Lancet:4价登革热疫苗TAK-003II期临床效果显著

2020-03-18 MedSci原创 MedSci原创

TAK-003疫苗对所有四种登革热血清型都产生了抗体反应,效果不依赖基线血清状况

具有普遍适用性的四价登革热疫苗仍是一个重大挑战,近日研究人员评估了三种不同剂量组合的四价登革热疫苗(tak-003)在48个月内对生活在登革热流行国家儿童的免疫原性和安全性。
 
本次研究为II期临床研究,在多米尼加共和国、巴拿马和菲律宾开展,年龄在2-17岁的健康参与者分别接受2剂量tak-003(第1天和第91天)、1剂量tak-003 (第1天)、1剂量tak-003加增效剂(第1天和第365天)或安慰剂。研究的主要目的是评估在每个方案第48个月各种血清型抗体的几何平均滴度。次要安全终点包括严重不良事件和症状病毒学证实的登革热参与者的比例。
 
1800名儿童参与研究,其中1剂量接种组201人,1剂量接种组398人,1剂量接种加增效剂组1002人,安慰剂组199人,1479名(82%)参与者完成了48个月的研究。在第48个月,与安慰剂组相比,所有TAK-003组的抗体滴度保持升高,与基线血清状态无关。在第48个月,DENV1亚型2剂量组的几何平均滴度为378,1剂量组为421,1剂量加增效剂组为719,安慰剂组为100。各组DENV2亚型几何平均滴度分别为:1052、1319、1200和208。DENV3亚型分别为: 183、201、288(和71。DENV4亚型分别为:152、164、219和46。四价血清阳性率分别为89%、86%、97%和60%。37名(2%)TAK-003组和13名(7%)安慰剂组参与者记录了经病毒学证实的登革热,相对风险为0.35。未报告与疫苗相关的严重不良事件或严重登革热病毒疾病。
 
研究认为,TAK-003疫苗对所有四种登革热血清型都产生了抗体反应,效果不依赖基线血清状况。
 
原始出处:
 

 

