JACC:年龄相关的心功能变化指标与BNP的相关性研究

2019-10-16 不详 MedSci原创

年龄对心脏功能的影响尚未完全阐明,斑点追踪心超可以发现亚临床心功能不全。本研究的目的旨在评估健康的年龄对左室(LV)、右室(RV)和左房(LA)的影响,以及他们与血清B型钠尿肽(BNP)的相关性。本研究对481名体重健康的正常人(平均年龄60±12岁,男性占46%)进行了斑点追踪检测以评估左室整体纵向应变(LVGLS)、右室游离壁应变和左室相应变。BNP水平升高定义为男性BNP >37.82

年龄对心脏功能的影响尚未完全阐明,斑点追踪心超可以发现亚临床心功能不全。本研究的目的旨在评估健康的年龄对左室(LV)、右室(RV)和左房(LA)的影响,以及他们与血清B型钠尿肽(BNP)的相关性。

本研究对481名体重健康的正常人(平均年龄60±12岁,男性占46%)进行了斑点追踪检测以评估左室整体纵向应变(LVGLS)、右室游离壁应变和左室相应变。BNP水平升高定义为男性BNP >37.82 pg/ml和女性>50.86 pg/ml。从50岁开始,在左房储备和管道应变中观察到与年龄相关的心脏功能的最早变化,60岁之后会出现 E/e’峰的增高。LVGLS从70岁后开始降低,而在右室应变、左室射血分数和左室质量指数方面无明显差异。在多元回归分析模型中,年龄是LVGLS降低和左房应变降低的独立预测因子。另外,年龄和左房应变与BNP的升高呈明显相关性,且独立于心室形态和功能。

研究结果显示,左房应变能力的降低是年龄相关最早的心脏功能变化指标,且与BNP升高相关。

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    2020-06-17 hbwxf
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    2019-10-18 huiwelcome
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