COVID-19可能会引起睾丸损伤,影响男性生殖能力!

2021-01-31 MedSci原创 MedSci原创

新冠肺炎(COVID-19)仍在全球肆虐,据数据显示,全球确诊超1亿308万,累计死亡病例超222.7万例。

新冠肺炎COVID-19)仍在全球肆虐,据数据显示,全球确诊超1亿308万,累计死亡病例超222.7万例。除了咳嗽、发烧、甚至急性呼吸衰竭等呼吸系统症状外,诸多证据显示,新冠病毒可导致全身性疾病,包括消化系统、血管系统以及泌尿系统等等。当然,有研究表明,新冠病毒可以在很大程度上通过细胞因子风暴而破坏男性生殖系统。然而,新冠病毒是否可以直接感染人类睾丸并进入精液尚存争议。

近日,发表在 Reproduction杂志的一项研究表明,COVID-19可能会引起睾丸损伤,男性生殖能力大幅下降。

在这项研究中,研究人员分析了84COVID-19男性患者的精液,每10天对他们精液进行分析发现,COVID-19患者精子细胞的炎症和氧化应激显着增加,且精子浓度,活动性和形状也受到不同程度的影响。

研究人员进一步分析了影响男性生殖的可能机制,主要有直接病毒侵袭生殖细胞并通过性传播病毒;继发性病毒感染引起的炎症反应,严重影响睾丸;病毒感染引起的发烧,干扰正常的生殖生理。值得注意的是,以上机制通常共存,并且在介导损害中具有协同作用。

SARS-CoV-2影响男性生殖系统的潜在途径

此外,男性生殖系统也可能会受到用于治疗病毒感染的药物的影响,其主要原因是诸如糖皮质激素和干扰素的药物具有促性腺激素的作用。病毒与ACE2的结合可引起血管紧张素II的上调,这可能对男性生育力产生不利影响。

总之,初步研究已证实新冠病毒对男性生殖系统有所影响,对于恢复期患者,建议在计划要孩子前应对精子质量进行评估,并咨询医师。当然,睾丸被认为是特定为COVID-19的高风险器官之前,需要进行长期研究。

原始出处

Yu Tian  and Li-quan Zhou.Evaluating the impact of COVID-19 on male reproduction.DOI:https://doi.org/10.1530/REP-20-0523

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    2021-02-02 zhangph
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