Sci Rep:前列腺切除术后尿失禁的新型治疗方法:富含血小板血浆尿道括约肌注射

2021-03-20 AlexYang MedSci原创

富含血小板的血浆(PRP)是再生医学中最具创新性的血源性产品。

富含血小板的血浆(PRP)是再生医学中最具创新性的血源性产品。

最近,有研究人员调查了PRP尿道括约肌注射治疗前列腺切除术后尿失禁(PPI)的效果

研究人员前瞻性地招募了28名PPI患者,平均年龄为71.8±8.9岁。他们每月接受4次PRP尿道括约肌注射。第4次注射后3个月,进行治疗后全身反应评估(GRA)评分、新设计的压力性尿失禁视觉模拟量表(VAS of SUI)和尿动力学参数。注射后GRA四分位数的中位数为2.0(1.0,2.0)。总的来说,6名(21.4%)患者达到完全自制和无垫状态,20名(71.4%)患者达到成功的治疗结果(GRA评分≥2分),26名(92.9%)患者表现出临床改善(GRA评分≥1分)。SUI的VAS从6.5(5.0,8.0)明显改善到3.5(2.0-5.8)(P<0.001);腹腔漏点压力从57.5(50.0,115.0)提高到126.0(68.3,150.0)(P=0.004)。反复注射PRP尿道括约肌后,SUI严重程度明显减轻,且成功率高。除3例患者出现轻度血尿和排尿痛外,无重大不良事件发生。

最后,研究人员指出,PRP尿道括约肌注射是PPI的一种新型治疗方法,并且安全有效

原始出处:

Ping-Jui Lee, Yuan-Hong Jiang,Hann-Chorng Kuo. A novel management for postprostatectomy urinary incontinence: platelet-rich plasma urethral sphincter injection. Sci Rep. Mar 2021

 

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    2021-11-19 午夜星河

    受教

    0

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    2021-05-24 lifestar
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