Neurology:特发性颅内高压的发病率、患病率和结局

2021-01-24 MedSci原创 MedSci原创

IIH的发生率和患病率显著增加,与人群BMI增加相对应,且与贫困程度增加有关。鉴于与IIH相关的合并症、并发症和增加的医疗保健利用率,这对医疗保健专业人员和决策者具有重要意义。

近日,神经病学领域权威杂志Neurology上发表了一篇研究文章,该研究旨在通过常规收集的医疗保健数据来确定特发性颅内高压(IIH)人群的发病率、患病率和医疗保健结局的变化趋势。

在2003年至2017年之间的一项回顾性队列研究中,研究人员在安全匿名信息链接数据库中使用和验证了主要和次要IIH诊断代码,以确定了IIH病例和对照者。研究人员记录了病例组和对照组的体重指数(BMI)、资源剥夺五分位数、脑脊液改道手术和计划外的住院治疗。

研究人员分析了3500万名患者的数据。2017年有1765例IIH病例(女性占85%)。2017年,IIH的患病率和发病率分别为76/100000和7.8/100000/年,比2003年显著增加(相应数字为12/100000和2.3/100000/年)(p<0.001)。IIH患病率与BMI的增加和资源剥夺的增加有关。根据性别和BMI调整后,最少被剥夺的五分位人群与最贫穷的五分位人群发生IIH的比值比为0.65(95%CI为0.55至0.76)。IIH病例中有9%的患者需要CSF分流,而减肥手术则少于0.2%。IIH患者队列的非计划入院率高于对照组(比值比=5.28,p<0.001),并且CSF分流的IIH个体比非分流患者要高(比值比=2.02,p<0.01)。

由此可见,IIH的发生率和患病率显著增加,与人群BMI增加相对应,且与贫困程度增加有关。鉴于与IIH相关的合并症、并发症和增加的医疗保健利用率,这对医疗保健专业人员和决策者具有重要意义。

原始出处:

Latif Miah.et al.Incidence, Prevalence and Healthcare Outcomes in Idiopathic Intracranial Hypertension: A Population Study.Neurology.2021.https://doi.org/10.1212/WNL.0000000000011463

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    2021-04-13 yinhl1978
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