JAMA Network Open:大麻能够减轻镰状细胞病疼痛

2020-07-20 Allan MedSci原创

加州大学欧文分校研究员Kalpna Gupta和加州大学旧金山分校的Donald Abrams博士共同领导的一项临床试验表明,大麻似乎是治疗镰状细胞疾病慢性疼痛的一种有效疗法。

加州大学欧文分校研究员Kalpna Gupta和加州大学旧金山分校的Donald Abrams博士共同领导的一项临床试验表明,大麻似乎是治疗镰状细胞疾病慢性疼痛的一种有效疗法。

Kalpna Gupta说:“这些试验结果表明,汽化大麻总体上是安全的。建议镰状细胞病患者可以使用大麻减轻疼痛”。阿片类药物目前是治疗镰状细胞病引起的慢性和急性疼痛的主要疗法,但是与阿片类药物相关的死亡人数的上升促使医生降低了阿片类药物处方的使用频率。Kalpna Gupta补充说:“我们不知道所有形式的大麻产品是否会对慢性疼痛产生相似的影响。我们使用的汽化大麻可能比其他形式的大麻更安全”。

该双盲、安慰剂对照试验是首次评估大麻缓解镰状细胞病患者疼痛的潜力。该试验中使用的大麻是从美国国立卫生研究院的国家药物滥用研究所(National Institute of Drug Abuse)获得的,大麻中含有相同数量的四氢大麻酚。

 

原始出处:

https://www.firstwordpharma.com/node/1741679?tsid=4

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  1. [GetPortalCommentsPageByObjectIdResponse(id=914504, encodeId=543591450477, content=慢性疼痛是病, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210107/85c58416bc1443e3b8be867a2e84ebcd/b3508e8c26a9408cbe4bb865d6564b7b.jpg, createdBy=1f135450971, createdName=醉舞清风2, createdTime=Thu Jan 07 21:08:28 CST 2021, time=2021-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728601, encodeId=2f931e28601f2, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Jan 13 05:15:12 CST 2021, time=2021-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734236, encodeId=c02b1e3423611, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Tue Jun 15 20:15:12 CST 2021, time=2021-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272759, encodeId=2b6712e275979, content=<a href='/topic/show?id=d04f440581e' target=_blank style='color:#2F92EE;'>#大麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44058, encryptionId=d04f440581e, topicName=大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Wed Jul 22 00:15:12 CST 2020, time=2020-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1615532, encodeId=ba301615532e8, content=<a href='/topic/show?id=280196865f7' target=_blank style='color:#2F92EE;'>#镰状细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96865, encryptionId=280196865f7, topicName=镰状细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb4819654385, createdName=1508842480_96220443, createdTime=Wed Jul 22 00:15:12 CST 2020, time=2020-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803611, encodeId=72c08036111e, content=<a href='/topic/show?id=6c7ae057480' target=_blank style='color:#2F92EE;'>#疼痛#</a>是病还是症状?, beContent=null, objectType=article, channel=null, level=null, likeNumber=191, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70574, encryptionId=6c7ae057480, topicName=疼痛)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Tue Jul 21 00:36:49 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036173, encodeId=a23710361e32d, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Mon Jul 20 12:15:12 CST 2020, time=2020-07-20, status=1, ipAttribution=)]
    2021-01-07 醉舞清风2

    慢性疼痛是病

    0

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    2021-01-13 feather89
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    2021-06-15 canlab
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    2020-07-22 kcb069
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  6. [GetPortalCommentsPageByObjectIdResponse(id=914504, encodeId=543591450477, content=慢性疼痛是病, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210107/85c58416bc1443e3b8be867a2e84ebcd/b3508e8c26a9408cbe4bb865d6564b7b.jpg, createdBy=1f135450971, createdName=醉舞清风2, createdTime=Thu Jan 07 21:08:28 CST 2021, time=2021-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728601, encodeId=2f931e28601f2, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Jan 13 05:15:12 CST 2021, time=2021-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734236, encodeId=c02b1e3423611, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Tue Jun 15 20:15:12 CST 2021, time=2021-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272759, encodeId=2b6712e275979, content=<a href='/topic/show?id=d04f440581e' target=_blank style='color:#2F92EE;'>#大麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44058, encryptionId=d04f440581e, topicName=大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Wed Jul 22 00:15:12 CST 2020, time=2020-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1615532, encodeId=ba301615532e8, content=<a href='/topic/show?id=280196865f7' target=_blank style='color:#2F92EE;'>#镰状细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96865, encryptionId=280196865f7, topicName=镰状细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb4819654385, createdName=1508842480_96220443, createdTime=Wed Jul 22 00:15:12 CST 2020, time=2020-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803611, encodeId=72c08036111e, content=<a href='/topic/show?id=6c7ae057480' target=_blank style='color:#2F92EE;'>#疼痛#</a>是病还是症状?, beContent=null, objectType=article, channel=null, level=null, likeNumber=191, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70574, encryptionId=6c7ae057480, topicName=疼痛)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Tue Jul 21 00:36:49 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036173, encodeId=a23710361e32d, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Mon Jul 20 12:15:12 CST 2020, time=2020-07-20, status=1, ipAttribution=)]
    2020-07-21 lovetcm

    #疼痛#是病还是症状?

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=914504, encodeId=543591450477, content=慢性疼痛是病, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210107/85c58416bc1443e3b8be867a2e84ebcd/b3508e8c26a9408cbe4bb865d6564b7b.jpg, createdBy=1f135450971, createdName=醉舞清风2, createdTime=Thu Jan 07 21:08:28 CST 2021, time=2021-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728601, encodeId=2f931e28601f2, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Jan 13 05:15:12 CST 2021, time=2021-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734236, encodeId=c02b1e3423611, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Tue Jun 15 20:15:12 CST 2021, time=2021-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272759, encodeId=2b6712e275979, content=<a href='/topic/show?id=d04f440581e' target=_blank style='color:#2F92EE;'>#大麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44058, encryptionId=d04f440581e, topicName=大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Wed Jul 22 00:15:12 CST 2020, time=2020-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1615532, encodeId=ba301615532e8, content=<a href='/topic/show?id=280196865f7' target=_blank style='color:#2F92EE;'>#镰状细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96865, encryptionId=280196865f7, topicName=镰状细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb4819654385, createdName=1508842480_96220443, createdTime=Wed Jul 22 00:15:12 CST 2020, time=2020-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803611, encodeId=72c08036111e, content=<a href='/topic/show?id=6c7ae057480' target=_blank style='color:#2F92EE;'>#疼痛#</a>是病还是症状?, beContent=null, objectType=article, channel=null, level=null, likeNumber=191, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70574, encryptionId=6c7ae057480, topicName=疼痛)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Tue Jul 21 00:36:49 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036173, encodeId=a23710361e32d, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Mon Jul 20 12:15:12 CST 2020, time=2020-07-20, status=1, ipAttribution=)]
    2020-07-20 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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