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Sci Transl Med：减肥药liraglutide（利拉鲁肽）的作用机制

2020-03-05 不详 MedSci原创

liraglutideGLP-1R减肥厌食孤束核
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胰高血糖素样肽-1受体(GLP-1R)激动剂liraglutide（利拉鲁肽）已被批准用于治疗肥胖症；该药可减少食物摄入、减轻体重；但关于其影响食物摄入和体重的作用机制尚未完全明确。通过外周给予大鼠liraglutide，部分是通过下丘脑和后脑的GLP-1Rs中枢发挥作用。在本研究中，研究人员进一步发现了后脑GLP-1Rs在调节liraglutide对雄性大鼠的厌食作用中的作用。为了分离GLP-1

胰高血糖素样肽-1受体(GLP-1R)激动剂liraglutide（利拉鲁肽）已被批准用于治疗肥胖症；该药可减少食物摄入、减轻体重；但关于其影响食物摄入和体重的作用机制尚未完全明确。

通过外周给予大鼠liraglutide，部分是通过下丘脑和后脑的GLP-1Rs中枢发挥作用。在本研究中，研究人员进一步发现了后脑GLP-1Rs在调节liraglutide对雄性大鼠的厌食作用中的作用。

为了分离GLP-1Rs在最后区(AP)和孤束核(NTS)中的作用，研究人员研究了liraglutide在NTS AAV-shRNA驱动的Glp1r敲除和AP损伤动物中的作用。敲低NTS GLP-1Rs，可缓解快速予以liraglutide对厌食和体重的减轻作用，但损伤AP无此效应。此外，NTS c-Fos反应可在AP损伤动物中维持。而且，敲低NTS Glp1r还足以减弱长期应用liraglutide（每日服用超过3周）对摄入和体重的抑制作用。

开发改良的肥胖药物疗法需要了解GLP-1R激动剂靶向的细胞表型。通过荧光原位杂交实验发现，NTS GABA能神经元中的Glp1r转录本被药物抑制时可减弱liraglutide对减少食物摄入和减肥的影响。

本研究揭示了NTS GLP-1Rs对liraglutide的厌食效应的作用，并强调了NTS中表达GLP-1R并参与liraglutide信号调节的表型独特的神经元(GABA能神经元)。

原始出处：

Samantha M. Fortin， et al.GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats.Science Translational Medicine  04 Mar 2020：Vol. 12， Issue 533， eaay8071  DOI： 10.1126/scitranslmed.aay8071

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    2020-10-29 lovetcm

    #利拉鲁肽#的#减肥#作用机制已明确

    0

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    2021-01-02 ms3025846204744509

    #Transl#

    0

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    2020-08-23 bsmagic9140

    #TRA#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=895344, encodeId=1de0895344e0, content=<a href='/topic/show?id=401e3230391' target=_blank style='color:#2F92EE;'>#利拉鲁肽#</a>的<a href='/topic/show?id=023031264fd' target=_blank style='color:#2F92EE;'>#减肥#</a>作用机制已明确, beContent=null, objectType=article, channel=null, level=null, likeNumber=183, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32303, encryptionId=401e3230391, topicName=利拉鲁肽), TopicDto(id=31264, encryptionId=023031264fd, topicName=减肥)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Oct 29 10:16:54 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067497, encodeId=e551206e4971c, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sat Jan 02 05:09:00 CST 2021, time=2021-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657299, encodeId=260a165e299eb, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Sun Aug 23 17:09:00 CST 2020, time=2020-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1286175, encodeId=2bed12861e570, content=<a href='/topic/show?id=3be5312e656' target=_blank style='color:#2F92EE;'>#减肥药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31276, encryptionId=3be5312e656, topicName=减肥药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=26a9200, createdName=yangshch, createdTime=Sat Mar 07 03:09:00 CST 2020, time=2020-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610322, encodeId=3ea4161032253, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Mar 07 03:09:00 CST 2020, time=2020-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039201, encodeId=be58103920156, content=机制研究离临床仍然有距离，不过与临床结合思考，仍然有帮助的，不能仅仅是纯临床思维，转化思维同样重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿肿, createdTime=Thu Mar 05 15:09:00 CST 2020, time=2020-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048297, encodeId=5009104829e8d, content=什么时候有懒人用的减肥神药？, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Thu Mar 05 15:09:00 CST 2020, time=2020-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=380093, encodeId=9ec23800938d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02915288922, createdName=ymh8860806_65079110, createdTime=Thu Mar 05 14:29:00 CST 2020, time=2020-03-05, status=1, ipAttribution=)]
    2020-03-07 yangshch

