BMJ:与儿童哮喘相关的空气及家庭因素研究

2020-08-22 MedSci原创 MedSci原创

PM2.5是诱发儿童哮喘和持续性喘息的重要风险因素,其他相关的危险因素包括父母哮喘、父母社会经济地位和孕期吸烟

近日研究人员考察了与儿童哮喘和持续性喘息发作相关的空气污染和家庭相关危险因素。

 

研究为全国病例对照研究,在丹麦开展,参与者为出生于1997年至2014年的丹麦儿童,随访期为1-15岁或哮喘和持续性喘息发作。

研究发现,父母患有哮喘(校正后的危险比为2.29)和怀孕期间母亲吸烟(1.20)儿童的哮喘发病率较高,而教育程度高(0.72)和收入高的父母(0.85),其子女哮喘发病率较低。

暴露于颗粒物质≤2.5 μm (PM2.5)、≤10μm (PM10)和硝酸盐环境与哮喘和持续性喘息风险增加有关,PM2.5、PM10以及二氧化氮污染物浓度每增加5μg/m3的,相应的风险比为1.05、1.04和1.04。

在不同的模型和敏感性分析中,只有PM2.5浓度与哮喘和持续性喘息风险呈正相关。

研究发现,PM2.5是诱发儿童哮喘和持续性喘息的重要风险因素,其他相关的危险因素包括父母哮喘、父母社会经济地位和孕期吸烟。

原始出处:

Gitte J Holstet al. Air pollution and family related determinants of asthma onset and persistent wheezing in children: nationwide case-control study. BMJ,August 19, 2020.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1849083, encodeId=88d91849083a9, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sat Feb 27 05:53:52 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=908505, encodeId=c1a6908505f4, content=社会经济地位,使家庭暴露在环境恶劣、污染、营养不良的情况下的比例也更多些。, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=潛心學習者, createdTime=Wed Dec 16 11:16:41 CST 2020, time=2020-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812781, encodeId=cb70812e8195, content=哮喘发作与环境因素密切相关,已有多项研究证实。<a href='/topic/show?id=052d399242a' target=_blank style='color:#2F92EE;'>#哮喘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39924, encryptionId=052d399242a, topicName=哮喘)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Mon Aug 24 18:12:16 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1295971, encodeId=8eab12959e18a, content=<a href='/topic/show?id=5d41282361d' target=_blank style='color:#2F92EE;'>#儿童哮喘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28236, encryptionId=5d41282361d, topicName=儿童哮喘)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a885259, createdName=yourmama, createdTime=Mon Aug 24 00:53:52 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812490, encodeId=f1c78124902a, content=不错 点赞收藏学习起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLNibQE85E0sLrn9iasdRSCTB5e7ow6EC5ETpKiamzthjhFVNLpj6qKIeianjHUhQl32fPQtkdsiatFfLQ/132, createdBy=4d852205064, createdName=红豆豆豆豆, createdTime=Sun Aug 23 19:52:16 CST 2020, time=2020-08-23, status=1, ipAttribution=)]
    2021-02-27 gaoxiaoe
  2. [GetPortalCommentsPageByObjectIdResponse(id=1849083, encodeId=88d91849083a9, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sat Feb 27 05:53:52 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=908505, encodeId=c1a6908505f4, content=社会经济地位,使家庭暴露在环境恶劣、污染、营养不良的情况下的比例也更多些。, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=潛心學習者, createdTime=Wed Dec 16 11:16:41 CST 2020, time=2020-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812781, encodeId=cb70812e8195, content=哮喘发作与环境因素密切相关,已有多项研究证实。<a href='/topic/show?id=052d399242a' target=_blank style='color:#2F92EE;'>#哮喘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39924, encryptionId=052d399242a, topicName=哮喘)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Mon Aug 24 18:12:16 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1295971, encodeId=8eab12959e18a, content=<a href='/topic/show?id=5d41282361d' target=_blank style='color:#2F92EE;'>#儿童哮喘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28236, encryptionId=5d41282361d, topicName=儿童哮喘)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a885259, createdName=yourmama, createdTime=Mon Aug 24 00:53:52 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812490, encodeId=f1c78124902a, content=不错 点赞收藏学习起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLNibQE85E0sLrn9iasdRSCTB5e7ow6EC5ETpKiamzthjhFVNLpj6qKIeianjHUhQl32fPQtkdsiatFfLQ/132, createdBy=4d852205064, createdName=红豆豆豆豆, createdTime=Sun Aug 23 19:52:16 CST 2020, time=2020-08-23, status=1, ipAttribution=)]
    2020-12-16 潛心學習者

    社会经济地位,使家庭暴露在环境恶劣、污染、营养不良的情况下的比例也更多些。

    0

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    2020-08-24 仁心济世

    哮喘发作与环境因素密切相关,已有多项研究证实。#哮喘#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1849083, encodeId=88d91849083a9, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sat Feb 27 05:53:52 CST 2021, time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=908505, encodeId=c1a6908505f4, content=社会经济地位,使家庭暴露在环境恶劣、污染、营养不良的情况下的比例也更多些。, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=潛心學習者, createdTime=Wed Dec 16 11:16:41 CST 2020, time=2020-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812781, encodeId=cb70812e8195, content=哮喘发作与环境因素密切相关,已有多项研究证实。<a href='/topic/show?id=052d399242a' target=_blank style='color:#2F92EE;'>#哮喘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39924, encryptionId=052d399242a, topicName=哮喘)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Mon Aug 24 18:12:16 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1295971, encodeId=8eab12959e18a, content=<a href='/topic/show?id=5d41282361d' target=_blank style='color:#2F92EE;'>#儿童哮喘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28236, encryptionId=5d41282361d, topicName=儿童哮喘)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a885259, createdName=yourmama, createdTime=Mon Aug 24 00:53:52 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=812490, encodeId=f1c78124902a, content=不错 点赞收藏学习起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLNibQE85E0sLrn9iasdRSCTB5e7ow6EC5ETpKiamzthjhFVNLpj6qKIeianjHUhQl32fPQtkdsiatFfLQ/132, createdBy=4d852205064, createdName=红豆豆豆豆, createdTime=Sun Aug 23 19:52:16 CST 2020, time=2020-08-23, status=1, ipAttribution=)]
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    2020-08-23 红豆豆豆豆

    不错 点赞收藏学习起来

    0

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