Gastroenterology:乳糜泻与炎症性肠病风险相关性研究

2020-10-19 MedSci原创 MedSci原创

通过系统综述和荟萃分析表明,乳糜泻与炎症性肠病存在一定的联系,其中一种疾病患者患上另一种疾病的风险增加

乳糜泻(CeD)与炎症性肠病(IBD)之间的联系尚存在争议。近日研究人员开展系统回顾和荟萃分析来评估CeD和IBD关联的证据。
 
研究人员收集了截至2019年6月25日,包括MEDLINE、EMBASE、CENTRAL、Web of Science、CINAHL、DARE和SIGLE等数据库数据,以评估IBD患者的CeD风险和CeD患者IBD的风险,并与任何类型的对照组进行了比较。
 
搜索了9791项研究,其中65项研究纳入本次荟萃分析。有中度确定性的证据表明,IBD患者与对照组相比,CeD风险增加(风险比[RR]3.96),而CeD患者与对照组相比,IBD风险增加(RR:9.88)。有低确定性证据表明,与对照组相比,CeD患者的抗酵母菌抗体(IBD的血清学标志物)阳性风险增加(RR:6.22)。有低确定性证据表明,与对照组相比,IBD患者的HLA-DQ2或DQ8无显著异常(RR:1.04)。与对照组相比,IBD患者抗组织谷氨酰胺转胺酶风险增加的证据等级较低(RR:1.52)。与对照组相比,IBD患者抗肌内抗体异常的风险较低(RR 0.70)。
 
通过系统综述和荟萃分析表明,乳糜泻与炎症性肠病存在一定的联系,其中一种疾病患者患上另一种疾病的风险增加。
 
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    2020-11-07 许安
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    2020-10-19 huihui0728

    meta分析进一步证明

    0

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