AAN发布特发性震颤指南(附下载)

2011-12-02 MedSci原创 MedSci原创

 美国神经病学学会近日发布了特发性震颤最佳疗法的最新指南,该指南于2011年10月19日在线发表于美国神经病学会医学杂志《Neurology》上。指南还被国际特发性震颤基金会(the International Essential Tremor Foundation)认可。 特发性震颤(Essential tremor,ET)是震颤障碍最常见的类型,通常易与其他运动障碍(如帕金森病

 美国神经病学学会近日发布了特发性震颤最佳疗法的最新指南,该指南于2011年10月19日在线发表于美国神经病学会医学杂志《Neurology》上。指南还被国际特发性震颤基金会(the International Essential Tremor Foundation)认可。


特发性震颤(Essential tremor,ET)是震颤障碍最常见的类型,通常易与其他运动障碍(如帕金森病)混淆。特发性震颤累及手,头部,声音,在美国,预计有1000万因该障碍而致残的患者。尽管其症状可以在任何年龄阶段出现,并可能引起日常活动困难,如吃饭,写字,缝纫或剃须,但特发性震颤通常发病于40岁后。

指南中提出,以前被用来治疗癫痫发作的高血压药物普萘洛尔和扑米酮在改善特发性震颤患者发抖方面最有效。指南同样发现癫痫药加巴喷丁和托吡酯联合高血压药阿替洛尔和索他洛尔以及焦虑药物阿普唑仑可发挥作用。

“由于并不是所有的特发性震颤患者都能从这些药物中受益,因此有必要进行更多且更好的研究。”指南的主要作者南福罗里达州美国神经病学院成员Theresa A. Zesiewicz博士表示。“对于不能从这些药物中受益的患者,其与神经病学家一起研究出其他的治疗方法很重要。”

该指南发现了两种类型的脑手术:深部脑刺激法和丘脑切开术,其对治疗那些不能从药物治疗中获益的特发性震颤患者可能有用。

另外,并无充分的证据显示高血压药纳多洛尔和尼莫地平以及癫痫药药物氯硝西泮和A型肉毒毒素可能对治疗特发性震颤患者有用。

此版更新的指南与学会2005版指南的不同之处在于前者没有推荐用癫痫药物左乙拉西坦和氟桂利嗪或者3,4 - 二氨基吡啶(用于罕见的肌肉疾病)治疗胳膊和腿的震颤。该指南还发现尚没有足够证据支持使用治疗精神分裂症的药物氯氮平对特发性震颤患者有用。


相关介绍

美国神经病学学会(The American Academy of Neurology)是一个由24,000多名神经病学家和神经科学专家组成的协会,它致力于推动最高质量、以病人为中心的神经病的治疗。每名神经病学家均是在脑以及神经系统疾病的诊断、治疗和处理方面经过专业培训的医生,如阿尔茨海默病、卒中、偏头痛、多发性硬化、脑损伤、帕金森病和癫痫。


免费指南全文:AAN最新特发性震颤指南.pdf

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    2011-12-03 bluefate123
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    2011-12-03 kalseyzl