JCO:你不可不知的秘密:饮食脂肪与肺癌风险相关!

2017-07-31 浮生若梦 来宝网

《临床肿瘤学》杂志7月25日发表的一篇研究表明,总饱和脂肪摄入量高与增加的肺癌风险有关。 美国纳什维尔凡德比特大学医学中心的Jae Jeong Yang教授,及其同事研究了总的、特定类型的饮食脂肪与肺癌风险之间的关系,该团队利用Cox回归模型,对来自美国、欧洲和亚洲的10组前瞻性群组研究进行了汇总分析。 研究人员在经过平均9.4年的随访时间里,在1,445,850名参与者中确认了与肺癌相关的事

临床肿瘤学》杂志7月25日发表的一篇研究表明,总饱和脂肪摄入量高与增加的肺癌风险有关。

美国纳什维尔凡德比特大学医学中心的Jae Jeong Yang教授,及其同事研究了总的、特定类型的饮食脂肪与肺癌风险之间的关系,该团队利用Cox回归模型,对来自美国、欧洲和亚洲的10组前瞻性群组研究进行了汇总分析。

研究人员在经过平均9.4年的随访时间里,在1,445,850名参与者中确认了与肺癌相关的事件18,822例。总饱和脂肪摄入量高与增加的肺癌风险之间存在一定的联系(最高和最低风险比分别为:1.07和1.14,95%的置信区间分别为:1.00-1.15,1.07-1.22;P均<0.001)。相对于曾经/从不吸烟人群,这种联系在当前还在抽烟的人群中更加紧密(风险比1.23,95%置信区间1.13-1.35,P<0.001)。总饱和脂肪摄入量高,患鳞状细胞癌和小细胞癌症风险高于其他的组织学类型癌症(相对风险比分别为1.61和1.40,95%置信区间分别为1.38-1.88、1.17-1.67,P均<0.001)。相反的,多不饱和脂肪摄入量高,则肺癌风险降低(风险比0.92,95%置信区间0.87-0.98,P=0.2)。当饱和脂肪的能量有5%被多不饱和脂肪替代时,小细胞癌和鳞状细胞癌风险会降低16到17个百分点。

研究作者指出,“确认饮食脂肪的摄入(例如,用多不饱和脂肪替代饱和脂肪)可以降低癌症风险,尤其是降低那些吸烟者患鳞状细胞癌和小细胞癌的风险。”

原始出处:

Jae Jeong Yang, Danxia Yu, et al. Dietary Fat Intake and Lung Cancer Risk: A Pooled Analysis. Journal of Clinical Oncology - published online before print July 25, 2017

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    2018-07-10 sjq027
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    2017-09-24 lidong40
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    2017-08-10 1e1263e3m20(暂无匿称)

    脂肪的危害真大,受教了

    0

  5. 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Aug 02 18:52:03 CST 2017, time=2017-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228665, encodeId=dfdc228665f3, content=要注意低脂饮食了学过, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib260FNcic8ThYQJjaU2fLIb1yNqibkbdJs7gVIDr9xJyYeiapArSMjn3W61bPJtpIazSdAxRaFEOKYgfQjX4achN2d/0, createdBy=68472058812, createdName=日月生辉, createdTime=Tue Aug 01 07:19:57 CST 2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228551, encodeId=4233228551fb, content=用多不饱和脂肪替代饱和脂肪可以降低癌症风险,尤其是降低那些吸烟者患鳞状细胞癌和小细胞癌的风险。, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon Jul 31 18:57:31 CST 2017, time=2017-07-31, status=1, ipAttribution=)]
    2017-08-05 yfjms

    学习了

    0

  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon Jul 31 18:57:31 CST 2017, time=2017-07-31, status=1, ipAttribution=)]
    2017-08-02 随梦飞扬

    用多不饱和脂肪替代饱和脂肪可以降低癌症风险,尤其是降低那些吸烟者患鳞状细胞癌和小细胞癌的风险。

    0

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createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Mon Jul 31 20:10:40 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228545, encodeId=4b20228545b3, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Mon Jul 31 19:49:21 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228539, encodeId=b8c7228539fd, content=学习了,谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon Jul 31 18:57:31 CST 2017, time=2017-07-31, status=1, ipAttribution=)]
    2017-08-01 日月生辉

    要注意低脂饮食了学过

    0

  8. 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createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon Jul 31 18:57:31 CST 2017, time=2017-07-31, status=1, ipAttribution=)]
    2017-07-31 随梦飞扬

