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Toxicol Sci：孕妇CrVI暴露引起胎盘Cr积累与氧化应激，且存在着性别二态性

2017-11-27 Emma MedSci原创

六价铬胎盘应激
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六价铬（CrVI）被广泛应用于众多行业，六价铬造成的环境污染在美国和发展中国家都是一个日益严重的问题。

六价铬（CrVI）被广泛应用于众多行业，六价铬造成的环境污染在美国和发展中国家都是一个日益严重的问题。六价铬的环境暴露对两代人的妊娠结局和随后的健康产生不利影响，导致较高的妊娠损失，自然流产和低出生率。

通过职业环境暴露于六价铬的孕妇会增加自然流产、死胎、早产和新生儿死亡的风险，暴露于CrVI的妇女的孩子呼吸障碍，围产期黄疸和出生缺陷增加。由于胎盘功能障碍可能在这样的不良妊娠结局中起作用，因此研究人员推测孕妇的Cr环境暴露导致Cr在人胎盘中累积，可能通过破坏抗氧化机制和诱导细胞凋亡而增加胎盘氧化应激。

使用冷冻的人胎盘样品进行研究表明，Cr在人类胎盘组织中积累，Cr增加积累与氧化应激和凋亡标志物正相关，并改变抗氧化剂水平。有趣的是，Cr积累和氧化应激之间存在着性别二态性，凋亡与抗氧化指标的表达存在相关性。使用人类滋养层细胞BeWo的体外机制研究也证实Cr在改变抗氧化剂基因中的有害作用。

该研究首次提供证据支持人类胎盘中Cr积累与氧化应激加速之间的正相关，以及对男性的性别偏向。

原始出处：
Banu SK, et al. Sexually Dimorphic Impact of Chromium Accumulation on Human Placental Oxidative Stress and Apoptosis. Toxicol Sci. 2017 Oct 23. doi: 10.1093/toxsci/kfx224.

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    2017-12-07 虈亣靌

    不错的.学习了!谢谢分享!

    0

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    2017-12-02 虈亣靌

    不错的.学习了!谢谢分享!

    0

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    2017-11-29 liuyong2981

    #胎盘#

    0

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    2017-11-29 医者仁心

    #应激#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=267540, encodeId=03a526e54081, content=不错的.学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Dec 07 12:27:35 CST 2017, time=2017-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266193, encodeId=fbbe2661933a, content=不错的.学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Dec 02 11:45:27 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1406842, encodeId=a2bd1406842f9, content=<a href='/topic/show?id=2aca8365e2c' target=_blank style='color:#2F92EE;'>#胎盘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83657, encryptionId=2aca8365e2c, topicName=胎盘)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTItxfbnwF4Yku2j227me6wl2EGarBoTicR3tHxrMtib5tnyyEEsgxlHkk8JAS4ZjHsEF7PxhBwh1QwQ/132, createdBy=c8162575557, createdName=liuyong2981, createdTime=Wed Nov 29 05:30:00 CST 2017, time=2017-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445183, encodeId=3d611445183d7, content=<a href='/topic/show?id=61e74928629' target=_blank style='color:#2F92EE;'>#应激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49286, encryptionId=61e74928629, topicName=应激)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed Nov 29 05:30:00 CST 2017, time=2017-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265009, encodeId=5d5226500948, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Tue Nov 28 09:31:59 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264878, encodeId=17bc2648e85e, content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Nov 27 22:43:57 CST 2017, time=2017-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264775, encodeId=a148264e750a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Mon Nov 27 14:53:09 CST 2017, time=2017-11-27, status=1, ipAttribution=)]
    2017-11-28 天涯183

    非常好的文章.学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=267540, encodeId=03a526e54081, content=不错的.学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Dec 07 12:27:35 CST 2017, time=2017-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266193, encodeId=fbbe2661933a, content=不错的.学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Dec 02 11:45:27 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1406842, encodeId=a2bd1406842f9, content=<a href='/topic/show?id=2aca8365e2c' target=_blank style='color:#2F92EE;'>#胎盘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83657, encryptionId=2aca8365e2c, topicName=胎盘)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTItxfbnwF4Yku2j227me6wl2EGarBoTicR3tHxrMtib5tnyyEEsgxlHkk8JAS4ZjHsEF7PxhBwh1QwQ/132, createdBy=c8162575557, createdName=liuyong2981, createdTime=Wed Nov 29 05:30:00 CST 2017, time=2017-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445183, encodeId=3d611445183d7, content=<a href='/topic/show?id=61e74928629' target=_blank style='color:#2F92EE;'>#应激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49286, encryptionId=61e74928629, topicName=应激)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed Nov 29 05:30:00 CST 2017, time=2017-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265009, encodeId=5d5226500948, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Tue Nov 28 09:31:59 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264878, encodeId=17bc2648e85e, content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Nov 27 22:43:57 CST 2017, time=2017-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264775, encodeId=a148264e750a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Mon Nov 27 14:53:09 CST 2017, time=2017-11-27, status=1, ipAttribution=)]
    2017-11-27 1dd8c52fm63(暂无匿称)

    学习学习.了解了解

    0

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    2017-11-27 衣带渐宽

    学习

    0