J Endod:聚多巴胺包裹MTA刺激牙髓细胞的成牙本质分化

2018-05-05 lishiting MedSci原创

这篇研究的目的是通过聚多巴胺(PDA)包裹MTA粉剂,检测此种水结合胶结物的水合作用、理化性质和生物学性能,并评估其用在牙和骨组织再生中的可行性。

这篇研究的目的是通过聚多巴胺(PDA)包裹MTA粉剂,检测此种水结合胶结物的水合作用、理化性质和生物学性能,并评估其用在牙和骨组织再生中的可行性。研究将MTA粉剂悬浮于pH 8.5的多巴胺缓冲液中,通过三(羟甲基)氨基甲烷缓冲液在室温下剧烈搅拌12小时。随后,向PDA-coated MTA粉剂中加水混合,在37°C、100%相对湿度下水合反应1天。检测材料的固化时间、机械强度、相成分、表面形态和体外生物学活性,以及它对人牙髓细胞增殖和成牙本质分化的影响。结果显示,PDA包裹MTA后的固化时间明显缩短,但并不影响其机械性能。另外,结果证实,PDA-coated MTA可以上调hDPCs成牙本质分化相关蛋白的表达。碱性磷酸酶活性测试和成牙本质分化相关蛋白检测结果也显示,PDA-coated MTA能够诱导细胞的成牙本质分化。结论:这些结果表明,多巴胺是一种有效的包裹材料,它可以使PDA-MTA底物长效促进人牙髓细胞的生长以及成牙本质分化。这也为未来研发新的以供牙科使用的生物材料提供了重要指引方向。原始出处:Tu MG, Ho CC, et al. Mineral Trioxide Aggr

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    2019-02-21 mnda
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    2018-08-14 jxrzshh
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    2018-05-07 liuxiaona
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    2018-05-07 chengjn
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    2018-05-06 wzb521zf

    一起学习学习

    0

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    2018-05-05 明月清辉

    谢谢分享.学习了

    0

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