DCR:二甲双胍作为放射增敏剂在直肠癌新辅助治疗中的作用

2020-09-10 MedSci原创 MedSci原创

二甲双胍是治疗Ⅱ型糖尿病最常用的处方药,因为它可以它通过抑制肝脏葡萄糖的产生而具有降低血糖的作用,是目前全球应用最广泛的口服降糖药之一。

        二甲双胍是治疗Ⅱ型糖尿病最常用的处方药,因为它可以它通过抑制肝脏葡萄糖的产生而具有降低血糖的作用,是目前全球应用最广泛的口服降糖药之一。作为一个老药,与“神药”阿司匹林一样,人们对于二甲双胍的研究从未停止过,研究热度也是日益高涨,而二甲双胍也总是不断地刷新我们对它的认知,并持续给人们带来一个又一个的惊喜。

 

        近期,有研究人员发现,直肠癌患者在放疗期间服用二甲双胍有助于增强放疗的治疗效果。研究人员将三种不同癌系的细胞SW480,HT29和HCT116作为体外实验品分别与二甲双胍共培养并在射线的照射下观察癌细胞的生长情况由此来判断二甲双胍是否有助于增强放疗的治疗效果。研究结果显示所有细胞系在用二甲双胍进行治疗后均显着降低了细胞活力。与单独的辐射相比,二甲双胍+辐射的治疗组的放射治疗效果明显更好(37% VS 74%; p <0.001),但是由于5氟尿嘧啶(5-FU)毒性增加(≤细胞活力的20%)。体内试验表明放射/二甲双胍治疗与放射/ 5FU(557vs398mm3,p> 0.05)效果相当,并且在标准放射/ 5FU中添加二甲双胍不能改善肿瘤反应。

 

        最后研究人员说道:二甲双胍可增强体内外肿瘤对放射线的反应,是一种有前景的的替代放射增敏剂。

 

原始出处:

Fernandes. Et al. Metformin as an Alternative Radiosensitizing Agent to 5-Fluorouracil During Neoadjuvant Treatment for Rectal Cancer. Diseases of the Colon & Rectum.2020.

 

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1678641, encodeId=ebdc16e864126, content=<a href='/topic/show?id=110c5869153' target=_blank style='color:#2F92EE;'>#新辅助#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58691, encryptionId=110c5869153, topicName=新辅助)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=941f27706894, createdName=charl1234576, createdTime=Mon Jan 18 12:53:10 CST 2021, time=2021-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899742, encodeId=2c81899e423d, content=期待有更多证据的支持, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=73095435589, createdName=ms3000001718603800, createdTime=Mon Nov 16 23:42:08 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884355, encodeId=8e5e884355e1, content=<a href='/topic/show?id=ce9d239823b' target=_blank style='color:#2F92EE;'>#二甲双胍#</a>已经成为国民神药,结果令人可喜。, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23982, encryptionId=ce9d239823b, topicName=二甲双胍)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200901/629d1ce7d6f64d17a642c37c90dea72c/202f9333a3ea4b23a9b07ede3364e86b.jpg, createdBy=1a335163906, createdName=Sunny orchard, createdTime=Thu Sep 10 22:23:57 CST 2020, time=2020-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884341, encodeId=fb928843412d, content= <a href='/topic/show?id=ce9d239823b' target=_blank style='color:#2F92EE;'>#二甲双胍#</a> 真的是神药呀! 好多功能!, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23982, encryptionId=ce9d239823b, topicName=二甲双胍)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Sep 10 21:57:49 CST 2020, time=2020-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041549, encodeId=093b104154971, content=二甲双胍,神药!, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Sep 10 19:53:10 CST 2020, time=2020-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884266, encodeId=8b0288426644, content=<a href='/topic/show?id=ce9d239823b' target=_blank style='color:#2F92EE;'>#二甲双胍#</a>作为<a href='/topic/show?id=a18d1038857c' target=_blank style='color:#2F92EE;'>#放射增敏剂#</a>在<a href='/topic/show?id=51cbe247518' target=_blank style='color:#2F92EE;'>#直肠癌#</a><a href='/topic/show?id=1a5a58e00ad' target=_blank style='color:#2F92EE;'>#新辅助治疗#</a>中起作用,事实上,在化疗的新辅助治疗或治疗中,同样有作用,也不仅仅是<a href='/topic/show?id=493ae869206' target=_blank style='color:#2F92EE;'>#结直肠癌#</a>,在<a href='/topic/show?id=f9e2832202f' target=_blank style='color:#2F92EE;'>#胃癌#</a>,<a href='/topic/show?id=384b8220449' target=_blank style='color:#2F92EE;'>#肺癌#</a>也可能起重要的作用。二甲双胍可以作为癌症的重要的辅助治疗措施, beContent=null, objectType=article, channel=null, level=null, likeNumber=301, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23982, encryptionId=ce9d239823b, topicName=二甲双胍), TopicDto(id=103885, encryptionId=a18d1038857c, topicName=放射增敏剂), TopicDto(id=72475, encryptionId=51cbe247518, topicName=直肠癌), TopicDto(id=58700, encryptionId=1a5a58e00ad, topicName=新辅助治疗), TopicDto(id=78692, encryptionId=493ae869206, topicName=结直肠癌), TopicDto(id=83220, encryptionId=f9e2832202f, topicName=胃癌), TopicDto(id=82204, encryptionId=384b8220449, topicName=肺癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Sep 10 17:09:40 CST 2020, time=2020-09-10, status=1, ipAttribution=)]
    2020-11-16 ms3000001718603800