    用多不饱和脂肪替代饱和脂肪可以降低癌症风险,尤其是降低那些吸烟者患鳞状细胞癌和小细胞癌的风险。

    0

  9. 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Aug 02 18:52:03 CST 2017, time=2017-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228665, encodeId=dfdc228665f3, content=要注意低脂饮食了学过, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib260FNcic8ThYQJjaU2fLIb1yNqibkbdJs7gVIDr9xJyYeiapArSMjn3W61bPJtpIazSdAxRaFEOKYgfQjX4achN2d/0, createdBy=68472058812, createdName=日月生辉, createdTime=Tue Aug 01 07:19:57 CST 2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228551, encodeId=4233228551fb, content=用多不饱和脂肪替代饱和脂肪可以降低癌症风险,尤其是降低那些吸烟者患鳞状细胞癌和小细胞癌的风险。, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Mon Jul 31 20:10:40 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228545, encodeId=4b20228545b3, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Mon Jul 31 19:49:21 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228539, encodeId=b8c7228539fd, content=学习了,谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon Jul 31 18:57:31 CST 2017, time=2017-07-31, status=1, ipAttribution=)]
    2017-07-31 thlabcde

    好东西学习了!

    0

  10. 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createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Mon Jul 31 20:10:40 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228545, encodeId=4b20228545b3, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Mon Jul 31 19:49:21 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228539, encodeId=b8c7228539fd, content=学习了,谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon Jul 31 18:57:31 CST 2017, time=2017-07-31, status=1, ipAttribution=)]
    2017-07-31 惠映实验室

    学习了,谢谢。

    0

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Oncotarget:强磁场科学中心在小细胞肺癌靶向治疗研究中取得进展

近日,强磁场科学中心林文楚研究员课题组在小细胞肺癌靶向治疗研究领域取得重要进展,相关研究成果以“Combination treatment of RAD001 and BEZ235 exhibits synergistic antitumor activity via down-regulation of p-4E-BP1/Mcl-1 in small cell lung cancer”为题,在线

宋勇教授专访:更加精准、更多选择、更多联合!——国家医保目录更新给肺癌患者带来真实世界获益

宋勇 教授南京军区总医院呼吸内科主任,全军呼吸内科专业委员会副主任委员,南京军区呼吸内科委员会主任委员,江苏省医学会呼吸分会副主任委员,中国抗癌协会肺癌专业委员会委员,江苏省医学会呼吸疾病学分会肿瘤及内镜学组副组长。据国家癌症中心数据,2015年中国约有429.2万癌症新发病例,281.4万癌症死亡病例。其中,肺癌以新发病例73.3万例(占整体17.1%)、死亡病例61万例(占整体21.1%)

Oncotarget:双黄升白颗粒剂的治疗骨髓抑制和肺癌的靶点及机制

上海中医药大学附属龙华医院副院长、肿瘤科主任医师徐振晔老师研制的双黄升白颗粒先后二次获上海市科委及国家中医药管理局科研基金的资助,开展了前瞻性、随机、盲法对照临床研究。结果显示:中药双黄升白颗粒升白,防治化疗骨髓抑制的疗效明显优于茜草双酯;与GM-CSF疗效相近,尤其是能有效地治疗Ⅲ°、Ⅳ°重度骨髓抑制。

傻傻分不清!肺癌竟误诊为支气管扩张

患者,男60岁,慢性气管炎20余年,于冬季加重,表现为咳嗽、咳痰、偶有痰中带血,近2~3个月症状加重,经常咯血,一直诊为慢性气管炎,支气管扩张。给予治疗后时好时坏,最后经支气管镜检查为肺癌。哪些因素导致误诊?从中应得到哪些经验教训?患者,男性,60岁,慢性气管炎20余年,于冬季加重,表现为咳嗽,咳痰,偶有痰中带血,近2~3个月症状加重,经常咯血,咯血量较少,只是痰中带血或几口鲜血,一直诊为慢性气管

J Thorac Oncol:呼一口气可鉴别肺癌是否伴有EGFR突变,靠谱吗?

2017年7月11日JTO 在线发表了来自以色列学者Nir Peled研究,利用纳米矩阵感受器对肺可疑结节患者进行呼气分析,鉴别肺良恶性结节、EGFR突变准确性较高,均在80%以上。目前“气体活检”在肺癌良恶性判断、早期发现、组织学类型判断及EGFR是否突变具有不错的前景?