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Neurology：生育史影响中年痴呆风险

2021-11-12 自由影像之光 MedSci原创

痴呆风险生育史
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更多雌激素暴露的生殖史事件，如绝经前状态、更长的生殖跨度、更多的儿童、使用HT和HC，与中年妇女更大的GMV相关

最近的研究发现，女性特有的生殖史事件可能是女性阿尔茨海默病（AD）更高患病率的生物学基础。雌激素神经保护作用的临床前证据也表明女性生育能力与AD之间存在联系。

Lisa Mosconi等研究女性生育史雌激素暴露指标与中年阿尔茨海默病（AD）脑MRI生物标志物之间的关系。

该研究利用生殖史数据、神经心理学测试和容积MRI扫描评估了99名52±6岁的认知正常女性和29名52±7岁的男性。使用多元回归来检验生殖史指标、体素灰质体积（GMV）、记忆和整体认知得分之间的相关性，并调整人口统计学和中年健康指标。暴露变量包括更年期状态、初潮年龄、更年期年龄、生育期、子宫切除术状态、儿童和怀孕人数、更年期激素治疗（HT）和激素避孕药（HC）的使用。

与男性相比，所有更年期组AD易感区域的GMV均较低，围绝经期组和绝经后组颞叶皮质的GMV也较绝经前组低。

生殖跨度、儿童和怀孕数量、HT和HC的使用与GMV呈正相关，主要在颞叶皮质、额叶皮质和楔前叶，与年龄、APOE-4状态和中年健康指标无关。尽管生殖史指标与认知测量没有直接关系，但颞区GMV与记忆和整体认知得分呈正相关。

该研究表明更多雌激素暴露的生殖史事件，如绝经前状态、更长的生殖跨度、更多的儿童、使用HT和HC，与中年妇女更大的GMV相关。需要进一步的研究来阐明生殖史影响认知老化和AD风险的性别特异性生物学途径。

原文出处

Association of Reproductive History With Brain MRI Biomarkers of Dementia Risk in Midlife
Eva Schelbaum, Lacey Loughlin, Steven Jett, Cenai Zang, Grace Jang, Niharika Malviya, Hollie Hristov, Silky Pahlajani, Richard Isaacson, Jonathan P Dyke, Hooman Kamel, Roberta Diaz Brinton, Lisa Mosconi
Neurology Nov 2021, 10.1212/WNL.0000000000012941; DOI: 10.1212/WNL.0000000000012941

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  1. [GetPortalCommentsPageByObjectIdResponse(id=2001608, encodeId=977f200160859, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Jul 29 09:58:37 CST 2022, time=2022-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316806, encodeId=164a13168062d, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Sat Nov 13 23:58:37 CST 2021, time=2021-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1069722, encodeId=d4d31069e22df, content=👏👏👏, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c745708488, createdName=ms9000000504403725, createdTime=Fri Nov 12 19:36:23 CST 2021, time=2021-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246352, encodeId=d1711246352c4, content=老年性痴呆，未来还是希望借助神经电生理吧，也许更为有效！, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Fri Nov 12 11:58:37 CST 2021, time=2021-11-12, status=1, ipAttribution=)]
    2022-07-29 yinhl1978

    #Neurol#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2001608, encodeId=977f200160859, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Jul 29 09:58:37 CST 2022, time=2022-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316806, encodeId=164a13168062d, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Sat Nov 13 23:58:37 CST 2021, time=2021-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1069722, encodeId=d4d31069e22df, content=👏👏👏, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c745708488, createdName=ms9000000504403725, createdTime=Fri Nov 12 19:36:23 CST 2021, time=2021-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246352, encodeId=d1711246352c4, content=老年性痴呆，未来还是希望借助神经电生理吧，也许更为有效！, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Fri Nov 12 11:58:37 CST 2021, time=2021-11-12, status=1, ipAttribution=)]
    2021-11-13 pcw106

    #痴呆风险#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2001608, encodeId=977f200160859, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Jul 29 09:58:37 CST 2022, time=2022-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316806, encodeId=164a13168062d, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Sat Nov 13 23:58:37 CST 2021, time=2021-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1069722, encodeId=d4d31069e22df, content=👏👏👏, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c745708488, createdName=ms9000000504403725, createdTime=Fri Nov 12 19:36:23 CST 2021, time=2021-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246352, encodeId=d1711246352c4, content=老年性痴呆，未来还是希望借助神经电生理吧，也许更为有效！, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Fri Nov 12 11:58:37 CST 2021, time=2021-11-12, status=1, ipAttribution=)]
    2021-11-12 ms9000000504403725

    👏👏👏

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2001608, encodeId=977f200160859, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Jul 29 09:58:37 CST 2022, time=2022-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316806, encodeId=164a13168062d, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Sat Nov 13 23:58:37 CST 2021, time=2021-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1069722, encodeId=d4d31069e22df, content=👏👏👏, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c745708488, createdName=ms9000000504403725, createdTime=Fri Nov 12 19:36:23 CST 2021, time=2021-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246352, encodeId=d1711246352c4, content=老年性痴呆，未来还是希望借助神经电生理吧，也许更为有效！, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Fri Nov 12 11:58:37 CST 2021, time=2021-11-12, status=1, ipAttribution=)]
    2021-11-12 neuro.Dr

    老年性痴呆，未来还是希望借助神经电生理吧，也许更为有效！

    0

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