Diabetes Care:肾功能正常或轻度受损的2型糖尿病患者成纤维细胞生长因子23与死亡率的关系

2019-10-10 xing.T MedSci原创

由此可见,在2型糖尿病且肾功能正常或轻度受损的患者中,FGF23水平与心血管事件和死亡风险增加有关。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员旨在探究肾功能正常或轻度受损的2型糖尿病患者成纤维细胞生长因子23(FGF23)水平是否与不良结局相关。

研究人员分析了310例估计的肾小球过滤率≥60mL/min/1.73m2的2型糖尿病患者FGF23的C末端水平,研究人员通过Cox回归分析了FGF23与全因死亡率和主要不良心血管事件(MACE)之间的相关性。

在5.8年(3.3-6.5)的随访期间,有47例受试者发展为MACE,28例受试者死亡。FGF23与全因死亡率(年龄和性别校正后的风险比为2.78[95%CI为1.76–4.40])和MACE(1.67[1.12-2.49])风险增加相关。在对其他潜在混杂因素进行进一步调整后,结果相似,并且在独立队列中进行重复试验后仍保持一致。

由此可见,在2型糖尿病且肾功能正常或轻度受损的患者中,FGF23水平与心血管事件和死亡风险增加有关。 

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  5. 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  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sat Oct 12 06:03:00 CST 2019, time=2019-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474833, encodeId=faa514e4833d0, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Sat Oct 12 06:03:00 CST 2019, time=2019-10-12, status=1, ipAttribution=)]
    2020-08-07 yese
  7. 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