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CLIN CANCER RES：HER-2阳性转移性胃癌曲妥珠单抗原发耐药的生物学标志

2018-03-07 MedSci MedSci原创

胃癌HER-2曲妥珠单抗
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如何选择合适的HER2阳性转移性胃癌患者进行曲妥珠单抗治疗是精准医学的一大挑战。临床前研究发现了几种原发耐药的遗传机制，会导致酪氨酸激酶受体活化而非HER2或下游信号通路活化

如何选择合适的HER2阳性转移性胃癌患者进行曲妥珠单抗治疗是精准医学的一大挑战。临床前研究发现了几种原发耐药的遗传机制，会导致酪氨酸激酶受体活化而非HER2或下游信号通路活化。

作者进行了多中心，前瞻性病例对照研究一系列基因改变（AMNESIA panel）的预测效果，包括EGFR/MET/KRAS/PI3K/PTEN突变和EGFR/MET/KRAS扩增。设定HER2-阳性耐药患者目标突变达到30%，敏感患者突变为0%，每组需要20例患者。研究结果表明，与敏感患者相比，耐药患者AMNESIA panel突变频率更高，HER2 IHC2+的肿瘤突变频率高于HER2 IHC3+的肿瘤。不携带突变的肿瘤患者中位无进展生存和总生存情况更佳。AMNESIA panel和HER2 IHC预测准确性分别为76%和65%。AMNESIA panel联合HER2 IHC预测准确性为84%。

文章最后认为，这些基因突变在预测HER2阳性转移性胃癌患者曲妥珠单抗原发耐药方面具有一定的临床作用，需要进一步对HER2相关肿瘤进行分子分类已寻找更有效的治疗策略。

原始出处：
Filippo Pietrantonio,Giovanni Fuca,et al.Biomarkers of Primary Resistance to Trastuzumab in HER2-Positive Metastatic Gastric Cancer Patients:the AMNESIA Case-Control Study.CLIN CANCER RES.March 2018 doi:10.1158/1078-0432.CCR-17-2781

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    2018-10-27 limedical1985

    #转移性胃癌#

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    2018-11-17 仁心济世

    #曲妥珠#

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    2019-01-10 jiadan198782

    #生物学标志#

    0

  4. 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    2018-03-15 大爰

    学习了谢谢分享!!

    0

  5. 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authenticateStatus=null, createdAvatar=null, createdBy=f59b20519025, createdName=xiaoyeshuang, createdTime=Fri Mar 09 05:32:00 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293893, encodeId=1a0d293893d5, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed Mar 07 17:26:01 CST 2018, time=2018-03-07, status=1, ipAttribution=)]
    2018-03-09 清风拂面

    谢谢分享学习

    0

  6. 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    2018-03-09 1249842em09(暂无昵称)

    #转移性#

    0

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href='/topic/show?id=f08293399f9' target=_blank style='color:#2F92EE;'>#转移性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93399, encryptionId=f08293399f9, topicName=转移性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Fri Mar 09 05:32:00 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1495801, encodeId=5da61495801e0, content=<a href='/topic/show?id=27eb8e1381' target=_blank style='color:#2F92EE;'>#HER-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8713, encryptionId=27eb8e1381, topicName=HER-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6b8b9208832, createdName=zhu_jun9840, createdTime=Fri Mar 09 05:32:00 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1617858, encodeId=95aa161e85890, content=<a href='/topic/show?id=e88f6930185' target=_blank style='color:#2F92EE;'>#生物学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69301, encryptionId=e88f6930185, topicName=生物学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e44019811593, createdName=12498c32m74暂无昵称, createdTime=Fri Mar 09 05:32:00 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623276, encodeId=0c5316232e696, content=<a href='/topic/show?id=62a655263e9' target=_blank style='color:#2F92EE;'>#抗原#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55263, encryptionId=62a655263e9, topicName=抗原)], attachment=null, 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    2018-03-09 zhu_jun9840

    #HER-2#

    0

  8. 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time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1617858, encodeId=95aa161e85890, content=<a href='/topic/show?id=e88f6930185' target=_blank style='color:#2F92EE;'>#生物学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69301, encryptionId=e88f6930185, topicName=生物学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e44019811593, createdName=12498c32m74暂无昵称, createdTime=Fri Mar 09 05:32:00 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623276, encodeId=0c5316232e696, content=<a href='/topic/show?id=62a655263e9' target=_blank style='color:#2F92EE;'>#抗原#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55263, encryptionId=62a655263e9, topicName=抗原)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f59b20519025, createdName=xiaoyeshuang, createdTime=Fri Mar 09 05:32:00 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293893, encodeId=1a0d293893d5, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed Mar 07 17:26:01 CST 2018, time=2018-03-07, status=1, ipAttribution=)]
    2018-03-09 12498c32m74暂无昵称

    #生物学#

    0

  9. 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time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1617858, encodeId=95aa161e85890, content=<a href='/topic/show?id=e88f6930185' target=_blank style='color:#2F92EE;'>#生物学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69301, encryptionId=e88f6930185, topicName=生物学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e44019811593, createdName=12498c32m74暂无昵称, createdTime=Fri Mar 09 05:32:00 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623276, encodeId=0c5316232e696, content=<a href='/topic/show?id=62a655263e9' target=_blank style='color:#2F92EE;'>#抗原#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55263, encryptionId=62a655263e9, topicName=抗原)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f59b20519025, createdName=xiaoyeshuang, createdTime=Fri Mar 09 05:32:00 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293893, encodeId=1a0d293893d5, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed Mar 07 17:26:01 CST 2018, time=2018-03-07, status=1, ipAttribution=)]
    2018-03-09 xiaoyeshuang

    #抗原#

    0

  10. 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    2018-03-07 1ddf0692m34(暂无匿称)

    学习了.涨知识

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