    期待有更多证据的支持

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1678641, encodeId=ebdc16e864126, content=<a href='/topic/show?id=110c5869153' target=_blank style='color:#2F92EE;'>#新辅助#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58691, encryptionId=110c5869153, topicName=新辅助)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=941f27706894, createdName=charl1234576, createdTime=Mon Jan 18 12:53:10 CST 2021, time=2021-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899742, encodeId=2c81899e423d, content=期待有更多证据的支持, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=73095435589, createdName=ms3000001718603800, createdTime=Mon Nov 16 23:42:08 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884355, encodeId=8e5e884355e1, content=<a href='/topic/show?id=ce9d239823b' target=_blank style='color:#2F92EE;'>#二甲双胍#</a>已经成为国民神药,结果令人可喜。, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23982, encryptionId=ce9d239823b, topicName=二甲双胍)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200901/629d1ce7d6f64d17a642c37c90dea72c/202f9333a3ea4b23a9b07ede3364e86b.jpg, createdBy=1a335163906, createdName=Sunny orchard, createdTime=Thu Sep 10 22:23:57 CST 2020, time=2020-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884341, encodeId=fb928843412d, content= <a href='/topic/show?id=ce9d239823b' target=_blank style='color:#2F92EE;'>#二甲双胍#</a> 真的是神药呀! 好多功能!, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23982, encryptionId=ce9d239823b, topicName=二甲双胍)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Sep 10 21:57:49 CST 2020, time=2020-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041549, encodeId=093b104154971, content=二甲双胍,神药!, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Sep 10 19:53:10 CST 2020, time=2020-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884266, encodeId=8b0288426644, content=<a href='/topic/show?id=ce9d239823b' target=_blank style='color:#2F92EE;'>#二甲双胍#</a>作为<a href='/topic/show?id=a18d1038857c' target=_blank style='color:#2F92EE;'>#放射增敏剂#</a>在<a href='/topic/show?id=51cbe247518' target=_blank style='color:#2F92EE;'>#直肠癌#</a><a href='/topic/show?id=1a5a58e00ad' target=_blank style='color:#2F92EE;'>#新辅助治疗#</a>中起作用,事实上,在化疗的新辅助治疗或治疗中,同样有作用,也不仅仅是<a href='/topic/show?id=493ae869206' target=_blank style='color:#2F92EE;'>#结直肠癌#</a>,在<a href='/topic/show?id=f9e2832202f' target=_blank style='color:#2F92EE;'>#胃癌#</a>,<a href='/topic/show?id=384b8220449' target=_blank style='color:#2F92EE;'>#肺癌#</a>也可能起重要的作用。二甲双胍可以作为癌症的重要的辅助治疗措施, beContent=null, objectType=article, channel=null, level=null, likeNumber=301, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23982, encryptionId=ce9d239823b, topicName=二甲双胍), TopicDto(id=103885, encryptionId=a18d1038857c, topicName=放射增敏剂), TopicDto(id=72475, encryptionId=51cbe247518, topicName=直肠癌), TopicDto(id=58700, encryptionId=1a5a58e00ad, topicName=新辅助治疗), TopicDto(id=78692, encryptionId=493ae869206, topicName=结直肠癌), TopicDto(id=83220, encryptionId=f9e2832202f, topicName=胃癌), TopicDto(id=82204, encryptionId=384b8220449, topicName=肺癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Sep 10 17:09:40 CST 2020, time=2020-09-10, status=1, ipAttribution=)]
    2020-09-10 Sunny orchard