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (7)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1830529, encodeId=96fc18305291a, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Jan 05 19:28:57 CST 2021, time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1662503, encodeId=d20116625034b, content=<a href='/topic/show?id=e3d2e160536' target=_blank style='color:#2F92EE;'>#登革热疫苗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71605, encryptionId=e3d2e160536, topicName=登革热疫苗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23bd25409920, createdName=ms2186806800017884, createdTime=Sun Jan 24 09:28:57 CST 2021, time=2021-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1653001, encodeId=3bf816530015c, content=<a href='/topic/show?id=5b011018e07' target=_blank style='color:#2F92EE;'>#I期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10187, encryptionId=5b011018e07, topicName=I期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fc1f24335670, createdName=医生2402, createdTime=Fri Aug 28 02:28:57 CST 2020, time=2020-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1685548, encodeId=c1ba16855488a, content=<a href='/topic/show?id=029e1e09469' target=_blank style='color:#2F92EE;'>#TAK-003#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17094, encryptionId=029e1e09469, topicName=TAK-003)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5f6628226551, createdName=ms6390871039024434, createdTime=Sun Jun 07 05:28:57 CST 2020, time=2020-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1484496, encodeId=7a4014844961b, content=<a href='/topic/show?id=889e2284233' target=_blank style='color:#2F92EE;'>#临床效果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22842, encryptionId=889e2284233, topicName=临床效果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fab7968641, createdName=12498d2fm53(暂无昵称), createdTime=Fri Mar 20 10:28:57 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524789, encodeId=73f71524e89f6, content=<a href='/topic/show?id=4ba395994d' target=_blank style='color:#2F92EE;'>#II期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9599, encryptionId=4ba395994d, topicName=II期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=139811614978, createdName=guihongzh, createdTime=Fri Mar 20 10:28:57 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047015, encodeId=bb0a104e015c1, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Wed Mar 18 22:28:57 CST 2020, time=2020-03-18, status=1, ipAttribution=)]
    2021-01-05 howi
  2. [GetPortalCommentsPageByObjectIdResponse(id=1830529, encodeId=96fc18305291a, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Jan 05 19:28:57 CST 2021, time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1662503, encodeId=d20116625034b, content=<a href='/topic/show?id=e3d2e160536' target=_blank style='color:#2F92EE;'>#登革热疫苗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71605, encryptionId=e3d2e160536, topicName=登革热疫苗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23bd25409920, createdName=ms2186806800017884, createdTime=Sun Jan 24 09:28:57 CST 2021, time=2021-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1653001, encodeId=3bf816530015c, content=<a href='/topic/show?id=5b011018e07' target=_blank style='color:#2F92EE;'>#I期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10187, encryptionId=5b011018e07, topicName=I期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fc1f24335670, createdName=医生2402, createdTime=Fri Aug 28 02:28:57 CST 2020, time=2020-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1685548, encodeId=c1ba16855488a, content=<a href='/topic/show?id=029e1e09469' target=_blank style='color:#2F92EE;'>#TAK-003#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17094, encryptionId=029e1e09469, topicName=TAK-003)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5f6628226551, createdName=ms6390871039024434, createdTime=Sun Jun 07 05:28:57 CST 2020, time=2020-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1484496, encodeId=7a4014844961b, content=<a href='/topic/show?id=889e2284233' target=_blank style='color:#2F92EE;'>#临床效果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22842, encryptionId=889e2284233, topicName=临床效果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fab7968641, createdName=12498d2fm53(暂无昵称), createdTime=Fri Mar 20 10:28:57 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524789, encodeId=73f71524e89f6, content=<a href='/topic/show?id=4ba395994d' target=_blank style='color:#2F92EE;'>#II期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9599, encryptionId=4ba395994d, topicName=II期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=139811614978, createdName=guihongzh, createdTime=Fri Mar 20 10:28:57 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047015, encodeId=bb0a104e015c1, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Wed Mar 18 22:28:57 CST 2020, time=2020-03-18, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1830529, encodeId=96fc18305291a, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Jan 05 19:28:57 CST 2021, time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1662503, encodeId=d20116625034b, content=<a href='/topic/show?id=e3d2e160536' target=_blank style='color:#2F92EE;'>#登革热疫苗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71605, encryptionId=e3d2e160536, topicName=登革热疫苗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23bd25409920, createdName=ms2186806800017884, createdTime=Sun Jan 24 09:28:57 CST 2021, time=2021-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1653001, encodeId=3bf816530015c, content=<a href='/topic/show?id=5b011018e07' target=_blank style='color:#2F92EE;'>#I期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10187, encryptionId=5b011018e07, topicName=I期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fc1f24335670, createdName=医生2402, createdTime=Fri Aug 28 02:28:57 CST 2020, time=2020-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1685548, encodeId=c1ba16855488a, content=<a href='/topic/show?id=029e1e09469' target=_blank style='color:#2F92EE;'>#TAK-003#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17094, encryptionId=029e1e09469, topicName=TAK-003)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5f6628226551, createdName=ms6390871039024434, createdTime=Sun Jun 07 05:28:57 CST 2020, time=2020-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1484496, encodeId=7a4014844961b, content=<a href='/topic/show?id=889e2284233' target=_blank style='color:#2F92EE;'>#临床效果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22842, encryptionId=889e2284233, topicName=临床效果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fab7968641, createdName=12498d2fm53(暂无昵称), createdTime=Fri Mar 20 10:28:57 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524789, encodeId=73f71524e89f6, content=<a href='/topic/show?id=4ba395994d' target=_blank style='color:#2F92EE;'>#II期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9599, encryptionId=4ba395994d, topicName=II期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=139811614978, createdName=guihongzh, createdTime=Fri Mar 20 10:28:57 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047015, encodeId=bb0a104e015c1, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Wed Mar 18 22:28:57 CST 2020, time=2020-03-18, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1830529, encodeId=96fc18305291a, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Jan 05 19:28:57 CST 2021, time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1662503, encodeId=d20116625034b, content=<a href='/topic/show?id=e3d2e160536' target=_blank style='color:#2F92EE;'>#登革热疫苗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71605, encryptionId=e3d2e160536, topicName=登革热疫苗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23bd25409920, createdName=ms2186806800017884, createdTime=Sun Jan 24 09:28:57 CST 2021, time=2021-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1653001, encodeId=3bf816530015c, content=<a href='/topic/show?id=5b011018e07' target=_blank style='color:#2F92EE;'>#I期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10187, encryptionId=5b011018e07, topicName=I期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fc1f24335670, createdName=医生2402, createdTime=Fri Aug 28 02:28:57 CST 2020, time=2020-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1685548, encodeId=c1ba16855488a, content=<a href='/topic/show?id=029e1e09469' target=_blank