Arthritis Rheumatol:I型干扰素在系统性红斑狼疮患者心血管疾病的发生中起关键作用

2021-04-12 MedSci原创 MedSci原创

中性粒细胞失调和I型干扰素(IFN)轴可导致先天性心血管疾病的发生,是系统性红斑狼疮(SLE)患者死亡的主要原因。近日,研究人员评估了I型IFN受体阻断抗体anifrolumab减少中性粒细胞围捕(N

中性粒细胞失调和I型干扰素(IFN)轴可导致先天性血管疾病的发生,是系统性红斑狼疮(SLE)患者死亡的主要原因。近日,研究人员评估了I型IFN受体阻断抗体anifrolumab减少中性粒细胞围捕(NET)形成和调节心脏代谢疾病标志物的能力,研究结果已发表于Arthritis Rheumatol。

研究纳入参加MUSE试验IIb期的中重度系统性红斑狼疮患者,健康人作为对照组。基线时收集SLE患者(n = 305)和健康对照组(n = 10-20)的血液样本,并在SLE患者接受300 mg阿尼福罗单抗(n = 99)或安慰剂(n = 102)治疗后收集血液样本。确定基线IFN基因特征检测状态,并监测随时间变化。通过多重免疫分析或超敏Simoa测定法测定血清蛋白。评估血浆中的NET复合物、胆固醇排泄能力(CEC)和糖蛋白乙酰化(GlycA)及其他脂质参数。

 

分析结果显示,NET复合物的形成、肿瘤坏死因子(TNF)和白细胞介素-10(IL-10)的水平与I型IFN通路的活性程度相关。与健康对照组相比,系统性红斑狼疮患者的NET复合物和IL-10的表达水平上调(P <0.008)。系统性红斑狼疮患者的心脏代谢疾病标志物CEC和GlycA表达失调(P < 0.001与健康对照组相比)。与基线相比,anifrolumab抑制I型IFN受体可显著降低NET复合物和GlycA的水平,并改善CEC的表达(P < 0.05),而使用安慰剂则没有。与安慰剂相比,anifrolumab的使用降低了TNF和IL-10的水平(P < 0.05)。

综上所述,该研究结果支持I型IFNs在调节导致系统性红斑狼疮血管病变中的关键作用,并表明抑制该途径可以降低系统性红斑狼疮患者的心血管风险。

 

原始出处:

 

Kerry A Casey, et al., Modulation of Cardiometabolic Disease Markers by Type I Interferon Inhibition in Systemic Lupus Erythematosus. Arthritis Rheumatol. 2021 Mar;73(3):459-471. doi: 10.1002/art.41518.  

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【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周分享至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=first smile, createdTime=Mon Apr 12 22:35:35 CST 2021, time=2021-04-12, status=1, ipAttribution=)]
  4. 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【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周分享至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=first smile, createdTime=Mon Apr 12 22:35:35 CST 2021, time=2021-04-12, status=1, ipAttribution=)]
    2021-04-14 zhaojie88
  5. 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  6. 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【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周分享至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=first smile, createdTime=Mon Apr 12 22:35:35 CST 2021, time=2021-04-12, status=1, ipAttribution=)]
    2021-04-14 zhouqu_8
  7. 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【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周分享至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=first smile, createdTime=Mon Apr 12 22:35:35 CST 2021, time=2021-04-12, status=1, ipAttribution=)]
  8. 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【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周分享至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=first smile, createdTime=Mon Apr 12 22:35:35 CST 2021, time=2021-04-12, status=1, ipAttribution=)]
    2021-04-12 gqylhd

    学习了

    0

  9. 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【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周分享至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=first smile, createdTime=Mon Apr 12 22:35:35 CST 2021, time=2021-04-12, status=1, ipAttribution=)]
    2021-04-12 first smile

    三人行,必有我师。 #梅斯医学科研互助群# 欢迎您的加入,添加【梅斯医学科研助手**:medsci_2021】邀您进群! 【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周分享至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!

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