    #二甲双胍#已经成为国民神药,结果令人可喜。

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1678641, encodeId=ebdc16e864126, content=<a href='/topic/show?id=110c5869153' target=_blank style='color:#2F92EE;'>#新辅助#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58691, encryptionId=110c5869153, topicName=新辅助)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=941f27706894, createdName=charl1234576, createdTime=Mon Jan 18 12:53:10 CST 2021, time=2021-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899742, encodeId=2c81899e423d, content=期待有更多证据的支持, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=73095435589, createdName=ms3000001718603800, createdTime=Mon Nov 16 23:42:08 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884355, encodeId=8e5e884355e1, content=<a href='/topic/show?id=ce9d239823b' target=_blank style='color:#2F92EE;'>#二甲双胍#</a>已经成为国民神药,结果令人可喜。, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23982, encryptionId=ce9d239823b, topicName=二甲双胍)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200901/629d1ce7d6f64d17a642c37c90dea72c/202f9333a3ea4b23a9b07ede3364e86b.jpg, createdBy=1a335163906, createdName=Sunny orchard, createdTime=Thu Sep 10 22:23:57 CST 2020, time=2020-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884341, encodeId=fb928843412d, content= <a href='/topic/show?id=ce9d239823b' target=_blank style='color:#2F92EE;'>#二甲双胍#</a> 真的是神药呀! 好多功能!, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23982, encryptionId=ce9d239823b, topicName=二甲双胍)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Sep 10 21:57:49 CST 2020, time=2020-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041549, encodeId=093b104154971, content=二甲双胍,神药!, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Sep 10 19:53:10 CST 2020, time=2020-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884266, encodeId=8b0288426644, content=<a href='/topic/show?id=ce9d239823b' target=_blank style='color:#2F92EE;'>#二甲双胍#</a>作为<a href='/topic/show?id=a18d1038857c' target=_blank style='color:#2F92EE;'>#放射增敏剂#</a>在<a href='/topic/show?id=51cbe247518' target=_blank style='color:#2F92EE;'>#直肠癌#</a><a href='/topic/show?id=1a5a58e00ad' target=_blank style='color:#2F92EE;'>#新辅助治疗#</a>中起作用,事实上,在化疗的新辅助治疗或治疗中,同样有作用,也不仅仅是<a href='/topic/show?id=493ae869206' target=_blank style='color:#2F92EE;'>#结直肠癌#</a>,在<a href='/topic/show?id=f9e2832202f' target=_blank style='color:#2F92EE;'>#胃癌#</a>,<a href='/topic/show?id=384b8220449' target=_blank style='color:#2F92EE;'>#肺癌#</a>也可能起重要的作用。二甲双胍可以作为癌症的重要的辅助治疗措施, beContent=null, objectType=article, channel=null, level=null, likeNumber=301, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23982, encryptionId=ce9d239823b, topicName=二甲双胍), TopicDto(id=103885, encryptionId=a18d1038857c, topicName=放射增敏剂), TopicDto(id=72475, encryptionId=51cbe247518, topicName=直肠癌), TopicDto(id=58700, encryptionId=1a5a58e00ad, topicName=新辅助治疗), TopicDto(id=78692, encryptionId=493ae869206, topicName=结直肠癌), TopicDto(id=83220, encryptionId=f9e2832202f, topicName=胃癌), TopicDto(id=82204, encryptionId=384b8220449, topicName=肺癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Sep 10 17:09:40 CST 2020, time=2020-09-10, status=1, ipAttribution=)]
    2020-09-10 Jessica

    #二甲双胍# 真的是神药呀! 好多功能!