style='color:#2F92EE;'>#TAK-003#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17094, encryptionId=029e1e09469, topicName=TAK-003)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5f6628226551, createdName=ms6390871039024434, createdTime=Sun Jun 07 05:28:57 CST 2020, time=2020-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1484496, encodeId=7a4014844961b, content=<a href='/topic/show?id=889e2284233' target=_blank style='color:#2F92EE;'>#临床效果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22842, encryptionId=889e2284233, topicName=临床效果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fab7968641, createdName=12498d2fm53(暂无昵称), createdTime=Fri Mar 20 10:28:57 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524789, encodeId=73f71524e89f6, content=<a href='/topic/show?id=4ba395994d' target=_blank style='color:#2F92EE;'>#II期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9599, encryptionId=4ba395994d, topicName=II期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=139811614978, createdName=guihongzh, createdTime=Fri Mar 20 10:28:57 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047015, encodeId=bb0a104e015c1, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Wed Mar 18 22:28:57 CST 2020, time=2020-03-18, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1830529, encodeId=96fc18305291a, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Jan 05 19:28:57 CST 2021, time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1662503, encodeId=d20116625034b, content=<a href='/topic/show?id=e3d2e160536' target=_blank style='color:#2F92EE;'>#登革热疫苗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71605, encryptionId=e3d2e160536, topicName=登革热疫苗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23bd25409920, createdName=ms2186806800017884, createdTime=Sun Jan 24 09:28:57 CST 2021, time=2021-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1653001, encodeId=3bf816530015c, content=<a href='/topic/show?id=5b011018e07' target=_blank style='color:#2F92EE;'>#I期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10187, encryptionId=5b011018e07, topicName=I期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fc1f24335670, createdName=医生2402, createdTime=Fri Aug 28 02:28:57 CST 2020, time=2020-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1685548, encodeId=c1ba16855488a, content=<a href='/topic/show?id=029e1e09469' target=_blank style='color:#2F92EE;'>#TAK-003#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17094, encryptionId=029e1e09469, topicName=TAK-003)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5f6628226551, createdName=ms6390871039024434, createdTime=Sun Jun 07 05:28:57 CST 2020, time=2020-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1484496, encodeId=7a4014844961b, content=<a href='/topic/show?id=889e2284233' target=_blank style='color:#2F92EE;'>#临床效果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22842, encryptionId=889e2284233, topicName=临床效果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fab7968641, createdName=12498d2fm53(暂无昵称), createdTime=Fri Mar 20 10:28:57 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524789, encodeId=73f71524e89f6, content=<a href='/topic/show?id=4ba395994d' target=_blank style='color:#2F92EE;'>#II期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9599, encryptionId=4ba395994d, topicName=II期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=139811614978, createdName=guihongzh, createdTime=Fri Mar 20 10:28:57 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047015, encodeId=bb0a104e015c1, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Wed Mar 18 22:28:57 CST 2020, time=2020-03-18, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1830529, encodeId=96fc18305291a, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Jan 05 19:28:57 CST 2021, time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1662503, encodeId=d20116625034b, content=<a href='/topic/show?id=e3d2e160536' target=_blank style='color:#2F92EE;'>#登革热疫苗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71605, encryptionId=e3d2e160536, topicName=登革热疫苗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23bd25409920, createdName=ms2186806800017884, createdTime=Sun Jan 24 09:28:57 CST 2021, time=2021-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1653001, encodeId=3bf816530015c, content=<a href='/topic/show?id=5b011018e07' target=_blank style='color:#2F92EE;'>#I期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10187, encryptionId=5b011018e07, topicName=I期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fc1f24335670, createdName=医生2402, createdTime=Fri Aug 28 02:28:57 CST 2020, time=2020-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1685548, encodeId=c1ba16855488a, content=<a href='/topic/show?id=029e1e09469' target=_blank style='color:#2F92EE;'>#TAK-003#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17094, encryptionId=029e1e09469, topicName=TAK-003)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5f6628226551, createdName=ms6390871039024434, createdTime=Sun Jun 07 05:28:57 CST 2020, time=2020-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1484496, encodeId=7a4014844961b, content=<a href='/topic/show?id=889e2284233' target=_blank style='color:#2F92EE;'>#临床效果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22842, encryptionId=889e2284233, topicName=临床效果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fab7968641, createdName=12498d2fm53(暂无昵称), createdTime=Fri Mar 20 10:28:57 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524789, encodeId=73f71524e89f6, content=<a href='/topic/show?id=4ba395994d' target=_blank style='color:#2F92EE;'>#II期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9599, encryptionId=4ba395994d, topicName=II期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=139811614978, createdName=guihongzh, createdTime=Fri Mar 20 10:28:57 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047015, encodeId=bb0a104e015c1, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Wed Mar 18 22:28:57 CST 2020, time=2020-03-18, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1830529, encodeId=96fc18305291a, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Jan 05 19:28:57 CST 2021, time=2021-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1662503, encodeId=d20116625034b, content=<a href='/topic/show?id=e3d2e160536' target=_blank style='color:#2F92EE;'>#登革热疫苗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71605, encryptionId=e3d2e160536, topicName=登革热疫苗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23bd25409920, createdName=ms2186806800017884, createdTime=Sun Jan 24 09:28:57 CST 2021, time=2021-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1653001, encodeId=3bf816530015c, content=<a href='/topic/show?id=5b011018e07' target=_blank style='color:#2F92EE;'>#I期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10187, encryptionId=5b011018e07, topicName=I期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fc1f24335670, createdName=医生2402, createdTime=Fri Aug 28 02:28:57 CST 2020, time=2020-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1685548, encodeId=c1ba16855488a, content=<a href='/topic/show?id=029e1e09469' target=_blank style='color:#2F92EE;'>#TAK-003#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17094, encryptionId=029e1e09469, topicName=TAK-003)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5f6628226551, createdName=ms6390871039024434, createdTime=Sun Jun 07 05:28:57 CST 2020, time=2020-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1484496, encodeId=7a4014844961b, content=<a href='/topic/show?id=889e2284233' target=_blank style='color:#2F92EE;'>#临床效果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22842, encryptionId=889e2284233, topicName=临床效果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fab7968641, createdName=12498d2fm53(暂无昵称), createdTime=Fri Mar 20 10:28:57 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524789, encodeId=73f71524e89f6, content=<a href='/topic/show?id=4ba395994d' target=_blank style='color:#2F92EE;'>#II期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9599, encryptionId=4ba395994d, topicName=II期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=139811614978, createdName=guihongzh, createdTime=Fri Mar 20 10:28:57 CST 2020, time=2020-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047015, encodeId=bb0a104e015c1, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Wed Mar 18 22:28:57 CST 2020, time=2020-03-18, status=1, ipAttribution=)]
    2020-03-18 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

