J Dermatolog Treat:布达鲁单抗可有效治疗头皮/指甲银屑病

2022-02-21 MedSci原创 MedSci原创

据估计,近 80% 的银屑病患者会出现头皮受累的情况。此外,银屑病也可影响指甲,包括甲板、甲基质、甲床和其他上皮组织,约有一半的银屑病患者有指甲受累。

据估计,近 80% 的银屑病患者会出现头皮受累的情况。此外,银屑病也可影响指甲,包括甲板、甲基质、甲床和其他上皮组织,约有一半的银屑病患者有指甲受累。Brodalumab(布达鲁单抗)是一种全人类抗白细胞介素-17受体A(IL-17RA)的单克隆抗体,可拮抗炎症细胞因子的功能,被批准用于治疗对其他系统疗法疗效不好的成人银屑病患者。近日,发表于J Dermatolog Treat的三项3期研究(AMAGINE-1/-2/-3)中研究人员评估了布达鲁单抗对指甲或头皮银屑病患者的疗效。

在AMAGINE-1中,患者接受布达鲁单抗 210 mg每2周(Q2W)或安慰剂至12周,报告通过银屑病头皮严重程度指数(PSSI)测量的头皮清除率。在AMAGINE-2/3中,患者接受布达鲁单抗 210 mg Q2W或乌司奴单抗连续治疗52周,报告由指甲银屑病严重程度指数(NAPSI)衡量的指甲清除率。

 

结果显示,在第12周,与安慰剂相比,更多接受布达鲁单抗的患者从基线PSSI达到75%和100%的改善率,并且在12周内平均PSSI较低。在第2周,与安慰剂相比,布达鲁单抗 210 mg Q2W 组患者PSSI有明显改善。在52周内,与接受乌司奴单抗的患者相比,接受布达鲁单抗的患者指甲银屑病的完全清除率(NAPSI 0)明显更高,平均NAPSI更低,比基线NAPSI的平均改善率更高。在第52周,63.8%接受布达鲁单抗的患者实现了NAPSI 0,而接受乌司奴单抗的患者为39.1%。

综上所述,该研究结果表明,布达鲁单抗的使用与头皮银屑病的清除有关,效果可达12周,而指甲银屑病的改善(包括指甲完全清除),效果可达52周。

出处:

Boni Elewski, et al., Efficacy of brodalumab in the treatment of scalp and nail psoriasis: results from three phase 3 trials. J Dermatolog Treat. 2022 Feb;33(1):261-265. doi: 10.1080/09546634.2020.1749546.  

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    2022-10-03 ycmayy
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    2022-02-22 ms2000001545439177

    受益匪浅

    0

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    2022-02-21 zlk-wbh

    学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1678418, encodeId=ba5016e841833, content=<a href='/topic/show?id=a6f85642ebd' target=_blank style='color:#2F92EE;'>#指甲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56427, encryptionId=a6f85642ebd, topicName=指甲)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3ee927698160, createdName=ycmayy, createdTime=Mon Oct 03 04:35:50 CST 2022, time=2022-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796298, encodeId=b73f1e9629885, content=<a href='/topic/show?id=cf2a1e7818c' target=_blank style='color:#2F92EE;'>#TREAT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17781, encryptionId=cf2a1e7818c, topicName=TREAT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=606c2500035, createdName=ms3153534357578991, createdTime=Sun Jan 22 09:35:50 CST 2023, time=2023-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1196137, encodeId=4793119613ec2, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ede65630636, createdName=ms2000001545439177, createdTime=Tue Feb 22 16:40:23 CST 2022, time=2022-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619634, encodeId=5dcb1619634a1, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Tue Feb 22 08:35:50 CST 2022, time=2022-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1195891, encodeId=bd9c1195891ca, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7835166989, createdName=zlk-wbh, createdTime=Mon Feb 21 22:54:11 CST 2022, time=2022-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1195787, encodeId=d8c21195e8744, content=谢谢分享,值得一读。, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Mon Feb 21 18:59:43 CST 2022, time=2022-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1195716, encodeId=a76f1195e16ad, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ac976513572, createdName=ms9000000245242422, createdTime=Mon Feb 21 15:41:41 CST 2022, time=2022-02-21, status=1, ipAttribution=)]
    2022-02-21 yangchou

    谢谢分享,值得一读。

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1678418, encodeId=ba5016e841833, content=<a href='/topic/show?id=a6f85642ebd' target=_blank style='color:#2F92EE;'>#指甲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56427, encryptionId=a6f85642ebd, topicName=指甲)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3ee927698160, createdName=ycmayy, createdTime=Mon Oct 03 04:35:50 CST 2022, time=2022-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796298, encodeId=b73f1e9629885, content=<a href='/topic/show?id=cf2a1e7818c' target=_blank style='color:#2F92EE;'>#TREAT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17781, encryptionId=cf2a1e7818c, topicName=TREAT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=606c2500035, createdName=ms3153534357578991, createdTime=Sun Jan 22 09:35:50 CST 2023, time=2023-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1196137, encodeId=4793119613ec2, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ede65630636, createdName=ms2000001545439177, createdTime=Tue Feb 22 16:40:23 CST 2022, time=2022-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619634, encodeId=5dcb1619634a1, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Tue Feb 22 08:35:50 CST 2022, time=2022-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1195891, encodeId=bd9c1195891ca, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7835166989, createdName=zlk-wbh, createdTime=Mon Feb 21 22:54:11 CST 2022, time=2022-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1195787, encodeId=d8c21195e8744, content=谢谢分享,值得一读。, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Mon Feb 21 18:59:43 CST 2022, time=2022-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1195716, encodeId=a76f1195e16ad, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ac976513572, createdName=ms9000000245242422, createdTime=Mon Feb 21 15:41:41 CST 2022, time=2022-02-21, status=1, ipAttribution=)]
    2022-02-21 ms9000000245242422

    很好

    0

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