Translational Psychiatry:抑郁症、认知和记忆表型的多变量全基因组关联研究

2022-08-07 MedSci原创 MedSci原创

除了环境因素外,遗传因素在抑郁症和AD中都起着重要的病因作用。

到目前为止,人们对抑郁症、认知和记忆之间的多效遗传变异知之甚少。除了环境因素外,遗传因素在抑郁症和AD中都起着重要的病因作用。根据一项双胞胎研究的荟萃分析,抑郁症的遗传率为31%至42%。

为了阐明上述关系,来自我国山东大学的学者通过在中国人中进行多变量全基因组关联研究和额外的多态性分析,确定这三种表型的潜在多态性单核苷酸多态性(SNPs)、基因和路径,并进一步验证英国生物银行(UKB)中的顶级变异,结果发表在Translational Psychiatry杂志。

参与者是来自青岛双胞胎登记处的139对双卵双胞胎。全基因组高效混合模型分析确定了164个SNPs达到提示性意义(P < 1 × 10-5)。其中,rs3967317(P = 1.21 × 10-8)超过了全基因组的显著性水平(P < 5 × 10-8),并且在多态性分析中也被证明与抑郁症和记忆有关,其次是rs9863698、rs3967316和rs9261381(P = 7.80 × 10-8-5.68 × 10-7),它们与所有三种表型有关。

经过归因,共有457个SNPs达到提示性意义。最重要的SNP chr6:24597173位于KIAA0319基因,该基因在脑组织中有偏向性表达。与代谢、免疫和神经元系统有关的基因和途径在基于基因和途径的富集分析中显示出名义上的意义(P < 0.05)。在验证阶段,上述SNPs中有12个在UKB中达到名义显著性水平(P < 0.05)。其中,3个SNP位于KIAA0319基因,4个SNP被确定为脑组织中显著的表达定量性状位点。

综上,这些发现可能为抑郁症、认知和记忆之间的多态性变异提供证据,并为进一步探索抑郁症与阿尔茨海默病的共同遗传发病机制提供线索。

参考文献:

Multivariate genome-wide association study of depression, cognition, and memory phenotypes and validation analysis identify 12 cross-ethnic variants. Transl Psychiatry 12, 304 (2022). https://doi.org/10.1038/s41398-022-02074-x

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    2023-05-12 bsmagic9140
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    2022-08-09 tastas
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安非他酮在单药治疗和联合治疗中究竟展现了哪些与众不同之处?本文旨在深入探讨这一问题,以期为制定更为精准、有效的抗抑郁治疗方案提供有益参考。

Psychiat Res:耿美玉/李华芳合作揭示抑郁症的肠道菌群紊乱与外周系统紊乱

该研究的发现有助于深入理解MDD的发病机制,为生物标志物的发现研究提供重要依据。

CGP综述与专论|铁死亡:抑郁症治疗的新靶点

本文汇总并讨论了铁死亡参与抑郁症发病机制的可能性,表明铁沉积可能参与了抑郁症的发展进程,铁代谢途径被认为是抗抑郁治疗的潜在靶点,针对抑郁症中的铁死亡治疗将显著提高抗抑郁治疗的效果。

BMJ:抗抑郁竟如此简单?跳舞、散步、慢跑、瑜伽……

运动是治疗抑郁症的有效措施,散步或慢跑、瑜伽和力量训练的效果比其他运动方式更有效,这些运动方式可与药物治疗和心理治疗等结合,作为抑郁症的核心治疗策略。