE;'>#新发房颤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58131, encryptionId=ce0258131ff, topicName=新发房颤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=788d7780866, createdName=若水125, createdTime=Thu Mar 11 15:06:23 CST 2021, time=2021-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026787, encodeId=34ff1026e87c1, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Wed Mar 10 03:06:23 CST 2021, time=2021-03-10, status=1, ipAttribution=)]
    2021-03-11 zhaohui6731
  8. 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  9. 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GetPortalCommentsPageByObjectIdResponse(id=1764552, encodeId=99651e64552c1, content=<a href='/topic/show?id=1612e319263' target=_blank style='color:#2F92EE;'>#短暂性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73192, encryptionId=1612e319263, topicName=短暂性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b6237741961, createdName=12498ca5m95暂无昵称, createdTime=Fri Feb 11 09:06:23 CST 2022, time=2022-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268450, encodeId=7869126845098, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Mar 11 15:06:23 CST 2021, time=2021-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289252, encodeId=efc71289252e8, content=<a href='/topic/show?id=cd268500578' target=_blank style='color:#2F92EE;'>#脑缺血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85005, encryptionId=cd268500578, topicName=脑缺血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=845e216, createdName=cqlidoudou, createdTime=Thu Mar 11 15:06:23 CST 2021, time=2021-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481392, encodeId=34b71481392b3, content=<a href='/topic/show?id=ce0258131ff' target=_blank style='color:#2F92EE;'>#新发房颤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58131, encryptionId=ce0258131ff, topicName=新发房颤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=788d7780866, createdName=若水125, createdTime=Thu Mar 11 15:06:23 CST 2021, time=2021-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026787, encodeId=34ff1026e87c1, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Wed Mar 10 03:06:23 CST 2021, time=2021-03-10, status=1, ipAttribution=)]
    2021-03-10 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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