Circulation:食用椰子油对心血管危险因素的影响

2020-01-15 xing.T MedSci原创

由此可见,食用椰子油会导致LDL-胆固醇明显高于其他植物油。这为选择食用椰子油提供了依据。

椰子油中的饱和脂肪含量很高,因此可能会增加血清胆固醇的浓度,但也有人指出对其他心血管危险因素具有有益作用。因此,近日,心血管领域权威杂志Circulation上发表了一篇研究文章,研究人员对比较椰子油与其他食用油对血脂和其他心血管危险因素影响的临床试验数据进行了系统评价。

研究人员检索了PubMed、SCOPUS、Cochrane Registry和Web of Science数据库,截至2019年6月。研究人员选择了将椰子油与至少持续2周的其他食用油进行比较的试验。两名审稿人根据PRISMA指南(系统评价和荟萃分析的首选报告项目)独立筛选文章,提取数据并评估研究质量。主要结局包括低密度脂蛋白胆固醇(LDL-胆固醇)、高密度脂蛋白胆固醇(HDL-胆固醇)、总胆固醇、甘油三酸酯、体脂、炎症标志和血糖。研究人员使用随机效应荟萃分析汇总数据。

该荟萃分析纳入了16篇文献。所有试验都有血脂数据,8个试验有体重数据,5个试验有体脂百分比数据,4个试验有腰围数据,4个试验有空腹血浆葡萄糖数据,5个试验有C反应蛋白数据。与非热带植物油相比,食用椰子油使LDL-胆固醇水平升高了10.47 mg/dL(95%CI:3.01,17.94; I2=84%,N=16),HDL-胆固醇升高了4.00 mg/dL(95%CI为2.26,5.73; I2=72%,N=16)。在排除非随机试验或质量较差的试验(Jadad得分<3)之后,这些影响仍然很明显。与非热带植物油相比,食用椰子油对血糖、炎症和肥胖的标志物没有显著影响。

由此可见,食用椰子油会导致LDL-胆固醇明显高于其他植物油。这为选择食用椰子油提供了依据。

原始出处:

Nithya Neelakantan,et al.The Effect of Coconut Oil Consumption on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Clinical Trials. Circulation. 2020.https://ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.043052

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