JAHA:高敏肌钙蛋白I可以提高老年人心血管风险的预测价值

2019-03-02 不详 MedSci原创

Framingham风险评分可以预测评估患者10年的心血管疾病风险,但其在年龄很大的成年人中预测价值较低。本研究的目的旨在评估联合心脏高敏肌钙蛋白I(hs-cTnI)和Framingham风险评分的价值。本研究纳入了HIMS临床研究中的70-89岁参与者,并对1151名无心血管疾病史的男性进行了hs-cTnI的检测,经过10年时间的随访,有252名男性(22%)有心血管疾病(CVE+),有899名

Framingham风险评分可以预测评估患者10年的血管疾病风险,但其在年龄很大的成年人中预测价值较低。本研究的目的旨在评估联合心脏高敏肌钙蛋白I(hs-cTnI)和Framingham风险评分的价值。

本研究纳入了HIMS临床研究中的70-89岁参与者,并对1151名无血管疾病史的男性进行了hs-cTnI的检测,经过10年时间的随访,有252名男性(22%)有心血管疾病(CVE+),有899名无心血管疾病(CVE-)。Framingham风险评分预测对了148 (59%)例CVE+和415 (46%) 例CVE–。在CVE–患者中,添加hs-cTnI检测可以将高风险人群降低至39%,在CVE+患者中,增加hs-cTnI影响了61名患者的风险类别(24.2%),50.8%的风险类别被适当地重新分类为更高的风险类别,49.2%的风险类别被重新分类为更低的风险类别,82.5%的风险类别仍高于15%的风险处理阈值。另外,添加hs-cTnI可以提高预测模型的适合度。

研究结果显示,联合心脏高敏肌钙蛋白I和Framingham风险评分可以提高老年人的心血管风险预测价值。

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