JCEM:儿童毛发皮质醇浓度与脂肪的关系

2020-11-01 MedSci原创 MedSci原创

6岁时较高的HCC与10岁时BMI、FMI、肝脂肪分数升高以及较高的超重和NAFLD风险有关,仅肝脂肪分数和NAFLD的关联独立于6岁时FMI。

从童年开始,压力可能会导致不良的体脂分布。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在评估6岁时头发皮质醇浓度(HCC)与10岁时一般和器官脂肪指标、超重和非酒精性脂肪肝疾病(NAFLD)风险之间的关联,并评估这种关联独立于6岁时肥胖指标。

研究人员测量了6岁儿童(n=2042)头发中的HCC,该研究的主要结局指标为在10年时获得的BMI、通过DXA扫描测量的脂肪质量指数(FMI)以及通过MRI测量的内脏脂肪指数、心包脂肪指数、肝脂肪分数以及超重和NAFLD风险。

6岁时较高的HCC与10岁时较高的BMI、FMI和超重风险增加之间的关联可通过6岁时观察到的关联来解释。6岁时的HCC与10岁时较高的肝脏脂肪分数(肝脏脂肪分数标准差得分(SDS)差异为0.11(95%置信区间(CI)为0.03-0.18))和较高的NAFLD的风险相关(OR为1.95,95%CI为1.06-3.56),与6岁时的FMI无关,HCC与心包或内脏脂肪指数无关。

由此可见,6岁时较高的HCC与10岁时BMI、FMI、肝脂肪分数升高以及较高的超重和NAFLD风险有关,仅肝脂肪分数和NAFLD的关联独立于6岁时FMI。

原始出处:

Florianne O L Vehmeijer.et al.Associations of hair cortisol concentrations with general and organ fat measures in childhood.JCEM.2020.https://doi.org/10.1210/clinem/dgaa785

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    2021-09-16 smallant2015
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    2021-03-14 ms2000000239662574

    精神分裂症患者头发皮质醇水平和患者的症状,社会支持水平相关。

    0

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    2021-01-27 achengzhao
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