    #减肥药#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=895344, encodeId=1de0895344e0, content=<a href='/topic/show?id=401e3230391' target=_blank style='color:#2F92EE;'>#利拉鲁肽#</a>的<a href='/topic/show?id=023031264fd' target=_blank style='color:#2F92EE;'>#减肥#</a>作用机制已明确, beContent=null, objectType=article, channel=null, level=null, likeNumber=183, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32303, encryptionId=401e3230391, topicName=利拉鲁肽), TopicDto(id=31264, encryptionId=023031264fd, topicName=减肥)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Oct 29 10:16:54 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067497, encodeId=e551206e4971c, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sat Jan 02 05:09:00 CST 2021, time=2021-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657299, encodeId=260a165e299eb, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Sun Aug 23 17:09:00 CST 2020, time=2020-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1286175, encodeId=2bed12861e570, content=<a href='/topic/show?id=3be5312e656' target=_blank style='color:#2F92EE;'>#减肥药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31276, encryptionId=3be5312e656, topicName=减肥药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=26a9200, createdName=yangshch, createdTime=Sat Mar 07 03:09:00 CST 2020, time=2020-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610322, encodeId=3ea4161032253, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Mar 07 03:09:00 CST 2020, time=2020-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039201, encodeId=be58103920156, content=机制研究离临床仍然有距离，不过与临床结合思考，仍然有帮助的，不能仅仅是纯临床思维，转化思维同样重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿肿, createdTime=Thu Mar 05 15:09:00 CST 2020, time=2020-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048297, encodeId=5009104829e8d, content=什么时候有懒人用的减肥神药？, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Thu Mar 05 15:09:00 CST 2020, time=2020-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=380093, encodeId=9ec23800938d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02915288922, createdName=ymh8860806_65079110, createdTime=Thu Mar 05 14:29:00 CST 2020, time=2020-03-05, status=1, ipAttribution=)]
    2020-03-07 ms3994565386320060

    #Med#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=895344, encodeId=1de0895344e0, content=<a href='/topic/show?id=401e3230391' target=_blank style='color:#2F92EE;'>#利拉鲁肽#</a>的<a href='/topic/show?id=023031264fd' target=_blank style='color:#2F92EE;'>#减肥#</a>作用机制已明确, beContent=null, objectType=article, channel=null, level=null, likeNumber=183, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32303, encryptionId=401e3230391, topicName=利拉鲁肽), TopicDto(id=31264, encryptionId=023031264fd, topicName=减肥)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Oct 29 10:16:54 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067497, encodeId=e551206e4971c, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sat Jan 02 05:09:00 CST 2021, time=2021-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657299, encodeId=260a165e299eb, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Sun Aug 23 17:09:00 CST 2020, time=2020-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1286175, encodeId=2bed12861e570, content=<a href='/topic/show?id=3be5312e656' target=_blank style='color:#2F92EE;'>#减肥药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31276, encryptionId=3be5312e656, topicName=减肥药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=26a9200, createdName=yangshch, createdTime=Sat Mar 07 03:09:00 CST 2020, time=2020-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610322, encodeId=3ea4161032253, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Mar 07 03:09:00 CST 2020, time=2020-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039201, encodeId=be58103920156, content=机制研究离临床仍然有距离，不过与临床结合思考，仍然有帮助的，不能仅仅是纯临床思维，转化思维同样重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿肿, createdTime=Thu Mar 05 15:09:00 CST 2020, time=2020-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048297, encodeId=5009104829e8d, content=什么时候有懒人用的减肥神药？, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Thu Mar 05 15:09:00 CST 2020, time=2020-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=380093, encodeId=9ec23800938d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02915288922, createdName=ymh8860806_65079110, createdTime=Thu Mar 05 14:29:00 CST 2020, time=2020-03-05, status=1, ipAttribution=)]
    2020-03-05 肿肿

