Lancet Oncol:透明细胞肾细胞癌中与肥胖悖论相关的转录组特征分析

2020-01-11 AlexYang MedSci原创

肥胖与透明细胞肾细胞癌(RCC)风险的增加相关,但是,矛盾的是肥胖同样与该癌症肿瘤治疗结果的改善相关。因为该矛盾相关性潜在的生物学机制了解很少,最近,有研究人员在肥胖患者和正常体重患者中鉴定了原发肿瘤和瘤旁脂肪组织的转录组差异情况。研究发现,在COMPARZ试验中的453名患者中,375(83%)名患者有可用于分析的基因芯片数据、治疗前BMI测量数据和总生存数据,研究人员排除了119(26%)名超

肥胖与透明细胞肾细胞癌(RCC)风险的增加相关,但是,矛盾的是肥胖同样与该癌症肿瘤治疗结果的改善相关。因为该矛盾相关性潜在的生物学机制了解很少,最近,有研究人员在肥胖患者和正常体重患者中鉴定了原发肿瘤和瘤旁脂肪组织的转录组差异情况。

研究发现,在COMPARZ试验中的453名患者中,375(83%)名患者有可用于分析的基因芯片数据、治疗前BMI测量数据和总生存数据,研究人员排除了119(26%)名超重患者,最后用于群体分析的患者数目为256(68%)名。在TCGA群体中的332名患者中,研究人员评估了肾切除术治疗的152(46%)名晚期(比如阶段III和阶段IV)患者的临床和人口数据;排除了59(39%)名超重患者中,最后群体包括了93(61%)名患者。在第三个起始MSK免疫治疗研究群体中,排除了74(36%)名超重患者后,最终用于总生存分析的群体包括了129(64%)名参与者。研究发现,在调整了病理阶段或者等级后,总生存在肥胖患者中要比正常体重的患者更长(aHR 0·41, 95% CI 0.22-0.75);在COMPARZ临床试验中,调整IMDC风险评分后为(0.68, 0.48-0.96)。在MSK免疫治疗群体中,BMI与死亡率的负相关关系(HR 0.54, 95% CI 0.31-0.95)在调整了IMDC风险评分后并不显著(aHR 0.72, 95% CI 0.40-1.30)。肥胖患者肿瘤表现出了比正常体重患者更高的血管生成评分,而免疫细胞浸润不受BMI影响。研究人员还发现瘤周脂肪组织炎症,尤其是肿瘤附近的瘤周脂肪,相对那些正常体重患者有所增加。

最后,研究人员指出,他们在肿瘤和瘤旁脂肪组织中发现了受BMI影响的肿瘤微环境因素,并可能导致肥胖透明细胞RCC患者比正常体重患者更具有生存优势。透明细胞RCC和瘤周脂肪组织微环境的复杂互作可能具有临床相关性,并且值得进一步的研究。

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    2020-07-03 minlingfeng
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    2020-09-01 howi
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    2020-10-12 mjldent
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    2020-01-11 anti-cancer

    谢谢梅斯分享这么多精彩信息

    0

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