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Am J Gastroenterol：胃肠上皮化生和不典型增生患者胃腺癌的危险因素及预测

2016-05-23 Seven L MedSci原创

胃肠上皮化生不典型增生胃腺癌
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胃肠上皮化生和不典型增生为腺癌癌前病变，但是目前仍缺乏这些癌前病变患者发展为胃腺癌的风险和预测的相关研究。研究者在2006-2006年之间，纳入了于加州北部凯萨医疗机构诊断为胃粘膜肠上皮化生或不典型增生的4331名患者，随访至2013年，记录患者的胃腺癌发生率，与一般人群比较评估相对风险，并探究与发展为恶性肿瘤相关的预测因素。在24440人年的随访时间里，在4146名胃粘膜肠上皮化生和141名低分

胃肠上皮化生和不典型增生为腺癌癌前病变，但是目前仍缺乏这些癌前病变患者发展为胃腺癌的风险和预测的相关研究。

研究者在2006-2006年之间，纳入了于加州北部凯萨医疗机构诊断为胃粘膜肠上皮化生或不典型增生的4331名患者，随访至2013年，记录患者的胃腺癌发生率，与一般人群比较评估相对风险，并探究与发展为恶性肿瘤相关的预测因素。

在24440人年的随访时间里，在4146名胃粘膜肠上皮化生和141名低分化不典型增生的患者中，分别有17和6名患者在内镜检查后1年内发展为胃腺癌，发生率分别为0.72/1000人年和7.7/1000人年，与一般人群比较，相对风险分别为2.56 (95% CI 1.49-4.10) 和25.6 (95% CI, 9.4-55.7)，发展为胃腺癌的中位数间隔时间分别为6.1年和2.6年。西班牙裔/种族和不典型增生是进展为胃腺癌的高危因素。

研究结果表明，胃黏膜上皮化生和不典型增生是胃腺癌的重要预测因子。其中肠上皮化生发展为恶性肿瘤为低风险，因此不需要日常内镜检查；而具有可疑内镜表现、存在不典型增生和西班牙裔/种族等高风险患者，应该考虑日常内镜监测。

原始出处：

Li D, Bautista MC,et al.Risks and Predictors of Gastric Adenocarcinoma in Patients with Gastric Intestinal Metaplasia and Dysplasia: A Population-Based Study.Am J Gastroenterol. 2016 May 17. doi: 10.1038/ajg.2016.188. [Epub ahead of print]

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    2016-10-30 jktdtl

    #Gastroenterol#

    0

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    2017-02-26 zhishijing

    #不典型增生#

    0

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    2017-04-21 许安

    #GAS#

    0

  4. 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objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81520, encryptionId=d9ed815204f, topicName=肠上皮化生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c32257, createdName=DEXTER3139, createdTime=Wed Mar 01 13:04:00 CST 2017, time=2017-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138112, encodeId=ade9138112af, content=拜读，好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 30 15:14:24 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1898623, encodeId=cae1189862366, content=<a href='/topic/show?id=e5062028978' target=_blank style='color:#2F92EE;'>#不典型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20289, encryptionId=e5062028978, topicName=不典型)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sun Sep 25 01:04:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305919, encodeId=078d130591914, content=<a href='/topic/show?id=4f25833660c' target=_blank style='color:#2F92EE;'>#胃腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83366, encryptionId=4f25833660c, topicName=胃腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6595338, createdName=xuruicheng, createdTime=Wed May 25 13:04:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86910, encodeId=92008691089, content=(^_^)要重视噢(#?Д?)π_π, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/56E251DADB00C0E09DFFE92062DA5CA9/100, createdBy=e64d1728092, createdName=QQda5e99cf, createdTime=Tue May 24 08:58:00 CST 2016, time=2016-05-24, status=1, ipAttribution=)]
    2017-03-03 ms24272190615788285182

    #AST#

    0

  5. 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content=<a href='/topic/show?id=e5062028978' target=_blank style='color:#2F92EE;'>#不典型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20289, encryptionId=e5062028978, topicName=不典型)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sun Sep 25 01:04:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305919, encodeId=078d130591914, content=<a href='/topic/show?id=4f25833660c' target=_blank style='color:#2F92EE;'>#胃腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83366, encryptionId=4f25833660c, topicName=胃腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6595338, createdName=xuruicheng, createdTime=Wed May 25 13:04:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86910, encodeId=92008691089, content=(^_^)要重视噢(#?Д?)π_π, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/56E251DADB00C0E09DFFE92062DA5CA9/100, createdBy=e64d1728092, createdName=QQda5e99cf, createdTime=Tue May 24 08:58:00 CST 2016, time=2016-05-24, status=1, ipAttribution=)]
    2016-11-16 zxl739