    机制研究离临床仍然有距离，不过与临床结合思考，仍然有帮助的，不能仅仅是纯临床思维，转化思维同样重要

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=895344, encodeId=1de0895344e0, content=<a href='/topic/show?id=401e3230391' target=_blank style='color:#2F92EE;'>#利拉鲁肽#</a>的<a href='/topic/show?id=023031264fd' target=_blank style='color:#2F92EE;'>#减肥#</a>作用机制已明确, beContent=null, objectType=article, channel=null, level=null, likeNumber=183, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32303, encryptionId=401e3230391, topicName=利拉鲁肽), TopicDto(id=31264, encryptionId=023031264fd, topicName=减肥)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Oct 29 10:16:54 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067497, encodeId=e551206e4971c, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sat Jan 02 05:09:00 CST 2021, time=2021-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657299, encodeId=260a165e299eb, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Sun Aug 23 17:09:00 CST 2020, time=2020-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1286175, encodeId=2bed12861e570, content=<a href='/topic/show?id=3be5312e656' target=_blank style='color:#2F92EE;'>#减肥药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31276, encryptionId=3be5312e656, topicName=减肥药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=26a9200, createdName=yangshch, createdTime=Sat Mar 07 03:09:00 CST 2020, time=2020-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610322, encodeId=3ea4161032253, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Mar 07 03:09:00 CST 2020, time=2020-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039201, encodeId=be58103920156, content=机制研究离临床仍然有距离，不过与临床结合思考，仍然有帮助的，不能仅仅是纯临床思维，转化思维同样重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿肿, createdTime=Thu Mar 05 15:09:00 CST 2020, time=2020-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048297, encodeId=5009104829e8d, content=什么时候有懒人用的减肥神药？, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Thu Mar 05 15:09:00 CST 2020, time=2020-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=380093, encodeId=9ec23800938d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02915288922, createdName=ymh8860806_65079110, createdTime=Thu Mar 05 14:29:00 CST 2020, time=2020-03-05, status=1, ipAttribution=)]
    2020-03-05 CHANGE

    什么时候有懒人用的减肥神药？

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=895344, encodeId=1de0895344e0, content=<a href='/topic/show?id=401e3230391' target=_blank style='color:#2F92EE;'>#利拉鲁肽#</a>的<a href='/topic/show?id=023031264fd' target=_blank style='color:#2F92EE;'>#减肥#</a>作用机制已明确, beContent=null, objectType=article, channel=null, level=null, likeNumber=183, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32303, encryptionId=401e3230391, topicName=利拉鲁肽), TopicDto(id=31264, encryptionId=023031264fd, topicName=减肥)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Oct 29 10:16:54 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067497, encodeId=e551206e4971c, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sat Jan 02 05:09:00 CST 2021, time=2021-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657299, encodeId=260a165e299eb, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Sun Aug 23 17:09:00 CST 2020, time=2020-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1286175, encodeId=2bed12861e570, content=<a href='/topic/show?id=3be5312e656' target=_blank style='color:#2F92EE;'>#减肥药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31276, encryptionId=3be5312e656, topicName=减肥药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=26a9200, createdName=yangshch, createdTime=Sat Mar 07 03:09:00 CST 2020, time=2020-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610322, encodeId=3ea4161032253, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Mar 07 03:09:00 CST 2020, time=2020-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039201, encodeId=be58103920156, content=机制研究离临床仍然有距离，不过与临床结合思考，仍然有帮助的，不能仅仅是纯临床思维，转化思维同样重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿肿, createdTime=Thu Mar 05 15:09:00 CST 2020, time=2020-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048297, encodeId=5009104829e8d, content=什么时候有懒人用的减肥神药？, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Thu Mar 05 15:09:00 CST 2020, time=2020-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=380093, encodeId=9ec23800938d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02915288922, createdName=ymh8860806_65079110, createdTime=Thu Mar 05 14:29:00 CST 2020, time=2020-03-05, status=1, ipAttribution=)]
    2020-03-05 ymh8860806_65079110

    学习了

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