Am J Gastroenterol:研究发现憩室病或与结肠粘膜炎症无关

2019-04-15 MedSci MedSci原创

研究认为,无症状或症状性憩室病均与结肠粘膜炎症无关

低度慢性炎症被认为在简单无症状和有症状憩室病中发挥作用,但上述结论缺乏基于人群的研究。近日研究人员在有或无症状的憩室病患者中,考察是否存在结肠炎组织学和血清学的证据。

PopCol研究包含254名结肠镜检查患者,采用逻辑模型和线性回归模型分析憩室病与结肠组织学炎症标志物和血清学C反应蛋白水平的相关性。

病例与对照组在年龄(p=0.92)、性别(p=1.00)、体重指数(p=0.71)、吸烟(p=0.34)、近期接触抗生素(p=0.68)等背景因素相近。病例组报告的腹痛(p=0.04)和腹泻症状(糊状和高频大便)高于对照组(p=0.01和p=0.03),但差异不显著(P>0.05)。病例组平均C反应蛋白水平与对照组相似(1.05 mg vs 0.8)。病例组和对照组相比,盲肠淋巴聚集体的数量有增加的趋势(p=0.07),但在组织学上没有发现憩室病与炎症标志物之间的其他联系。同样,与无症状对照组相比,未发现血清学或粘膜炎症与症状性腹泻或腹痛有关。

研究认为,无症状或症状性憩室病均与结肠粘膜炎症无关。

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    2019-05-30 guoyibin
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    2020-01-29 许安
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    2019-04-17 zutt
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