J Hepatol:单区域样本评估肝细胞癌中肿瘤免疫微环境的可靠性

2020-05-26 MedSci原创 MedSci原创

肝细胞癌(HCC)患者的肿瘤内异质性经常被报道。因此,单区域肿瘤样本评估肿瘤免疫微环境的可靠性也值得商榷。我们进行了一项前瞻性研究,分析了单区域肿瘤不同区域间肿瘤免疫微环境的相似性。

肝细胞癌(HCC)患者的肿瘤内异质性经常被报道。因此,单区域肿瘤样本评估肿瘤免疫微环境的可靠性也值得商榷。我们进行了一项前瞻性研究,分析了单区域肿瘤不同区域间肿瘤免疫微环境的相似性。

 

对新切除的肿瘤进行了多区域采样。肿瘤免疫微环境通过PD-L1、CD4、CD8、CD8、CD20、FoxP3、DC-LAMP(或LAMP3)、CD68、MPO和三级淋巴组织结构(TLSs)的免疫组化染色来评估肿瘤免疫微环境。PD-L1的表达根据PD-L1染色的肿瘤或基质细胞的百分比进行手动量化。免疫细胞的密度(数量/mm2)和每个样品的TLSs的数量由全切面计数确定。在选定的样本中应用了RNA测序。在每个肿瘤内的肿瘤免疫微环境的相似性通过多变量Mahalanobis距离分析进行评估。

 

从12名患者中收集了13个肿瘤样本。肿瘤的中位直径为9厘米(范围3-16厘米)。每个肿瘤中位数为6个样本(范围3-12)。9个(69.2%)肿瘤在肿瘤的所有区域都表现出PD-L1的均匀表达。免疫组化染色分析的13个肿瘤中,有8个(61.5%)肿瘤在肿瘤内所有区域均表现出较窄的Mahalanobis距离;而RNA测序分析的12个肿瘤中,有8个(66.7%)表现出较窄的Mahalanobis距离。免疫组化和RNA-测序法在评估肿瘤内肿瘤免疫微环境的相似性时,免疫组化和RNA-测序法的吻合率较高(83.3%;12个肿瘤中的10个)。

 

综上所述,该研究结果表明,单一区域的肿瘤样本对大约60-70%的HCC患者的肿瘤免疫微环境的评估可能是可靠的。

 

原始出处:

 

Ying-Chun Shen, Chia-Lang Hs, et al., Reliability of a Single-Region Sample to Evaluate Tumor Immune Microenvironment in Hepatocellular Carcinoma. J Hepatol. 2020 Mar;72(3):489-497. doi: 10.1016/j.jhep.2019.09.032. Epub 2019 Oct 18.

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    2021-03-22 zhzhxiang
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    2021-02-21 xjy02
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