Cardiovasc Diabetol:HbA1c水平有助于预测重症监护室患者的死亡风险

2022-06-05 MedSci原创 MedSci原创

HbA1c 水平≥5.7g%(糖尿病前期和糖尿病)与 ICCU 患者更差的预后相关

2型糖尿病(DM)是心血管疾病的已知危险因素,与非糖尿病患者相比,合并心血管疾病的 DM 患者的发病率和死亡率更高。血红蛋白 A1C (HbA1c) 是一种糖化血红蛋白,用于评估糖尿病患者的血糖控制情况。目前关于 HbA1c 水平在当下重症监护室(ICCU)患者中的预后意义的数据有限。

本研究旨在探索 HbA1c 水平对 ICCU 患者预后的预测意义。

该研究纳入了于2020年1月1日至2021年6月30日期间在三级医疗中心 ICCU 接受诊治、且有 HbA1c 水平数据的患者。根据 HbA1c 水平将患者分成三组:<5.7g%(无糖尿病),5.7-6.4g%(糖尿病前期)和≥6.5g%(DM)。


根据 HbA1c 水平分组患者的存活率

共纳入了1412位患者,其中974位(69%)是男性,平均67岁。HbA1c<5.7g%、5.7-6.4g%和≥6.5g%的患者分别有550位(39%)、458位(32.4%)和404位(28.6%)。在不知道自己有糖尿病的患者中,有81位(9.3%)在入院时有高 HbA1c 水平(≥6.5g%)。在长达1.5年的随访过程中,糖尿病前期和糖尿病患者的粗死亡率几乎是非糖尿病患者的两倍(10.6% vs 5.4%,p=0.01)。有趣的是,虽然没有统计学意义,但趋势是糖尿病前期患者与死亡率的相关性最强(HR 1.83, p=0.077)。

总而言之,虽然 HbA1c 水平≥5.7g%(糖尿病前期和糖尿病)与 ICCU 患者更差的预后相关,但矛盾的是,糖尿病前期患者的死亡风险(无论是短期还是长期风险)最高

 

原始出处:

Lupu, L., Taha, L., Farkash, R. et al. Hemoglobin A1C as a prognostic factor and the pre-diabetic paradox in patients admitted to a tertiary care medical center intensive cardiac care unit. Cardiovasc Diabetol 21, 86 (2022). https://doi.org/10.1186/s12933-022-01529-1

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    2023-05-19 docwu2019
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    2023-02-26 quxin068
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    2022-07-01 Smile2680
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    2022-06-06 bioon6
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    2022-06-06 学医无涯

    学习一下

    0

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