Sci Rep:代谢不健康状态患者的膀胱癌发病率增加

2020-04-29 AlexYang MedSci原创

最近,有研究人员评估了代谢健康状态和膀胱癌发生率之间的相关性,数据来自韩国国家健康保险系统和国家健康检查(NHC)数据库的代表性数据。

最近,有研究人员评估了代谢健康状态和膀胱癌发生率之间的相关性,数据来自韩国国家健康保险系统和国家健康检查(NHC)数据库的代表性数据。

研究人员分析了2009年到2012年参与NHC的11781768名男性的数据。正常体重和身体肥胖分类根据身体质量指数(BMI)<25和≥25kg/m2来进行。代谢肥胖定义为存在≥3种的代谢综合征成分。研究人员将参与者分成代谢健康,正常体重(MHNW);代谢肥胖,正常体重(MONW);代谢健康,肥胖(MHO);和代谢肥胖,肥胖(MOO)。多变量调整后Cox回归分析调查了代谢健康状态与膀胱癌发生率的关系。研究也包括了新鉴定为膀胱癌的17777名男性。根据代谢健康状态分类的分析阐释了MOO和MONW组比MHO组具有更高的多变量调整后风险比(1.307 [95% CI: 1.258-1.358], 1.183 [95% CI: 1.137-1.231]和1.066 [95% CI: 1.017-1.119;相对于MHNW风险比)。

最后,研究人员指出,他们发现了代谢健康状态与膀胱癌发生率之间的相关性,并且代谢健康状态成分增加,风险也随之增加。

原始出处:

Jong Wook Kim, Sun Tae Ahn, Mi Mi Oh et al. Increased incidence of bladder cancer with metabolically unhealthy status: analysis from the National Health Checkup database in Korea. Sci Rep. 15 April 2020

 

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    2020-06-07 lifestar
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    2020-04-29 留走人康

    膀胱癌真怪,明明是免疫敏感性肿瘤,为什么PD-1治疗效果不好呢?难道靶点不对?将来CD47会不会有效

    0

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