相关资讯

特朗普试图斥巨资“掠夺”德国疫苗

特朗普承诺就快有疫苗可用了,但这似乎不太可能。

强生公司宣布与贝斯以色列女执事医疗中心合作,以加快COVID-19疫苗的开发

强生公司今日宣布,已经与贝斯以色列女执事医疗中心(BIDMC)建立了合作关系,以开发针对COVID-19的候选疫苗。双方已开始对多种疫苗进行临床前测试。

新冠肺炎核酸疫苗准备好了吗?一项新技术颠覆研发速度

如果新型冠状病毒可以通过无症状患者传播,那么它的传播将会更难控制,这增加了该种病毒长期进行人际传播的可能性。为此,我们做好准备了吗?

辉瑞也加入到新型冠状病毒COVID-19疫苗的研发阵营

辉瑞公司首席科学官Mikael Dolsten表示,正在与BioNTech进行合作,以利用其基于mRNA的药物开发平台开发COVID-19疫苗。

新型冠状病毒疫苗:会很快来吗?

现在,相信大家都关心这些问题:成功的疫苗研制需要多长时间?新型冠状病毒疫苗的研发之路走到哪儿了?

Nature:姜世勃不宜炒作新冠病毒疫苗,安全性**

在全球范围内,我正在看到努力支持旨在开发针对COVID-19的疫苗和治疗药物:美国和中国的研究小组已经计划在健康的人类志愿者中测试疫苗。