BJOG:怀孕早期开始口服益生菌不会改变女性阴道的微生物组群

2020-08-05 MedSci原创 MedSci原创

本研究旨在确定从怀孕早期开始使用口服益生菌制剂对阴道微生物群的影响。

本研究旨在确定从怀孕早期开始使用口服益生菌制剂对阴道微生物群的影响。

 

采用随机、双盲、安慰剂对照试验设计,在英国的四个产科单位进行,招募了在妊娠9-14周的16岁或以上的女性,将其随机分配到口服含有鼠李糖乳杆菌GR-1和芦荟乳杆菌RC-14的益生菌胶囊,每粒2.5×109菌落形成单位(CFU)或安慰剂,从招募到妊娠结束,每天一次。对可能的混杂因素进行校正分析,比较妊娠18-20周时细菌性阴道病(BV,定义为Nugent评分≥7)的比率。

 

结果,主要分析纳入了78%(238/304)最初同意的参与者(益生菌组123,安慰剂组115)。在这些参与者中,95%(227/238)报告摄入了所需胶囊数量的93%或更多。妊娠18-20周时,BV的发生率在组间没有差异(益生菌组15%(19/123)vs安慰剂组9%(10/115),校正后的OR为1.82,95%置信区间0.64-5.19)。各组之间在益生菌菌株、大肠杆菌、B组链球菌或其他阴道微生物群的女性菌落比例上也没有差异。妊娠9-14周和18-20周时,益生菌组和安慰剂组之间或内部细菌群落的α多样性或组成没有差异。

 

综上所述,该研究结果表明,从怀孕早期开始口服益生菌不会改变阴道微生物群。

 

原始出处:

 

S HusainJ Allotey, et al., Effects of oral probiotic supplements on vaginal microbiota during pregnancy: a randomised, double-blind, placebo-controlled trial with microbiome analysis.BJOG. 2020 Jan;127(2):275-284. doi: 10.1111/1471-0528.15675. 

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    2021-02-19 hittouch
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    2020-08-05 Jessica

    学习了,那体内其他地方的微生物组群有没有改变呢?

    0

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    2020-08-05 神盾医疗局局长Jack

    该研究结果表明,从怀孕早期开始口服益生菌不会改变阴道微生物群。

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1825186, encodeId=05251825186a5, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Mon Apr 26 02:46:39 CST 2021, time=2021-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076599, encodeId=bdb920e6599e3, content=<a href='/topic/show?id=457c5211484' target=_blank style='color:#2F92EE;'>#怀孕早期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52114, encryptionId=457c5211484, topicName=怀孕早期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sun Oct 18 02:46:39 CST 2020, time=2020-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1780370, encodeId=86a11e8037005, content=<a href='/topic/show?id=a5cd3502b5' target=_blank style='color:#2F92EE;'>#BJOG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3502, encryptionId=a5cd3502b5, topicName=BJOG)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Fri Feb 19 02:46:39 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382443, encodeId=d7ba1382443ea, content=<a href='/topic/show?id=49d350e1625' target=_blank style='color:#2F92EE;'>#微生物组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50716, encryptionId=49d350e1625, topicName=微生物组)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Thu Aug 06 15:46:39 CST 2020, time=2020-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394206, encodeId=66b31394206cf, content=<a href='/topic/show?id=1646452e771' target=_blank style='color:#2F92EE;'>#孕早期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45277, encryptionId=1646452e771, topicName=孕早期)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/0EDD6BA8A8C6A0C23E8ABC8BA5331A25/100, createdBy=d37d2500154, createdName=ms5106640509429053, createdTime=Thu Aug 06 15:46:39 CST 2020, time=2020-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=806272, encodeId=c3218062e282, content=学习了,那体内其他地方的微生物组群有没有改变呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Aug 05 10:30:09 CST 2020, time=2020-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=806260, encodeId=c07380626059, content=该研究结果表明,从怀孕早期开始口服益生菌不会改变阴道微生物群。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Wed Aug 05 09:55:20 CST 2020, time=2020-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=806216, encodeId=0cab806216b9, content=学习,方法很棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Wed Aug 05 04:50:52 CST 2020, time=2020-08-05, status=1, ipAttribution=)]
    2020-08-05 1240394fm61暂无昵称

    学习,方法很棒

    0

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