Ann Rheum Dis:华法林与膝关节和髋关节置换风险

2021-05-11 xiangting MedSci原创

与使用DOAC相比,华法林作为一种维生素K拮抗剂,其KR和HR风险更高。

骨关节炎(OA)的预防非常重要,因此需要确定OA的危险因素。华法林是一种维生素K拮抗剂,可能引起胎儿和动物模型的骨骼发育异常。维生素K缺乏与OA有关,但华法林是否会引起OA尚不清楚。

 

这项研究使用英国全科医生电子病历数据库进行了病例对照研究。从刚开具华法林或直接口服抗凝剂(DOACs)的成人房颤患者中确定膝关节或髋关节置换(KR或HR)病例。根据年龄和性别将病例与4个对照进行匹配。使用条件逻辑回归比较了华法林与DOAC和关节置换风险的关系。

共确定了857例KR或HR病例,其中64.6%的患者使用华法林。3428例对照中56.1%使用华法林(平均年龄75岁,女性占47%)。华法林使用者的关节置换风险比使用DOAC高1.59倍(调整OR值为1.59,95%CI为1.31-1.92)。与华法林使用<1年相比,华法林使用时间长与关节置换的风险升高相关。

 

                                            华法林不同使用时间的关节置换HR

由此可见,与使用DOAC相比,华法林作为一种维生素K拮抗剂,其KR和HR风险更高,这说明适当补充维生素K在阻止OA进展中很重要。

 

原始出处:

Priyanka Ballal.Warfarin use and risk of knee and hip replacements. Ann Rheum Dis. May 2021.

 

 

 

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2013626, encodeId=fc012013626b3, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Jul 05 02:34:24 CST 2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1742750, encodeId=62bb1e427507b, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, createdName=yxch48, createdTime=Sun Mar 13 16:34:24 CST 2022, time=2022-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=966210, encodeId=ba9696621069, content=华法林与膝关节置换有相关性, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210515/7df7f6cbd49042d4a6329ae70c7ad7b5/b120f34b2f8846ae821ba21ac1adeab3.jpg, createdBy=24324873661, createdName=1903329706, createdTime=Mon May 17 10:52:52 CST 2021, time=2021-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=964644, encodeId=289f964644e4, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Tue May 11 16:57:34 CST 2021, time=2021-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=964618, encodeId=8e7b96461857, content=骨关节炎(OA)的预防非常重要。, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d8c05498154, createdName=往后余, createdTime=Tue May 11 16:07:51 CST 2021, time=2021-05-11, status=1, ipAttribution=)]
    2022-03-13 yxch48
  3. [GetPortalCommentsPageByObjectIdResponse(id=2013626, encodeId=fc012013626b3, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Jul 05 02:34:24 CST 2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1742750, encodeId=62bb1e427507b, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, createdName=yxch48, createdTime=Sun Mar 13 16:34:24 CST 2022, time=2022-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=966210, encodeId=ba9696621069, content=华法林与膝关节置换有相关性, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210515/7df7f6cbd49042d4a6329ae70c7ad7b5/b120f34b2f8846ae821ba21ac1adeab3.jpg, createdBy=24324873661, createdName=1903329706, createdTime=Mon May 17 10:52:52 CST 2021, time=2021-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=964644, encodeId=289f964644e4, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Tue May 11 16:57:34 CST 2021, time=2021-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=964618, encodeId=8e7b96461857, content=骨关节炎(OA)的预防非常重要。, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d8c05498154, createdName=往后余, createdTime=Tue May 11 16:07:51 CST 2021, time=2021-05-11, status=1, ipAttribution=)]
    2021-05-17 1903329706

    华法林与膝关节置换有相关性

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2013626, encodeId=fc012013626b3, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Jul 05 02:34:24 CST 2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1742750, encodeId=62bb1e427507b, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, createdName=yxch48, createdTime=Sun Mar 13 16:34:24 CST 2022, time=2022-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=966210, encodeId=ba9696621069, content=华法林与膝关节置换有相关性, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210515/7df7f6cbd49042d4a6329ae70c7ad7b5/b120f34b2f8846ae821ba21ac1adeab3.jpg, createdBy=24324873661, createdName=1903329706, createdTime=Mon May 17 10:52:52 CST 2021, time=2021-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=964644, encodeId=289f964644e4, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Tue May 11 16:57:34 CST 2021, time=2021-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=964618, encodeId=8e7b96461857, content=骨关节炎(OA)的预防非常重要。, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d8c05498154, createdName=往后余, createdTime=Tue May 11 16:07:51 CST 2021, time=2021-05-11, status=1, ipAttribution=)]
    2021-05-11 jyzxjiangqin

    好文章!

    0

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    2021-05-11 往后余

    骨关节炎(OA)的预防非常重要。

    0

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