    #胃肠上皮化生#

    0

  6. 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content=<a href='/topic/show?id=e5062028978' target=_blank style='color:#2F92EE;'>#不典型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20289, encryptionId=e5062028978, topicName=不典型)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sun Sep 25 01:04:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305919, encodeId=078d130591914, content=<a href='/topic/show?id=4f25833660c' target=_blank style='color:#2F92EE;'>#胃腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83366, encryptionId=4f25833660c, topicName=胃腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6595338, createdName=xuruicheng, createdTime=Wed May 25 13:04:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86910, encodeId=92008691089, content=(^_^)要重视噢(#?Д?)π_π, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/56E251DADB00C0E09DFFE92062DA5CA9/100, createdBy=e64d1728092, createdName=QQda5e99cf, createdTime=Tue May 24 08:58:00 CST 2016, time=2016-05-24, status=1, ipAttribution=)]
    2017-03-01 DEXTER3139

    #肠上皮化生#

    0

  7. 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encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Fri Mar 03 09:04:00 CST 2017, time=2017-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1705608, encodeId=24921e05608bd, content=<a href='/topic/show?id=0f638326609' target=_blank style='color:#2F92EE;'>#胃肠上皮化生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83266, encryptionId=0f638326609, topicName=胃肠上皮化生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=802f30999513, createdName=zxl739, createdTime=Wed Nov 16 12:04:00 CST 2016, time=2016-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1969112, encodeId=ca64196911213, content=<a href='/topic/show?id=d9ed815204f' target=_blank style='color:#2F92EE;'>#肠上皮化生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81520, encryptionId=d9ed815204f, topicName=肠上皮化生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c32257, createdName=DEXTER3139, createdTime=Wed Mar 01 13:04:00 CST 2017, time=2017-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138112, encodeId=ade9138112af, content=拜读，好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 30 15:14:24 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1898623, encodeId=cae1189862366, content=<a href='/topic/show?id=e5062028978' target=_blank style='color:#2F92EE;'>#不典型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20289, encryptionId=e5062028978, topicName=不典型)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sun Sep 25 01:04:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305919, encodeId=078d130591914, content=<a href='/topic/show?id=4f25833660c' target=_blank style='color:#2F92EE;'>#胃腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83366, encryptionId=4f25833660c, topicName=胃腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6595338, createdName=xuruicheng, createdTime=Wed May 25 13:04:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86910, encodeId=92008691089, content=(^_^)要重视噢(#?Д?)π_π, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/56E251DADB00C0E09DFFE92062DA5CA9/100, createdBy=e64d1728092, createdName=QQda5e99cf, createdTime=Tue May 24 08:58:00 CST 2016, time=2016-05-24, status=1, ipAttribution=)]
    2016-09-30 1e10c84am36(暂无匿称)

    拜读，好文

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2063974, encodeId=945e20639e49d, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Sun Oct 30 10:04:00 CST 2016, time=2016-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1970310, encodeId=c47e19e03102c, content=<a href='/topic/show?id=bc8d202929a' target=_blank style='color:#2F92EE;'>#不典型增生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20292, encryptionId=bc8d202929a, topicName=不典型增生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Sun Feb 26 12:04:00 CST 2017, time=2017-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071638, encodeId=1e9620e16380b, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Apr 21 14:04:00 CST 2017, time=2017-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710873, encodeId=9ffb1e1087336, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Fri Mar 03 09:04:00 CST 2017, time=2017-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1705608, encodeId=24921e05608bd, content=<a href='/topic/show?id=0f638326609' target=_blank style='color:#2F92EE;'>#胃肠上皮化生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83266, encryptionId=0f638326609, topicName=胃肠上皮化生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=802f30999513, createdName=zxl739, createdTime=Wed Nov 16 12:04:00 CST 2016, time=2016-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1969112, encodeId=ca64196911213, content=<a href='/topic/show?id=d9ed815204f' target=_blank style='color:#2F92EE;'>#肠上皮化生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81520, encryptionId=d9ed815204f, topicName=肠上皮化生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c32257, createdName=DEXTER3139, createdTime=Wed Mar 01 13:04:00 CST 2017, time=2017-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138112, encodeId=ade9138112af, content=拜读，好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 30 15:14:24 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1898623, encodeId=cae1189862366, content=<a href='/topic/show?id=e5062028978' target=_blank style='color:#2F92EE;'>#不典型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20289, encryptionId=e5062028978, topicName=不典型)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sun Sep 25 01:04:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305919, encodeId=078d130591914, content=<a href='/topic/show?id=4f25833660c' target=_blank style='color:#2F92EE;'>#胃腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83366, encryptionId=4f25833660c, topicName=胃腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6595338, createdName=xuruicheng, createdTime=Wed May 25 13:04:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86910, encodeId=92008691089, content=(^_^)要重视噢(#?Д?)π_π, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/56E251DADB00C0E09DFFE92062DA5CA9/100, createdBy=e64d1728092, createdName=QQda5e99cf, createdTime=Tue May 24 08:58:00 CST 2016, time=2016-05-24, status=1, ipAttribution=)]
    2016-09-25 yaanren

