Radiology:3T MR成像在股骨近端微结构显示的价值

2018-04-07 shaosai MedSci原创

本研究旨在验证3T 磁共振(MR)成像是否能通过对股骨近端成像鉴别无骨质疏松患者有无脆性骨折,并将结果发表在Radiology上。

本研究旨在验证3T 磁共振(MR)成像是否能通过对股骨近端成像鉴别无骨质疏松患者有无脆性骨折,并将结果发表在Radiology上。

本研究共纳入了60例绝经后且髋关节骨密度(BMD)T评分≥-2.5女性,所有受试者均行双源X线检查来评价BMD,以及3T MR成像进行髋关节扫描来评价骨微结构。同时计算骨骼世界卫生组织骨折风险评价工具(FRAX)评分。利用Mann-Whitney检验、ROC分析、Spearman相关分析来评价组间差异性、参数分辨力和BMD、微结构和FRAX评分间相关性。

结果为有骨折的患者要比无骨折的患者的股骨颈骨小梁板杆比(中位数,2.41 vs 4.53)、骨小梁厚度(0.556 mm vs 0.630 mm)要低,骨小梁分离程度要高(0.378 mm vs 0.323 mm)以及股骨大转子骨小梁数目较少(0.158 vs 0.192)、骨小梁板杆比较少(6.38 vs 8.09)(P < .05)。股骨颈骨小梁板杆比、宽度和厚度(AUCs, 0.654-0.683)和股骨大转子骨小梁杆分离、数目、连接性、骨小梁板杆比及分离(AUCs, 0.662-0.694)能够鉴别病例组与对照组。股骨颈、关冠军和脊柱BMD在两组间无显着差异,不足以鉴别两组。FRAX有无合并BMD有助于鉴别两组(AUCs, 0.681-0.773)。两因子模型(MR微结构和FRAX评分)能够鉴别两组(AUCs, 0.702-0.806)。在BMD和微结构参数间无线性关系(Spearman ρ, -0.198 to 0.196)。

本研究表明,股骨近端3T MR成像显示微结构能够鉴别有无骨折的BMD T评分超过-2.5的患者,可能提供关于骨骼质量的优于X线的有效信息。

原始出处:


10.1148/radiol.2017170138

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    2018-04-09 hittouch
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    2018-04-08 changjiu

    学习一下谢谢

    0

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    2018-04-07 wqkm

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