Br J Cancer:系统性评估和荟萃分析揭示浸润性T细胞标志物在宫颈癌发生中的作用

2020-12-11 xiaozeng MedSci原创

子宫颈癌作为最常见的妇科肿瘤之一,在全球范围内具有较高的发病率和死亡率,在2018年有超过569,000例病例和311,000例死亡病例。尽管目前在高收入人群中的筛查已大大降低了子宫颈癌的发病率,且随

子宫颈癌作为最常见的妇科肿瘤之一,在全球范围内具有较高的发病率和死亡率,在2018年有超过569,000例病例和311,000例死亡病例。尽管目前在高收入人群中的筛查已大大降低了子宫颈癌的发病率,且随着疫苗接种计划的进行将进一步降低该病的发病率,然而,疫苗接种和常规筛查的差异也后导致发病率的巨大差异。

感染致癌性人乳头瘤病毒(HPV)是宫颈癌的必要原因之一。超过90%的HPV感染会在两年内自发清除。宿主的适应性免疫应答有助于确定子宫颈HPV感染是否持续存在并发展为癌前和癌症,而T细胞浸润的系统表征则有助于了解子宫颈癌发生发展的关键步骤。


该研究对正常宫颈、低度病变、高度病变和浸润性癌中的浸润性T细胞进行系统性评估和荟萃分析,包括上皮、基质和总组织以及相关的标记物分析:CD3、CD4、CD8、FoxP3、CD25和CD4:CD8比例。另一项定性评估总结了浸润性T细胞与宫颈疾病的持续性、消退、发生发展以及预后相关性的纵向数据。

流程图

研究人员发现,相比于正常上皮,宫颈病变中的CD3+,CD4+和CD8+细胞更少,而癌症中这些细胞更多。在持续性和癌前病变中,FoxP3和CD25+调节性T细胞的浸润率很高,纵向数据显示,较低的调节性T细胞水平可改善患者的预后。


该研究结果显示,成功的免疫逃逸可以减少HPV感染和癌前上皮细胞中的T细胞浸润反应,而浸润性癌症具有高度的免疫原性,且随着宫颈疾病的发展,调节性T细胞的浸润也会增加。

浸润性T细胞在宫颈癌发生中的概念模型

因此,了解这些因素具有潜在的预后价值,其或可为开发新的治疗方法和临床指南提供一定的指导。


原始出处:

Litwin, T.R., Irvin, S.R., Chornock, R.L. et al. Infiltrating T-cell markers in cervical carcinogenesis: a systematic review and meta-analysis. Br J Cancer (01 December 2020).

 

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    2021-05-04 venlin
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    2021-07-12 1e22b426m70(暂无匿称)

    学习

    0

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    2021-01-06 ms3000000609929442

    学习

    0

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authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/5008534db22c474a844fbd107ff83af2/d3e20fc133b542208ff15e7f2b575329.jpg, createdBy=c7015311102, createdName=Jessie Zhang, createdTime=Fri Dec 11 14:07:59 CST 2020, time=2020-12-11, status=1, ipAttribution=)]
    2020-12-14 1484686em90暂无昵称

    学习

    0

  8. 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createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Sun Dec 13 02:23:47 CST 2020, time=2020-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=907362, encodeId=32d490e36207, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201210/cc4ca81fb34a4ed399c78de99ac479e2/4bce653fb8934d0f98f95c07fd30eaec.jpg, createdBy=5faf2274824, createdName=臭孙慧, createdTime=Sat Dec 12 18:43:19 CST 2020, time=2020-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=907047, encodeId=4e5890e047a2, content=高收入人群中的筛查已大大降低了子宫颈癌的发病率,疫苗接种计划的进行将进一步降低该病的发病率,疫苗接种和常规筛查的差异也后导致发病率的巨大差异。女性的疾病希望更多广大医学从业者给予重视,, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/5008534db22c474a844fbd107ff83af2/d3e20fc133b542208ff15e7f2b575329.jpg, createdBy=c7015311102, createdName=Jessie Zhang, createdTime=Fri Dec 11 14:07:59 CST 2020, time=2020-12-11, status=1, ipAttribution=)]
    2020-12-13 一闲
  9. 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authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/5008534db22c474a844fbd107ff83af2/d3e20fc133b542208ff15e7f2b575329.jpg, createdBy=c7015311102, createdName=Jessie Zhang, createdTime=Fri Dec 11 14:07:59 CST 2020, time=2020-12-11, status=1, ipAttribution=)]
    2020-12-12 臭孙慧

    学习

    0

  10. 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authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/5008534db22c474a844fbd107ff83af2/d3e20fc133b542208ff15e7f2b575329.jpg, createdBy=c7015311102, createdName=Jessie Zhang, createdTime=Fri Dec 11 14:07:59 CST 2020, time=2020-12-11, status=1, ipAttribution=)]
    2020-12-11 Jessie Zhang

    高收入人群中的筛查已大大降低了子宫颈癌的发病率,疫苗接种计划的进行将进一步降低该病的发病率,疫苗接种和常规筛查的差异也后导致发病率的巨大差异。女性的疾病希望更多广大医学从业者给予重视,

    0

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