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1678641, encodeId=ebdc16e864126, content=<a href='/topic/show?id=110c5869153' target=_blank style='color:#2F92EE;'>#新辅助#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58691, encryptionId=110c5869153, topicName=新辅助)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=941f27706894, createdName=charl1234576, createdTime=Mon Jan 18 12:53:10 CST 2021, time=2021-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899742, encodeId=2c81899e423d, content=期待有更多证据的支持, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=73095435589, createdName=ms3000001718603800, createdTime=Mon Nov 16 23:42:08 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884355, encodeId=8e5e884355e1, content=<a href='/topic/show?id=ce9d239823b' target=_blank style='color:#2F92EE;'>#二甲双胍#</a>已经成为国民神药,结果令人可喜。, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23982, encryptionId=ce9d239823b, topicName=二甲双胍)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200901/629d1ce7d6f64d17a642c37c90dea72c/202f9333a3ea4b23a9b07ede3364e86b.jpg, createdBy=1a335163906, createdName=Sunny orchard, createdTime=Thu Sep 10 22:23:57 CST 2020, time=2020-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884341, encodeId=fb928843412d, content= <a href='/topic/show?id=ce9d239823b' target=_blank style='color:#2F92EE;'>#二甲双胍#</a> 真的是神药呀! 好多功能!, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23982, encryptionId=ce9d239823b, topicName=二甲双胍)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Sep 10 21:57:49 CST 2020, time=2020-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041549, encodeId=093b104154971, content=二甲双胍,神药!, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Sep 10 19:53:10 CST 2020, time=2020-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884266, encodeId=8b0288426644, content=<a href='/topic/show?id=ce9d239823b' target=_blank style='color:#2F92EE;'>#二甲双胍#</a>作为<a href='/topic/show?id=a18d1038857c' target=_blank style='color:#2F92EE;'>#放射增敏剂#</a>在<a href='/topic/show?id=51cbe247518' target=_blank style='color:#2F92EE;'>#直肠癌#</a><a href='/topic/show?id=1a5a58e00ad' target=_blank style='color:#2F92EE;'>#新辅助治疗#</a>中起作用,事实上,在化疗的新辅助治疗或治疗中,同样有作用,也不仅仅是<a href='/topic/show?id=493ae869206' target=_blank style='color:#2F92EE;'>#结直肠癌#</a>,在<a href='/topic/show?id=f9e2832202f' target=_blank style='color:#2F92EE;'>#胃癌#</a>,<a href='/topic/show?id=384b8220449' target=_blank style='color:#2F92EE;'>#肺癌#</a>也可能起重要的作用。二甲双胍可以作为癌症的重要的辅助治疗措施, beContent=null, objectType=article, channel=null, level=null, likeNumber=301, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23982, encryptionId=ce9d239823b, topicName=二甲双胍), TopicDto(id=103885, encryptionId=a18d1038857c, topicName=放射增敏剂), TopicDto(id=72475, encryptionId=51cbe247518, topicName=直肠癌), TopicDto(id=58700, encryptionId=1a5a58e00ad, topicName=新辅助治疗), TopicDto(id=78692, encryptionId=493ae869206, topicName=结直肠癌), TopicDto(id=83220, encryptionId=f9e2832202f, topicName=胃癌), TopicDto(id=82204, encryptionId=384b8220449, topicName=肺癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Sep 10 17:09:40 CST 2020, time=2020-09-10, status=1, ipAttribution=)]
    2020-09-10 misszhang

    二甲双胍,神药!

    0

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    2020-09-10 lovetcm

    #二甲双胍#作为#放射增敏剂##直肠癌##新辅助治疗#中起作用,事实上,在化疗的新辅助治疗或治疗中,同样有作用,也不仅仅是#结直肠癌#,在#胃癌##肺癌#也可能起重要的作用。二甲双胍可以作为癌症的重要的辅助治疗措施

    0

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