Lancet Diabetes Endo:青少年肥胖与肿瘤风险

2020-02-04 MedSci MedSci原创

青少年肥胖导致肿瘤风险增加,并导致肿瘤死亡率增加

肥胖已被确定与多种癌症风险相关,近日研究人员考察了17岁时体重指数(BMI)与癌症发病率和死亡率之间的关系。

研究考察了1967-2010年间青少年体检时相关资料。研究的主要终点为任何肿瘤发病,次要终点为后继肿瘤死亡。

总计2298130名参与者,其中女性928110名女性。男性参与者随访29542735个随访年,发生26353例肿瘤。女性随访18044863个随访年,发生29488例肿瘤。肿瘤事件与BMI增加相关,青春期肥胖男性的肿瘤风险为1.26。女性中,未发生BMI增加与肿瘤总事件的相关性,且肥胖与宫颈癌和乳腺癌呈负相关,排除宫颈癌和乳腺癌后,BMI增加导致青春期女性肿瘤风险为1.27。BMI在85%以上人群10年后肿瘤风险增加。BMI增加导致肿瘤死亡率增加,高BMI占男性可归因于风险的5.1%,占女性的5.7%。

青少年肥胖导致肿瘤风险增加,并导致肿瘤死亡率增加。

原始出处:


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    2020-02-14 howi
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