Int J Clin Oncol:4天MEA治疗绒癌和高危GTN的疗效

2020-06-28 网络 网络

本研究旨在评估4天化疗与甲氨蝶呤、依托泊苷和放线菌素D(MEA)对诊断为绒癌和高危妊娠滋养细胞瘤(GTN)患者的疗效和毒性。

本研究旨在评估4天化疗与甲氨蝶呤、依托泊苷和放线菌素D(MEA)对诊断为绒癌和高危妊娠滋养细胞瘤(GTN)患者的疗效和毒性。

 

1999年1月至2015年12月期间,29名患者在被诊断为绒癌或高危GTN后接受了4天MEA治疗。对4天MEA的完全缓解和不良反应进行了回顾性评估。

 

结果,所有患者和接受4天MEA作为一线治疗的患者的完全缓解率分别为79.3%(23/29)和87.5%(21/24)。在6名对4天MEA产生耐药的患者中,有3名患者通过其他治疗出现完全缓解,另外3名患者因病死亡。主要不良反应为白细胞减少、贫血和恶心。在23例用4天MEA治愈的患者中,有14例患者因白细胞减少、肝毒性和口腔炎而改用依托泊苷和放线菌素D(EA)方案治疗。在20例需要激素治疗的患者中,15例患者治疗后月经周期正常。5例患者共受孕9次(7例足月活产,2例自然流产)。没有早产或出生体重过低的婴儿,也没有先天性畸形。

 

总之,该研究结果表明,4天MEA治疗绒癌和高危GTN的疗效和不良反应可能与EMA/CO处于同一水平。但如何确定将4天MEA治疗方案改为EA方案的标准,还需进一步研究。

 

原始出处:

 

Shizuka Sato, Eiko Yamamoto, et al., The Efficacy and Toxicity of 4-day Chemotherapy With Methotrexate, Etoposide and Actinomycin D in Patients With Choriocarcinoma and High-Risk Gestational Trophoblastic Neoplasia. Int J Clin Oncol. 2020 Jan;25(1):203-209. doi: 10.1007/s10147-019-01540-9.  

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    2021-04-30 MedSciZeng

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  2. [GetPortalCommentsPageByObjectIdResponse(id=961851, encodeId=d251961851a5, content=<a href='/topic/show?id=11cf104251a3' target=_blank style='color:#2F92EE;'>#J Clin Oncol#</a>点击查看更多该期刊内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104251, encryptionId=11cf104251a3, topicName=J Clin Oncol)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Fri Apr 30 17:17:28 CST 2021, time=2021-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1865860, encodeId=5f171865860cb, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sun Dec 06 20:20:22 CST 2020, time=2020-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032557, encodeId=3272103255e66, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Sun Jun 28 19:20:22 CST 2020, time=2020-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038061, encodeId=dd7e10380610e, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Sun Jun 28 19:20:22 CST 2020, time=2020-06-28, status=1, ipAttribution=)]
    2020-12-06 minlingfeng
  3. [GetPortalCommentsPageByObjectIdResponse(id=961851, encodeId=d251961851a5, content=<a href='/topic/show?id=11cf104251a3' target=_blank style='color:#2F92EE;'>#J Clin Oncol#</a>点击查看更多该期刊内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104251, encryptionId=11cf104251a3, topicName=J Clin Oncol)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Fri Apr 30 17:17:28 CST 2021, time=2021-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1865860, encodeId=5f171865860cb, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sun Dec 06 20:20:22 CST 2020, time=2020-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032557, encodeId=3272103255e66, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Sun Jun 28 19:20:22 CST 2020, time=2020-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038061, encodeId=dd7e10380610e, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Sun Jun 28 19:20:22 CST 2020, time=2020-06-28, status=1, ipAttribution=)]
    2020-06-28 内科新手

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  4. [GetPortalCommentsPageByObjectIdResponse(id=961851, encodeId=d251961851a5, content=<a href='/topic/show?id=11cf104251a3' target=_blank style='color:#2F92EE;'>#J Clin Oncol#</a>点击查看更多该期刊内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104251, encryptionId=11cf104251a3, topicName=J Clin Oncol)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Fri Apr 30 17:17:28 CST 2021, time=2021-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1865860, encodeId=5f171865860cb, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sun Dec 06 20:20:22 CST 2020, time=2020-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032557, encodeId=3272103255e66, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Sun Jun 28 19:20:22 CST 2020, time=2020-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038061, encodeId=dd7e10380610e, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Sun Jun 28 19:20:22 CST 2020, time=2020-06-28, status=1, ipAttribution=)]
    2020-06-28 anti-cancer

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