    #不典型#

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2063974, encodeId=945e20639e49d, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Sun Oct 30 10:04:00 CST 2016, time=2016-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1970310, encodeId=c47e19e03102c, content=<a href='/topic/show?id=bc8d202929a' target=_blank style='color:#2F92EE;'>#不典型增生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20292, encryptionId=bc8d202929a, topicName=不典型增生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Sun Feb 26 12:04:00 CST 2017, time=2017-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071638, encodeId=1e9620e16380b, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Apr 21 14:04:00 CST 2017, time=2017-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710873, encodeId=9ffb1e1087336, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Fri Mar 03 09:04:00 CST 2017, time=2017-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1705608, encodeId=24921e05608bd, content=<a href='/topic/show?id=0f638326609' target=_blank style='color:#2F92EE;'>#胃肠上皮化生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83266, encryptionId=0f638326609, topicName=胃肠上皮化生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=802f30999513, createdName=zxl739, createdTime=Wed Nov 16 12:04:00 CST 2016, time=2016-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1969112, encodeId=ca64196911213, content=<a href='/topic/show?id=d9ed815204f' target=_blank style='color:#2F92EE;'>#肠上皮化生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81520, encryptionId=d9ed815204f, topicName=肠上皮化生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c32257, createdName=DEXTER3139, createdTime=Wed Mar 01 13:04:00 CST 2017, time=2017-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138112, encodeId=ade9138112af, content=拜读，好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 30 15:14:24 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1898623, encodeId=cae1189862366, content=<a href='/topic/show?id=e5062028978' target=_blank style='color:#2F92EE;'>#不典型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20289, encryptionId=e5062028978, topicName=不典型)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sun Sep 25 01:04:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305919, encodeId=078d130591914, content=<a href='/topic/show?id=4f25833660c' target=_blank style='color:#2F92EE;'>#胃腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83366, encryptionId=4f25833660c, topicName=胃腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6595338, createdName=xuruicheng, createdTime=Wed May 25 13:04:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86910, encodeId=92008691089, content=(^_^)要重视噢(#?Д?)π_π, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/56E251DADB00C0E09DFFE92062DA5CA9/100, createdBy=e64d1728092, createdName=QQda5e99cf, createdTime=Tue May 24 08:58:00 CST 2016, time=2016-05-24, status=1, ipAttribution=)]
    2016-05-25 xuruicheng

    #胃腺癌#

    0

  10. 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createdBy=5d70341, createdName=zhishijing, createdTime=Sun Feb 26 12:04:00 CST 2017, time=2017-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071638, encodeId=1e9620e16380b, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Apr 21 14:04:00 CST 2017, time=2017-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710873, encodeId=9ffb1e1087336, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Fri Mar 03 09:04:00 CST 2017, time=2017-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1705608, encodeId=24921e05608bd, content=<a href='/topic/show?id=0f638326609' target=_blank style='color:#2F92EE;'>#胃肠上皮化生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83266, encryptionId=0f638326609, topicName=胃肠上皮化生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=802f30999513, createdName=zxl739, createdTime=Wed Nov 16 12:04:00 CST 2016, time=2016-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1969112, encodeId=ca64196911213, content=<a href='/topic/show?id=d9ed815204f' target=_blank style='color:#2F92EE;'>#肠上皮化生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81520, encryptionId=d9ed815204f, topicName=肠上皮化生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c32257, createdName=DEXTER3139, createdTime=Wed Mar 01 13:04:00 CST 2017, time=2017-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138112, encodeId=ade9138112af, content=拜读，好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 30 15:14:24 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1898623, encodeId=cae1189862366, content=<a href='/topic/show?id=e5062028978' target=_blank style='color:#2F92EE;'>#不典型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20289, encryptionId=e5062028978, topicName=不典型)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sun Sep 25 01:04:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305919, encodeId=078d130591914, content=<a href='/topic/show?id=4f25833660c' target=_blank style='color:#2F92EE;'>#胃腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83366, encryptionId=4f25833660c, topicName=胃腺癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6595338, createdName=xuruicheng, createdTime=Wed May 25 13:04:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86910, encodeId=92008691089, content=(^_^)要重视噢(#?Д?)π_π, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/56E251DADB00C0E09DFFE92062DA5CA9/100, createdBy=e64d1728092, createdName=QQda5e99cf, createdTime=Tue May 24 08:58:00 CST 2016, time=2016-05-24, status=1, ipAttribution=)]
    2016-05-24 QQda5e99cf

    (^_^)要重视噢(#?Д?)π_π

    0

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