Neurobiology of Aging:研究发现肥胖的新害处:损伤大脑、增加痴呆风险

2021-07-30 “生物世界”公众号 “生物世界”公众号

在当今社会,随着经济发展和生活水平的提高,在全世界范围内,肥胖已经成为了一个主要公共健康问题。据世界卫生组织(WHO)统计,全球有近20亿人超重或肥胖,从1975到2016年,全球肥胖率翻了近3倍,每

在当今社会,随着经济发展和生活水平的提高,在全世界范围内,肥胖已经成为了一个主要公共健康问题。据世界卫生组织(WHO)统计,全球有近20亿人超重或肥胖,从1975到2016年,全球肥胖率翻了近3倍,每年因超重或肥胖导致的死亡高达280万。

实际上,肥胖既是一种特征,也是一种疾病,肥胖的人不仅生活不便、运动能力下降,还更易患代谢性疾病和心脑血管疾病,此外,许多研究表明,肥胖与十多种癌症的发病风险增加和预后及生存率降低有关。

灰质是大脑的重要组成部分,负责执行控制、肌肉和感官活动以及学习、注意力和记忆。

近日,南澳大利亚大学的研究人员在 Neurobiology of Aging 期刊发表了题为:Unlocking the causal link of metabolically different adiposity subtypes with brain volumes and the risks of dementia and stroke: A Mendelian randomization study 的研究论文。

该研究使用孟德尔随机化方法检查了英国生物银行(UK Biobank)中多达 336000 条个人记录的遗传数据,其中包含自我报告的信息以及关联的医院和死亡登记信息。发现身体质量指数(BMI)每增加 1 kg/m2(相当于平均身高173cm的人增重3Kg),中老年人(37-73岁)的大脑灰质就减少0.3%。

这表明肥胖与大脑灰质萎缩有关,提醒了我们肥胖的新害处:损害大脑健康,增加痴呆症风险。这也表明改善代谢相关肥胖有助于大脑健康。

论文作者将肥胖分为三种亚型,分别是代谢不利肥胖(BMI和腰臀比同时增加)、代谢中性肥胖(仅BMI增加)、代谢有利肥胖(BMI增加、腰臀比下降)。

这三种代谢不同的肥胖亚型都具有较高的身体质量指数(BMI),但每种亚型的体脂和内脏脂肪分布各不相同,因此患心脏代谢疾病的风险也不同。

然后,研究团队使用孟德尔随机化方法检查了英国生物银行(UK Biobank)中多达 336000 条个人记录的遗传数据,其中包含自我报告的信息以及关联的医院和死亡登记信息。发现肥胖程度较高的人,尤其是那些代谢不利肥胖(BMI和腰臀比同时增加)和代谢中性肥胖(仅BMI增加)的人,其大脑灰质体积水平更低。

具体来说,身体质量指数(BMI)每增加 1 kg/m2(相当于平均身高173cm的人增重3Kg),中老年人(37-73岁)的大脑灰质就减少0.3%。这表明这些人可能已经损害了大脑功能。

这表明肥胖与大脑灰质萎缩有关,提醒了我们肥胖的新害处:损害大脑健康,增加痴呆症风险。这也表明改善代谢相关肥胖有助于大脑健康。

原始出处:

Anwar Mulugeta, et al. Unlocking the causal link of metabolically different adiposity subtypes with brain volumes and the risks of dementia and stroke: A Mendelian randomization study. Neurobiology of Aging, Volume 102, June 2021, Pages 161-169.

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    2022-02-08 sunylz
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    2021-07-27 junJUN

    老年人痴呆何药可用??

    0

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